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Protein Overview: TYDP1_YEAST

General Information:
Name(s) found: TYDP1_YEAST [Swiss-Prot]
Description(s) found:
Found 2 descriptions.
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  • Tyrosyl-DNA phosphodiesterase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TDP1 PE=1 SV=1 [Swiss-Prot]
    • Organism: Saccharomyces cerevisiae S288c
    Length: 544 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRETNFNGT KRKRSDVAEK VAQRWKSVRY SAEMENMAPV NSNNDSDDCV IVSESKIIDL  60
   61 TNQEQDLSER IETNDTAKGA VFKLMKSDFY EREDFMGEVE DMITLKDIFG TETLKRSILF 120
  121 SFQYELDFLL RQFHQNVENI TIVGQKGTIM PIEARAMDAT LAVILKKVKL IEITMPPFAS 180
  181 HHTKLIINFY DNGECKIFLP SNNFTSMETN LPQQVCWCSP LLKIGKEGLP VPFKRSLIEY 240
  241 LNSYHLKDID ELITKSVEEV NFAPLSELEF VYSTPSKFQS SGLLSFYNKL EKLSAGTSAS 300
  301 DTAKHYLCQT SSIGTSLSRA RDENLWTHLM IPLFTGIMSP PAKDTAGRKK AEILPTNSLI 360
  361 NEYSQRKIKP YIIFPTEQEF VTSPLKWSSS GWFHFQYLQK KSYYEMLRNK FKVFYKQDPA 420
  421 MVTRRRGTTP AHSKFYMHCA TNSAGPCDAS QVFKELEWCL YTSANLSQTA WGTVSRKPRN 480
  481 YEAGVLYHSR RLANTRKVTC RTFTRDRRGC AGNPTHVAVP FTLPVIPYDL AEDECFCLAR 540
  541 HEND

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..222] PSI-BLAST 289.9897 Tyrosyl-DNA phosphodiesterase TDP1
    2 View Details [223..268] PSI-BLAST 289.9897 Tyrosyl-DNA phosphodiesterase TDP1
    3 View Details [269..287]
    [461..486]    		 PSI-BLAST 289.9897 Tyrosyl-DNA phosphodiesterase TDP1
    4 View Details [288..460]
    [487..544]    		 PSI-BLAST 289.9897 Tyrosyl-DNA phosphodiesterase TDP1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • 3'-tyrosyl-DNA phosphodiesterase activity
    		•  1.46693175347055 bayes_pls_golite062009
  • tyrosyl-DNA phosphodiesterase activity
    		•  1.46693175347055 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.41591686174898 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  1.29668490323599 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  1.29429720882252 bayes_pls_golite062009
  • catalytic activity
    		•  1.29236214516383 bayes_pls_golite062009
  • binding
    		•  1.26667168593698 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.926017334343152 bayes_pls_golite062009
  • DNA binding
    		•  0.840595330626189 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.235198647671849 bayes_pls_golite062009
  • protein binding
    		•  0.162885453822356 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle