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Protein Overview: PMM_YEAST

General Information:
Name(s) found: PMM_YEAST [Swiss-Prot]
Description(s) found:
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  • Phosphomannomutase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SEC53 PE=1 SV=1 [Swiss-Prot]
  • Phosphomannomutase, involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for folding and glycosylation of secretory proteins in the ER lumen [Saccharomyces cerevisiae] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
    • Organism: Saccharomyces cerevisiae S288c
    Length: 254 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSIAEFAYKE KPETLVLFDV DGTLTPARLT VSEEVRKTLA KLRNKCCIGF VGGSDLSKQL  60
   61 EQLGPNVLDE FDYSFSENGL TAYRLGKELA SQSFINWLGE EKYNKLAVFI LRYLSEIDLP 120
  121 KRRGTFLEFR NGMINVSPIG RNASTEERNE FERYDKEHQI RAKFVEALKK EFPDYGLTFS 180
  181 IGGQISFDVF PAGWDKTYCL QHVEKDGFKE IHFFGDKTMV GGNDYEIFVD ERTIGHSVQS 240
  241 PDDTVKILTE LFNL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..254] Pfam 179.236572 Eukaryotic phosphomannomutase No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • hydrolase activity
    		•  1.86932838801412 bayes_pls_golite062009
  • phosphatase activity
    		•  1.65156839204136 bayes_pls_golite062009
  • catalytic activity
    		•  1.55296860681783 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  1.45258865666631 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
    		•  1.33388154652051 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.31348938920819 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.22591357588429 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  1.15184224078831 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of ions
    		•  1.07982919239634 bayes_pls_golite062009
  • di-, tri-valent inorganic cation transmembrane transporter activity
    		•  0.912974008714912 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.911070095136259 bayes_pls_golite062009
  • binding
    		•  0.89911057995199 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.843430522659521 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.764404472034968 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.715824902222533 bayes_pls_golite062009
  • ATPase activity
    		•  0.714770840126679 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.694955044437904 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.693893836676894 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  0.637441292083802 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  0.527631061477265 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  0.454331447449945 bayes_pls_golite062009
  • DNA binding
    		•  0.452491037562571 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  0.287341673798449 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.197599118916494 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.194344891491143 bayes_pls_golite062009
  • cation-transporting ATPase activity
    		•  0.15490458026932 bayes_pls_golite062009
  • kinase activity
    		•  0.126534028294514 bayes_pls_golite062009
  • transporter activity
    		•  0.1049846678839 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.053543166906854 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.041293091790546 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.0313681511675771 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.00294700699983985 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle