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Protein Overview: HIS3_GEOSL

General Information:
Name(s) found: HIS3_GEOSL [Swiss-Prot]
Description(s) found:
Found 5 descriptions.
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  • Phosphoribosyl-AMP cyclohydrolase OS=Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) GN=hisI PE=3 SV=1 [Swiss-Prot]
    • Organism: Geobacter sulfurreducens PCA
    Length: 125 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: histidine biosynthetic process [ISSLink to PubMed article]
    Molecular Function: phosphoribosyl-AMP cyclohydrolase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MITIDFQKMG GLIPAIIQDH ATNEVLMVAF MDEKTLNLTL ESGKTWFFSR SRNKYWMKGE  60
   61 ESGNTQEVVE VLTDCDADAV VIKVKQNGPA ACHTGNRSCF YVRWEDGQWV EHSEPLFDPA 120
  121 EVYKK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..125] PSI-BLAST 48.221849 Crystal structure of Methanobacterium thermoautotrophicum phosphoribosyl-AMP cyclohydrolase HisI

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphoribosyl-AMP cyclohydrolase activity
    		•  4.150200144507 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
    		•  2.23740731288751 bayes_pls_golite062009
  • catalytic activity
    		•  1.39985329737364 bayes_pls_golite062009
  • cyclohydrolase activity
    		•  0.79104127517031 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  0.54834173729282 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle