YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|30263837, gi\|...
Organism:	Bacillus anthracis str. Ames
Length:	692 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|30263837, gi|....

Description	E-value	Query Range	Subject Range
gi\|49478403, gi\|... - gi\|49478403\|ref\|YP_037894.1\| DNA topoisomerase I [Bacillus thuringiensis serovar konkukian str. 97-2...	0.0	[1..692]	[1..692]
gi\|42738852, gi\|... - gi\|42782925\|ref\|NP_980172.1\| DNA topoisomerase I [Bacillus cereus ATCC 10987], gi\|42738852\|gb\|AAS427...	0.0	[1..692]	[1..692]
gi\|47552999, gi\|... - gi\|47570334\|ref\|ZP_00240979.1\| DNA topoisomerase I [Bacillus cereus G9241], gi\|47552999\|gb\|EAL11405....	0.0	[1..692]	[1..692]
TOP1_BACHD - DNA topoisomerase 1 OS=Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 /... TOP1_BACHD - DNA topoisomerase 1 OS=Bacillus halodurans GN=topA PE=3 SV=1	0.0	[1..690]	[1..689]
gi\|56910286, gi\|... - gi\|56964043\|ref\|YP_175774.1\| DNA topoisomerase I [Bacillus clausii KSM-K16], gi\|56910286\|dbj\|BAD6481...	0.0	[1..691]	[1..690]
TOP1_BACSU - DNA topoisomerase 1 OS=Bacillus subtilis (strain 168) GN=topA PE=3 SV=1 gi\|221323007 - gi\|221323007\|ref\|ZP_03604301.1\| DNA topoisomerase I [Bacillus subtilis subsp. subtilis str. SMY] TOP1_BACSU - DNA topoisomerase 1 OS=Bacillus subtilis GN=topA PE=3 SV=1 gi\|221313812 - gi\|221313812\|ref\|ZP_03595617.1\| DNA topoisomerase I [Bacillus subtilis subsp. subtilis str. NCIB 361... gi\|221318736 - gi\|221318736\|ref\|ZP_03600030.1\| DNA topoisomerase I [Bacillus subtilis subsp. subtilis str. JH642]	0.0	[1..691]	[1..690]
gi\|52785591, gi\|... - gi\|52785591\|ref\|YP_091420.1\| DNA topoisomerase I [Bacillus licheniformis ATCC 14580], gi\|52348093\|gb...	0.0	[1..691]	[1..690]
gi\|47017710, gi\|... - gi\|47093924\|ref\|ZP_00231663.1\| DNA topoisomerase I [Listeria monocytogenes str. 4b H7858], gi\|470177...	0.0	[1..691]	[1..691]
gi\|68055869, gi\|... - gi\|68055869\|ref\|ZP_00540009.1\| DNA topoisomerase I [Exiguobacterium sibiricum 255-15], gi\|68007592\|g...	0.0	[1..690]	[1..690]

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Predicted Domain #1

Region A:
Residues: [1-578]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDYLVIVES PSKAKTIEKY LGKKYKVVAS MGHVRDLPKS QMGIEVKNNF TPKYITIRGK  60
   61 GPVLKDLKSA AKKAKKVYLA ADPDREGEAI AWHLANTLNV DVESDCRVVF NEITKDAIKE 120
  121 SFKHPRAINM DLVDAQQARR ILDRLVGYNI SPLLWKKVKK GLSAGRVQSV AVRLIIERER 180
  181 EIQSFEPEEF WTIKTEFVKG KDTFEASFYG VDGEKVQLTN ETQVNEIIEQ LKDNAFSVEN 240
  241 VTRKERKRNP ALPFTTSSLQ QEAARKLNMR AKKTMMLAQQ LYEGIDLGKQ GTVGLITYMR 300
  301 TDSTRISETA QTEARTYITE AYGTEYIGAE KKKETKKSNA QDAHEAIRPT SVMRKPEELK 360
  361 SFLSRDQLRL YKLIWERFVA SQMASAIMDT VTARLINNNV QFRASGSVVK FPGFMKVYVE 420
  421 SKDDGAEEKD KMLPPLEVGE TVFSKDLEPK QHFTQPPPRY TEARLVRTLE ELGIGRPSTY 480
  481 VPTLETIQKR GYVGLDNKRF VPTELGEIVI ELILEFFPEI INIEFTANME QSLDEVEEGN 540
  541 ANWVKIVDDF YVGFEPRLEK AEKEMREVEI KDEPAGED

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1eclA
Description:	AMINO TERMINAL 67KDA DOMAIN OF ESCHERICHIA COLI DNA TOPOISOMERASE I (RESIDUES 2-590 OF MATURE PROTEIN) CLONING ARTIFACT ADDS TWO RESIDUES TO THE AMINO-TERMINUS WHICH WERE NOT OBSERVED IN THE EXPERIMENTAL ELECTRON DENSITY (GLY-2, SER-1).
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
DNA topoisomerase activity	9.28485802237784	bayes_pls_golite062009
DNA topoisomerase type I activity	6.20416707013367	bayes_pls_golite062009
isomerase activity	5.61256457337998	bayes_pls_golite062009
nucleic acid binding	3.37048693883188	bayes_pls_golite062009
DNA binding	3.2732257752308	bayes_pls_golite062009
binding	3.07618319631815	bayes_pls_golite062009
catalytic activity	1.50449367975676	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [579-692]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CELCNHPMVF KMGKYGKFMA CSNFPDCRNT KPIVKEIGVT CPKCDKGQII ERRSNKKKRL  60
   61 FYGCGTYPEC DFVSWDKPIG RKCPKCEGML VEKKLKKGVQ VQCISCDYEE EQQM

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.46
Match:	2gaiA
Description:	No description for 2gaiA was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: