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Protein Overview: EG12424

General Information:
Name(s) found: prmC / EG12424 [EcoGene]
Description(s) found:
Found 5 descriptions.
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  • RF-1 and RF-2 N5-glutamine methyltransferase / Release factor (RF1, RF2) glutamine methyltransferase [EcoGene]
    • Organism: Escherichia coli str. K-12 substr. MG1655
    Length: 277 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: protein amino acid methylation [IEA]
    methylation [IEA]
    Molecular Function: nucleic acid binding [IEA]
    protein binding [IPILink to PubMed article]
    protein methyltransferase activity [IEA]
    methyltransferase activity [IEA]
    transferase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEYQHWLREA ISQLQASESP RRDAEILLEH VTGRGRTFIL AFGETQLTDE QCQQLDALLT  60
   61 RRRDGEPIAH LTGVREFWSL PLFVSPATLI PRPDTECLVE QALARLPEQP CRILDLGTGT 120
  121 GAIALALASE RPDCEIIAVD RMPDAVSLAQ RNAQHLAIKN IHILQSDWFS ALAGQQFAMI 180
  181 VSNPPYIDEQ DPHLQQGDVR FEPLTALVAA DSGMADIVHI IEQSRNALVS GGFLLLEHGW 240
  241 QQGEAVRQAF ILAGYHDVET CRDYGDNERV TLGRYYQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..277] PSI-BLAST 65.221849 Crystal Structure Analysis of E.coli Protein (N5)-Glutamine Methyltransferase (HemK)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • S-adenosylmethionine-dependent methyltransferase activity
    		•  4.81722723955895 bayes_pls_golite062009
  • methyltransferase activity
    		•  4.64500705012502 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  4.57389022626587 bayes_pls_golite062009
  • DNA-methyltransferase activity
    		•  3.31632172292823 bayes_pls_golite062009
  • N-methyltransferase activity
    		•  3.00112136063228 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  2.74535979387581 bayes_pls_golite062009
  • transferase activity
    		•  2.42370637689376 bayes_pls_golite062009
  • site-specific DNA-methyltransferase (adenine-specific) activity
    		•  2.17404404470337 bayes_pls_golite062009
  • catalytic activity
    		•  1.62377578202456 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  1.42140847541194 bayes_pls_golite062009
  • arginine N-methyltransferase activity
    		•  1.40233857644962 bayes_pls_golite062009
  • protein-arginine N-methyltransferase activity
    		•  1.40233857644962 bayes_pls_golite062009
  • RNA methyltransferase activity
    		•  1.36067005317038 bayes_pls_golite062009
  • rRNA methyltransferase activity
    		•  0.740099749645209 bayes_pls_golite062009
  • histone-arginine N-methyltransferase activity
    		•  0.67380437956274 bayes_pls_golite062009
  • DNA (cytosine-5-)-methyltransferase activity
    		•  0.6110460718981 bayes_pls_golite062009
  • protein-arginine omega-N monomethyltransferase activity
    		•  0.355464145533041 bayes_pls_golite062009
  • O-methyltransferase activity
    		•  0.32686871890222 bayes_pls_golite062009
  • protein-arginine omega-N symmetric methyltransferase activity
    		•  0.255084448603261 bayes_pls_golite062009
  • binding
    		•  0.207713650201315 bayes_pls_golite062009
  • rRNA (guanine) methyltransferase activity
    		•  0.11336280953361 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle