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View Structure Prediction Details

Protein: TYDP1_YEAST
Organism: Saccharomyces cerevisiae S288c
Length: 544 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TYDP1_YEAST.

Description E-value Query
Range
Subject
Range
TDP1 - Tyrosyl-DNA Phosphodiesterase I, hydrolyzes 3' and 5'-phosphotyrosyl bonds, involved in the repair o...
TYDP1_YEAST - Tyrosyl-DNA phosphodiesterase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TDP1 PE=...
0.0 [1..544] [1..544]
TDP1 - tyrosyl-DNA phosphodiesterase 1
0.0 [18..536] [105..589]
gkt-PA - The gene glaikit is referred to in FlyBase by the symbol Dmel\gkt (CG8825, FBgn0260817). It is a pro...
gi|220946228 - gi|220946228|gb|ACL85657.1| gkt-PA [synthetic construct]
0.0 [71..538] [135..576]
gi|17381098 - gi|17381098|gb|AAL36361.1| unknown protein [Arabidopsis thaliana]
0.0 [75..539] [137..591]
TYDP1_SCHPO - Probable tyrosyl-DNA phosphodiesterase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPC...
SPCP31B10.05 - tyrosyl-DNA phosphodiesterase
0.0 [60..533] [2..514]
CE19434 - status:Partially_confirmed UniProt:Q9TXV7 protein_id:AAC68960.1
0.0 [74..542] [28..439]
gi|18044048 - gi|18044048|gb|AAH19804.1| Tdp1 protein [Mus musculus]
0.0 [185..536] [1..324]

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Predicted Domain #1
Region A:
Residues: [1-222]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRETNFNGT KRKRSDVAEK VAQRWKSVRY SAEMENMAPV NSNNDSDDCV IVSESKIIDL  60
   61 TNQEQDLSER IETNDTAKGA VFKLMKSDFY EREDFMGEVE DMITLKDIFG TETLKRSILF 120
  121 SFQYELDFLL RQFHQNVENI TIVGQKGTIM PIEARAMDAT LAVILKKVKL IEITMPPFAS 180
  181 HHTKLIINFY DNGECKIFLP SNNFTSMETN LPQQVCWCSP LL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 289.9897
Match: 1jy1A_
Description: Tyrosyl-DNA phosphodiesterase TDP1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
3'-tyrosyl-DNA phosphodiesterase activity 1.46693175347055 bayes_pls_golite062009
tyrosyl-DNA phosphodiesterase activity 1.46693175347055 bayes_pls_golite062009
structure-specific DNA binding 1.41591686174898 bayes_pls_golite062009
double-stranded DNA binding 1.29668490323599 bayes_pls_golite062009
single-stranded DNA binding 1.29429720882252 bayes_pls_golite062009
catalytic activity 1.29236214516383 bayes_pls_golite062009
binding 1.26667168593698 bayes_pls_golite062009
nucleic acid binding 0.926017334343152 bayes_pls_golite062009
DNA binding 0.840595330626189 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.235198647671849 bayes_pls_golite062009
protein binding 0.162885453822356 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [223-268]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KIGKEGLPVP FKRSLIEYLN SYHLKDIDEL ITKSVEEVNF APLSEL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 289.9897
Match: 1jy1A_
Description: Tyrosyl-DNA phosphodiesterase TDP1
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [269-287]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EFVYSTPSKF QSSGLLSFY

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [461-486]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YTSANLSQTA WGTVSRKPRN YEAGVL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 289.9897
Match: 1jy1A_
Description: Tyrosyl-DNA phosphodiesterase TDP1
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [288-460]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKLEKLSAGT SASDTAKHYL CQTSSIGTSL SRARDENLWT HLMIPLFTGI MSPPAKDTAG  60
   61 RKKAEILPTN SLINEYSQRK IKPYIIFPTE QEFVTSPLKW SSSGWFHFQY LQKKSYYEML 120
  121 RNKFKVFYKQ DPAMVTRRRG TTPAHSKFYM HCATNSAGPC DASQVFKELE WCL

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [487-544]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YHSRRLANTR KVTCRTFTRD RRGCAGNPTH VAVPFTLPVI PYDLAEDECF CLARHEND

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 289.9897
Match: 1jy1A_
Description: Tyrosyl-DNA phosphodiesterase TDP1
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle