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Protein Overview: EI2BE_YEAST

General Information:
Name(s) found: EI2BE_YEAST [Swiss-Prot]
Description(s) found:
  • Translation initiation factor eIF-2B subunit epsilon OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GCD6 PE=1 SV=1 [Swiss-Prot]
    • Organism: Saccharomyces cerevisiae S288c
    Length: 712 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAGKKGQKKS GLGNHGKNSD MDVEDRLQAV VLTDSYETRF MPLTAVKPRC LLPLANVPLI  60
   61 EYTLEFLAKA GVHEVFLICS SHANQINDYI ENSKWNLPWS PFKITTIMSP EARCTGDVMR 120
  121 DLDNRGIITG DFILVSGDVL TNIDFSKMLE FHKKMHLQDK DHISTMCLSK ASTYPKTRTI 180
  181 EPAAFVLDKS TSRCIYYQDL PLPSSREKTS IQIDPELLDN VDEFVIRNDL IDCRIDICTS 240
  241 HVPLIFQENF DYQSLRTDFV KGVISSDILG KHIYAYLTDE YAVRVESWQT YDTISQDFLG 300
  301 RWCYPLVLDS NIQDDQTYSY ESRHIYKEKD VVLAQSCKIG KCTAIGSGTK IGEGTKIENS 360
  361 VIGRNCQIGE NIRIKNSFIW DDCIIGNNSI IDHSLIASNA TLGSNVRLND GCIIGFNVKI 420
  421 DDNMDLDRNT KISASPLKNA GSRMYDNESN EQFDQDLDDQ TLAVSIVGDK GVGYIYESEV 480
  481 SDDEDSSTEA CKEINTLSNQ LDELYLSDDS ISSATKKTKK RRTMSVNSIY TDREEIDSEF 540
  541 EDEDFEKEGI ATVERAMENN HDLDTALLEL NTLRMSMNVT YHEVRIATIT ALLRRVYHFI 600
  601 ATQTLGPKDA VVKVFNQWGL LFKRQAFDEE EYIDLMNIIM EKIVEQSFDK PDLILFSALV 660
  661 SLYDNDIIEE DVIYKWWDNV STDPRYDEVK KLTVKWVEWL QNADEESSSE EE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..299] PSI-BLAST 116.917458 N-acetylglucosamine 1-phosphate uridyltransferase GlmU, C-terminal domain; N-acetylglucosamine 1-phosphate uridyltransferase GlmU, N-terminal domain
    2 View Details [300..516] PSI-BLAST 116.917458 N-acetylglucosamine 1-phosphate uridyltransferase GlmU, C-terminal domain; N-acetylglucosamine 1-phosphate uridyltransferase GlmU, N-terminal domain
    3 View Details [517..626] deduced N/A No confident structure predictions are available.
    4 View Details [627..712] Pfam 27.60206 eIF4-gamma/eIF5/eIF2-epsilon No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • uridylyltransferase activity
    		•  3.74072767898515 bayes_pls_golite062009
  • transferase activity, transferring hexosyl groups
    		•  2.70047942699289 bayes_pls_golite062009
  • UTP:glucose-1-phosphate uridylyltransferase activity
    		•  2.65167602524122 bayes_pls_golite062009
  • UTP-monosaccharide-1-phosphate uridylyltransferase activity
    		•  2.46432078102948 bayes_pls_golite062009
  • UDP-glycosyltransferase activity
    		•  2.33861720107822 bayes_pls_golite062009
  • transferase activity
    		•  2.17535315350752 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  2.00651267140641 bayes_pls_golite062009
  • catalytic activity
    		•  1.88676710996045 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.49149681135671 bayes_pls_golite062009
  • acetylgalactosaminyltransferase activity
    		•  1.33788133706753 bayes_pls_golite062009
  • acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity
    		•  1.17181714897181 bayes_pls_golite062009
  • polypeptide N-acetylgalactosaminyltransferase activity
    		•  1.10309252319727 bayes_pls_golite062009
  • binding
    		•  1.09657219604879 bayes_pls_golite062009
  • mannosyltransferase activity
    		•  0.91123217364068 bayes_pls_golite062009
  • transferase activity, transferring glycosyl groups
    		•  0.897978517422275 bayes_pls_golite062009
  • acyltransferase activity
    		•  0.741838450922005 bayes_pls_golite062009
  • transferase activity, transferring acyl groups other than amino-acyl groups
    		•  0.717805296858439 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  0.555398952276587 bayes_pls_golite062009
  • UDP-N-acetylglucosamine diphosphorylase activity
    		•  0.513376694534047 bayes_pls_golite062009
  • O-acyltransferase activity
    		•  0.319932817519902 bayes_pls_golite062009
  • mannose-phosphate guanylyltransferase activity
    		•  0.2363835251362 bayes_pls_golite062009
  • cytidylyltransferase activity
    		•  0.218759888732981 bayes_pls_golite062009
  • guanylyltransferase activity
    		•  0.0539392112504681 bayes_pls_golite062009
    2
    Term Confidence Notes
  • translation initiation factor activity
    		•  9.37171190530754 bayes_pls_golite062009
  • translation regulator activity
    		•  5.35226950142169 bayes_pls_golite062009
  • binding
    		•  3.0667965351474 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.34284977509828 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.76231475025891 bayes_pls_golite062009
  • protein binding
    		•  1.73688475473996 bayes_pls_golite062009
  • RNA cap binding
    		•  1.73309326409609 bayes_pls_golite062009
  • DNA binding
    		•  1.62032607987786 bayes_pls_golite062009
  • transcription factor activity
    		•  0.923253759652909 bayes_pls_golite062009
  • structural molecule activity
    		•  0.908029258648777 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.803700928110921 bayes_pls_golite062009
  • mRNA binding
    		•  0.46864854653143 bayes_pls_golite062009
  • RNA binding
    		•  0.40024158562931 bayes_pls_golite062009
  • transcription activator activity
    		•  0.0232727461674547 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle