Protein Overview: TF2B_YEAST

General Information:
Name(s) found:	TF2B_YEAST [Swiss-Prot]
Description(s) found:	Transcription initiation factor IIB OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SUA7 PE=1 SV=1 [Swiss-Prot]
Organism:	Saccharomyces cerevisiae S288c
Length:	345 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	NONE FOUND
Molecular Function:	NONE FOUND

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMTRESIDKR AGRRGPNLNI VLTCPECKVY PPKIVERFSE GDVVCALCGL VLSDKLVDTR  60
   61 SEWRTFSNDD HNGDDPSRVG EASNPLLDGN NLSTRIGKGE TTDMRFTKEL NKAQGKNVMD 120
  121 KKDNEVQAAF AKITMLCDAA ELPKIVKDCA KEAYKLCHDE KTLKGKSMES IMAASILIGC 180
  181 RRAEVARTFK EIQSLIHVKT KEFGKTLNIM KNILRGKSED GFLKIDTDNM SGAQNLTYIP 240
  241 RFCSHLGLPM QVTTSAEYTA KKCKEIKEIA GKSPITIAVV SIYLNILLFQ IPITAAKVGQ 300
  301 TLQVTEGTIK SGYKILYEHR DKLVDPQLIA NGVVSLDNLP GVEKK

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..72]	PSI-BLAST	87.751666	Transcription inititiation factor TFIIB, N-terminal domain
2	View Details	[73..232]	PSI-BLAST	279.522879	Transcription factor IIB (TFIIB), core domain
3	View Details	[233..345]	PSI-BLAST	279.522879	Transcription factor IIB (TFIIB), core domain

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
general RNA polymerase II transcription factor activity	5.7605093262441	bayes_pls_golite062009
transcription elongation regulator activity	5.3609198248279	bayes_pls_golite062009
DNA-directed RNA polymerase activity	4.4866621324249	bayes_pls_golite062009
RNA polymerase activity	4.4866621324249	bayes_pls_golite062009
transcription regulator activity	3.36253105801209	bayes_pls_golite062009
nucleic acid binding	2.22594915484417	bayes_pls_golite062009
binding	2.05994835507055	bayes_pls_golite062009
DNA binding	2.01127684131811	bayes_pls_golite062009
positive transcription elongation factor activity	1.80334408907405	bayes_pls_golite062009
RNA polymerase II transcription factor activity	1.57988053581899	bayes_pls_golite062009
nucleotidyltransferase activity	1.44591837933239	bayes_pls_golite062009
DNA primase activity	1.01743034310838	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.71113040164375	bayes_pls_golite062009
protein binding	0.557273506579609	bayes_pls_golite062009
catalytic activity	0.434839928397784	bayes_pls_golite062009
RNA polymerase II transcription elongation factor activity	0.33828634213987	bayes_pls_golite062009

2

Term	Confidence	Notes
general RNA polymerase II transcription factor activity	6.34389570239956	bayes_pls_golite062009
cyclin-dependent protein kinase regulator activity	3.19553060844126	bayes_pls_golite062009
protein kinase regulator activity	2.87088741581791	bayes_pls_golite062009
transcription regulator activity	2.795846725429	bayes_pls_golite062009
binding	2.4204867358489	bayes_pls_golite062009
nucleic acid binding	2.04886889839181	bayes_pls_golite062009
RNA polymerase II transcription factor activity	2.00665312545368	bayes_pls_golite062009
DNA binding	1.94297811210385	bayes_pls_golite062009
transcription elongation regulator activity	1.69439693414478	bayes_pls_golite062009
kinase regulator activity	1.65109787211976	bayes_pls_golite062009
protein binding	1.47106731485576	bayes_pls_golite062009
transcription factor activity	1.21921365719206	bayes_pls_golite062009
transcription factor binding	0.749278791251235	bayes_pls_golite062009
enzyme regulator activity	0.729629809946521	bayes_pls_golite062009
positive transcription elongation factor activity	0.42590121577004	bayes_pls_golite062009
transcription coactivator activity	0.138191616709499	bayes_pls_golite062009
transcription activator activity	0.0696060248241566	bayes_pls_golite062009

3

No functions predicted.

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.86

Source: Reynolds et al. (2008)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle