YRC Public Data Repository - Protein Structure Prediction

Protein:	HIS3_GEOSL
Organism:	Geobacter sulfurreducens PCA
Length:	125 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HIS3_GEOSL.

Description	E-value	Query Range	Subject Range
gi\|241878680, gi... - gi\|241908960\|ref\|ZP_04793518.1\| Phosphoribosyl-AMP cyclohydrolase [Desulfovibrio vulgaris RCH1], gi\|... HIS3_DESVH - Phosphoribosyl-AMP cyclohydrolase OS=Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCI... HIS3_DESVV - Phosphoribosyl-AMP cyclohydrolase OS=Desulfovibrio vulgaris subsp. vulgaris (strain DP4) GN=hisI PE=...	212.0	[0..5]	[124..7]
HIS3_PELPD - Phosphoribosyl-AMP cyclohydrolase OS=Pelobacter propionicus (strain DSM 2379) GN=hisI PE=3 SV=1	211.0	[0..1]	[125..1]
HIS3_GEOUR - Phosphoribosyl-AMP cyclohydrolase OS=Geobacter uraniireducens (strain Rf4) GN=hisI PE=3 SV=1	211.0	[0..1]	[125..1]
HIS3_GEOMG - Phosphoribosyl-AMP cyclohydrolase OS=Geobacter metallireducens (strain GS-15 / ATCC 53774 / DSM 7210...	209.0	[0..1]	[125..1]
HIS31_PSEF5 - Phosphoribosyl-AMP cyclohydrolase 1 OS=Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477) GN=hisI1...	206.0	[0..1]	[123..5]
HIS3_DESAG - Phosphoribosyl-AMP cyclohydrolase OS=Desulfovibrio alaskensis (strain G20) GN=hisI PE=3 SV=1	206.0	[0..5]	[124..11]
gi\|49077240 - gi\|49077240\|gb\|AAT49653.1\| PA5066 [synthetic construct]	206.0	[0..8]	[124..11]
HIS3_PSEPF - Phosphoribosyl-AMP cyclohydrolase OS=Pseudomonas fluorescens (strain Pf0-1) GN=hisI PE=3 SV=1	206.0	[0..1]	[123..5]
HIS3_PSEAE - Phosphoribosyl-AMP cyclohydrolase OS=Pseudomonas aeruginosa GN=hisI PE=3 SV=1 HIS3_PSEA8 - Phosphoribosyl-AMP cyclohydrolase OS=Pseudomonas aeruginosa (strain LESB58) GN=hisI PE=3 SV=1 HIS3_PSEAE - Phosphoribosyl-AMP cyclohydrolase OS=Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101... gi\|84317687, gi\|... - gi\|84317687\|ref\|ZP_00966125.1\| COG0139: Phosphoribosyl-AMP cyclohydrolase [Pseudomonas aeruginosa C3... gi\|84323848, gi\|... - gi\|84323848\|ref\|ZP_00971915.1\| COG0139: Phosphoribosyl-AMP cyclohydrolase [Pseudomonas aeruginosa 21... gi\|107104165 - gi\|107104165\|ref\|ZP_01368083.1\| hypothetical protein PaerPA_01005238 [Pseudomonas aeruginosa PACS2]	206.0	[0..8]	[124..11]
HIS3_PSEAB - Phosphoribosyl-AMP cyclohydrolase OS=Pseudomonas aeruginosa (strain UCBPP-PA14) GN=hisI PE=3 SV=1	206.0	[0..8]	[124..11]

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Predicted Domain #1

Region A:
Residues: [1-125]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MITIDFQKMG GLIPAIIQDH ATNEVLMVAF MDEKTLNLTL ESGKTWFFSR SRNKYWMKGE  60
   61 ESGNTQEVVE VLTDCDADAV VIKVKQNGPA ACHTGNRSCF YVRWEDGQWV EHSEPLFDPA 120
  121 EVYKK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	48.221849
Match:	1zpsA
Description:	Crystal structure of Methanobacterium thermoautotrophicum phosphoribosyl-AMP cyclohydrolase HisI
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphoribosyl-AMP cyclohydrolase activity	4.150200144507	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	2.23740731288751	bayes_pls_golite062009
catalytic activity	1.39985329737364	bayes_pls_golite062009
cyclohydrolase activity	0.79104127517031	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	0.54834173729282	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: