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Protein Overview: EG10631

General Information:
Name(s) found: nadB / EG10631 [EcoGene]
Description(s) found:
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  • quinolinate synthase, L-aspartate oxidase (B protein) subunit / L-aspartate oxidase, FAD-dependent; quinolinate synthase flavoprotein subunit, B protein; LASPO [EcoGene]
  • quinolinate synthase, L-aspartate oxidase (B protein) subunit [Escherichia coli K12] [nr-271106-contam.fasta]
  • L-aspartate oxidase [Escherichia coli K12] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • quinolinate synthase, L-aspartate oxidase (B protein) subunit [Escherichia coli str. K-12 substr. MG1655] [Ecoli-contam-Dam1-Mind-COMA-MBP-110.fasta]
    • Organism: Escherichia coli str. K-12 substr. MG1655
    Length: 540 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEA]
    Biological Process: de novo NAD biosynthetic process from aspartate [IMPLink to PubMed article]
    oxidation reduction [IEA]
    Molecular Function: FAD binding [IDALink to PubMed article]
    electron carrier activity [IEA]
    L-aspartate oxidase activity [IDALink to PubMed article][IEA][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNTLPEHSCD VLIIGSGAAG LSLALRLADQ HQVIVLSKGP VTEGSTFYAQ GGIAAVFDET  60
   61 DSIDSHVEDT LIAGAGICDR HAVEFVASNA RSCVQWLIDQ GVLFDTHIQP NGEESYHLTR 120
  121 EGGHSHRRIL HAADATGREV ETTLVSKALN HPNIRVLERS NAVDLIVSDK IGLPGTRRVV 180
  181 GAWVWNRNKE TVETCHAKAV VLATGGASKV YQYTTNPDIS SGDGIAMAWR AGCRVANLEF 240
  241 NQFHPTALYH PQARNFLLTE ALRGEGAYLK RPDGTRFMPD FDERGELAPR DIVARAIDHE 300
  301 MKRLGADCMF LDISHKPADF IRQHFPMIYE KLLGLGIDLT QEPVPIVPAA HYTCGGVMVD 360
  361 DHGRTDVEGL YAIGEVSYTG LHGANRMASN SLLECLVYGW SAAEDITRRM PYAHDISTLP 420
  421 PWDESRVENP DERVVIQHNW HELRLFMWDY VGIVRTTKRL ERALRRITML QQEIDEYYAH 480
  481 FRVSNNLLEL RNLVQVAELI VRCAMMRKES RGLHFTLDYP ELLTHSGPSI LSPGNHYINR 540
  541

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..540] PSI-BLAST 142.0 L-aspartate oxidase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • succinate dehydrogenase activity
    		•  10.1355816274563 bayes_pls_golite062009
  • L-aspartate oxidase activity
    		•  7.97437641217089 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-CH group of donors
    		•  7.4746833070215 bayes_pls_golite062009
  • aspartate oxidase activity
    		•  7.32727957948448 bayes_pls_golite062009
  • succinate dehydrogenase (ubiquinone) activity
    		•  7.26739070786089 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor
    		•  7.26739070786089 bayes_pls_golite062009
  • oxidoreductase activity
    		•  6.1068533307878 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  5.74880353813045 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
    		•  5.00880700655468 bayes_pls_golite062009
  • electron carrier activity
    		•  2.8553929424231 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor
    		•  2.26549080531565 bayes_pls_golite062009
  • oxygen-dependent protoporphyrinogen oxidase activity
    		•  2.16428165652808 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors
    		•  2.11247286526577 bayes_pls_golite062009
  • dihydrolipoyl dehydrogenase activity
    		•  1.91979117253135 bayes_pls_golite062009
  • catalytic activity
    		•  1.75556359035561 bayes_pls_golite062009
  • binding
    		•  1.41440014472974 bayes_pls_golite062009
  • transporter activity
    		•  0.890824576391732 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors
    		•  0.798505263716232 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.706117386114413 bayes_pls_golite062009
  • fumarate reductase (NADH) activity
    		•  0.65260793370113 bayes_pls_golite062009
  • FAD binding
    		•  0.503028015880333 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.491481205015383 bayes_pls_golite062009
  • succinate-CoA ligase activity
    		•  0.468246082354334 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.26114823844682 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  0.224438371728402 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  0.164825358655637 bayes_pls_golite062009
  • protein binding
    		•  0.159209309982354 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.52

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle