Protein Overview: MET10_YEAST

General Information:
Name(s) found:	MET10_YEAST [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	Sulfite reductase [NADPH] flavoprotein component OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MET10 PE=1 SV=2 [Swiss-Prot] Met10p [Saccharomyces cerevisiae] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
Organism:	Saccharomyces cerevisiae S288c
Length:	1035 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	NONE FOUND
Molecular Function:	NONE FOUND

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPVEFATNPF GEAKNATSLP KYGTPVTAIS SVLFNNVDSI FAYKSFSQPD LLHQDLKKWS  60
   61 EKRGNESRGK PFFQELDIRS GAGLAPLGFS HGLKNTTAIV APGFSLPYFI NSLKTVSHDG 120
  121 KFLLNVGALN YDNATGSVTN DYVTALDAAS KLKYGVVTPI SANEVQSVAL LALAIATFSN 180
  181 NSGAINLFDG LNYSKTVLPL VESVPEASIL AKLSKVIAPD AAFDDVLDKF NELTGLRLHN 240
  241 FQYFGAQDAE TVFITYGSLE SELFNSAISG NNSKIGLINV RVPLPFNVAK FVTHVPSTTK 300
  301 QIVVIGQTLD GSSPSFLRSQ VSAALFYHGR TSISVSEYIY QPDFIWSPKA VKSIVSSFIP 360
  361 EFTYNADSSF GEGFIYWASD KSINIDVASK LVKALSLEDG KFVSLRTKFD NLANAGTFQA 420
  421 QFVTSKEQIP VSNIDSTKLS VVEDVSLLKH LDVAATVAEQ GSIALVSQKA VKDLDLNSVE 480
  481 SYVKNLGIPE SFLISIAKKN IKLFIIDGET TNDESKLSLF IQAVFWKLAF GLDVAECTNR 540
  541 IWKSIDSGAD ISAASISEFL TGAFKNFLSE VPLALYTKFS EINIEKKEDE EEPAALPIFV 600
  601 NETSFLPNNS TIEEIPLPET SEISDIAKKL SFKEAYEVEN KLRPDLPVKN FVVKVKENRR 660
  661 VTPADYDRYI FHIEFDISGT GMTYDIGEAL GIHARNNESL VKEFLTFYGL NESDVVLVPN 720
  721 KDNHHLLETR TVLQAFVENL DIFGKPPKRF YESLIPYASN EEEKKKLEDL VTPAGAVDLK 780
  781 RFQDVEYYTY ADIFELFPSV RPSLEELVTI IEPLKRREYS IASSQKVHPN EVHLLIVVVD 840
  841 WVDNKGRKRY GQASKYISDL AVGSELVVSV KPSVMKLPPS PKQPVIMSGL GTGLAPFKAI 900
  901 VEEKLWQKQQ GYEIGEVFLY LGSRHKREEY LYGELWEAYK DAGIITHIGA AFSRDQPQKI 960
  961 YIQDRIKENL DELKTAMIDN KGSFYLCGPT WPVPDITQAL QDILAKDAEE RGIKVDLDAA1020
 1021 IEELKEASRY ILEVY

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..373]	PSI-BLAST	231.9897	Pyruvate-ferredoxin oxidoreductase, PFOR, domain I; Pyruvate-ferredoxin oxidoreductase, PFOR, domains VI; Pyruvate-ferredoxin oxidoreductase, PFOR, domain II; Pyruvate-ferredoxin oxidoreductase, PFOR, domain III; Pyruvate-ferredoxin oxidoreductase, PFOR, domain V
2	View Details	[374..643]	PSI-BLAST	231.9897	Pyruvate-ferredoxin oxidoreductase, PFOR, domain I; Pyruvate-ferredoxin oxidoreductase, PFOR, domains VI; Pyruvate-ferredoxin oxidoreductase, PFOR, domain II; Pyruvate-ferredoxin oxidoreductase, PFOR, domain III; Pyruvate-ferredoxin oxidoreductase, PFOR, domain V
3	View Details	[644..694] [816..839] [852..873]	PSI-BLAST	618.54902	NADPH-cytochrome p450 reductase; NADPH-cytochrome p450 reductase, N-terminal domain
4	View Details	[695..815] [840..851] [874..1035]	PSI-BLAST	618.54902	NADPH-cytochrome p450 reductase; NADPH-cytochrome p450 reductase, N-terminal domain

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
oxidoreductase activity, acting on sulfur group of donors	2.53979678006253	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	1.31432587516415	bayes_pls_golite062009
pyruvate dehydrogenase activity	1.05771099058484	bayes_pls_golite062009
pyruvate dehydrogenase (acetyl-transferring) activity	0.91689889002022	bayes_pls_golite062009
catalytic activity	0.488483980994331	bayes_pls_golite062009
binding	0.284953915352797	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH	0.240775137189639	bayes_pls_golite062009
acetolactate synthase activity	0.201869061877972	bayes_pls_golite062009

2

Term	Confidence	Notes
sulfite reductase (NADPH) activity	8.084406223553	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor	4.30314846685644	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	4.06091555929351	bayes_pls_golite062009
catalytic activity	1.45374095556065	bayes_pls_golite062009
transferase activity, transferring alkyl or aryl (other than methyl) groups	1.198269073975	bayes_pls_golite062009
oxidoreductase activity	0.812246071526761	bayes_pls_golite062009
transferase activity	0.708491789248912	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH	0.637241226597849	bayes_pls_golite062009
binding	0.568113451649995	bayes_pls_golite062009

3

No functions predicted.

4

No functions predicted.

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.94

Source: Reynolds et al. (2008)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle