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Protein Overview: RGD2_YEAST

General Information:
Name(s) found: RGD2_YEAST [Swiss-Prot]
Description(s) found:
Found 2 descriptions.
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  • Rho-GTPase-activating protein RGD2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RGD2 PE=1 SV=1 [Swiss-Prot]
    • Organism: Saccharomyces cerevisiae S288c
    Length: 714 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSFCDYFWS EDLVSGLDVL FDRLYHGCEQ CDLFIQLFAS RMQFEVSHGR QLFGIEAGMD  60
   61 NLKAVQEDED EGVTVSRALR GILQEMSQEG THHLTIASNI ESLVLQPFSK WCIEHRERIQ 120
  121 YSEKTLLTNV NNFRKSKKYV GKLEKEYFNK CRQLEEFKRT HFNEDELANA MKSLKIQNKY 180
  181 EEDVAREKDH RFFNRIAGID FDYKTMKETL QLLLTKLPKT DYKLPLISYS LSNTNNGGEI 240
  241 TKFLLDHMSL KDIDQAETFG QDLLNLGFLK YCNGVGNTFV NSKKFQYQWK NTAYMFANVP 300
  301 MPGSEEPTTG ESLISRFNNW DGSSAKEIIQ SKIGNDQGAA KIQAPHISDN ERTLFRMMDA 360
  361 LAASDKKYYQ ECFKMDALRC SVEELLIDHL SFMEKCESDR LNAIKKATLD FCSTLGNKIS 420
  421 SLRLCIDKML TLENDIDPTA DLLQLLVKYK TGSFKPQAIV YNNYYNPGSF QNFGVDLETR 480
  481 CRLDKKVVPL IISSIFSYMD KIYPDLPNDK VRTSIWTDSV KLSLTHQLRN LLNKQQFHNE 540
  541 GEIFDILSTS KLEPSTIASV VKIYLLELPD PLIPNDVSDI LRVLYLDYPP LVETALQNST 600
  601 SSPENQQDDD NEEGFDTKRI RGLYTTLSSL SKPHIATLDA ITTHFYRLIK ILKMGENGNE 660
  661 VADEFTVSIS QEFANCIIQS KITDDNEIGF KIFYDLLTHK KQIFHELKRQ NSKN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..225] ORFEUS 9.07 Apolipoprotein A-I
    2 View Details [226..299] Pfam 12.180456 Domain found in Dishevelled, Egl-10, and Pleckstrin No confident structure predictions are available.
    3 View Details [300..366] deduced N/A No confident structure predictions are available.
    4 View Details [367..569] PSI-BLAST 38.0 p50 RhoGAP domain
    5 View Details [570..714] PSI-BLAST 38.0 p50 RhoGAP domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • cytoskeletal protein binding
    		•  3.124619761789 bayes_pls_golite062009
  • binding
    		•  2.22529267810903 bayes_pls_golite062009
  • protein binding
    		•  1.87308005875135 bayes_pls_golite062009
  • identical protein binding
    		•  0.909409198394921 bayes_pls_golite062009
  • enzyme binding
    		•  0.58709209959999 bayes_pls_golite062009
  • GTPase binding
    		•  0.50066793947946 bayes_pls_golite062009
  • GTPase regulator activity
    		•  0.459881864914566 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.456472132383968 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.180886944097381 bayes_pls_golite062009
  • small GTPase binding
    		•  0.0531578648468707 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • GTPase regulator activity
    		•  5.23789256375467 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  5.21562004568462 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  4.91645234075732 bayes_pls_golite062009
  • GTPase activator activity
    		•  4.81440293338491 bayes_pls_golite062009
  • Ras GTPase activator activity
    		•  4.76400460221691 bayes_pls_golite062009
  • Rho GTPase activator activity
    		•  4.58620967349979 bayes_pls_golite062009
  • enzyme regulator activity
    		•  4.5322075775333 bayes_pls_golite062009
  • Rac GTPase activator activity
    		•  4.48279904625182 bayes_pls_golite062009
  • enzyme activator activity
    		•  4.29367232260052 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  3.68681762274025 bayes_pls_golite062009
  • actin binding
    		•  3.68337819140185 bayes_pls_golite062009
  • actin filament binding
    		•  2.37781909937968 bayes_pls_golite062009
  • microfilament motor activity
    		•  2.15518436158221 bayes_pls_golite062009
  • binding
    		•  1.62780792681766 bayes_pls_golite062009
  • protein binding
    		•  1.21496582666968 bayes_pls_golite062009
  • Rho guanyl-nucleotide exchange factor activity
    		•  0.967362611034944 bayes_pls_golite062009
  • enzyme binding
    		•  0.56024350956935 bayes_pls_golite062009
  • GTPase binding
    		•  0.54882559587114 bayes_pls_golite062009
  • small GTPase binding
    		•  0.36738560339155 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle