YRC Public Data Repository - Protein Structure Prediction

Protein:	EG12424
Organism:	Escherichia coli str. K-12 substr. MG1655
Length:	277 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EG12424.

Description	E-value	Query Range	Subject Range
gi\|196113152, gi... - gi\|88796062\|ref\|ZP_01111746.1\| peptide release factor-glutamine N5-methyltransferase [Alteromonas ma...	266.0	[0..1]	[276..1]
PRMC_VIBF1 - Release factor glutamine methyltransferase OS=Vibrio fischeri (strain ATCC 700601 / ES114) GN=prmC P...	257.0	[0..1]	[275..3]
gi\|28805730 - gi\|28805730\|dbj\|BAC59007.1\| HemK protein [Vibrio parahaemolyticus RIMD 2210633] gi\|28805730, gi\|... - gi\|28897518\|ref\|NP_797123.1\| HemK protein [Vibrio parahaemolyticus RIMD 2210633], gi\|28805730\|dbj\|BA...	255.0	[0..2]	[276..6]
gi\|94427880, gi\|... - gi\|94500022\|ref\|ZP_01306557.1\| modification methylase, HemK family protein [Oceanobacter sp. RED65],...	254.0	[0..2]	[276..5]
gi\|91228928, gi\|... - gi\|91228928\|ref\|ZP_01262826.1\| HemK protein [Vibrio alginolyticus 12G01], gi\|91187511\|gb\|EAS73845.1\|...	253.0	[0..2]	[273..6]
gi\|37525988, gi\|... - gi\|37525988\|ref\|NP_929332.1\| N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase [Photo...	253.0	[0..1]	[276..1]
gi\|254230551, gi... - gi\|75854051\|ref\|ZP_00761773.1\| COG2890: Methylase of polypeptide chain release factors [Vibrio sp. E...	252.0	[0..2]	[275..6]
gi\|69166078, gi\|... - gi\|69950397\|ref\|ZP_00638296.1\| Modification methylase HemK [Shewanella frigidimarina NCIMB 400], gi\|...	251.0	[0..2]	[275..8]
gi\|27359849, gi\|... - gi\|27363733\|ref\|NP_759261.1\| methylase of polypeptide chain release factor [Vibrio vulnificus CMCP6]...	251.0	[0..1]	[275..5]
gi\|37197858, gi\|... - gi\|37679116\|ref\|NP_933725.1\| methylase of polypeptide chain release factor [Vibrio vulnificus YJ016]...	250.0	[0..1]	[275..5]

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Predicted Domain #1

Region A:
Residues: [1-277]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEYQHWLREA ISQLQASESP RRDAEILLEH VTGRGRTFIL AFGETQLTDE QCQQLDALLT  60
   61 RRRDGEPIAH LTGVREFWSL PLFVSPATLI PRPDTECLVE QALARLPEQP CRILDLGTGT 120
  121 GAIALALASE RPDCEIIAVD RMPDAVSLAQ RNAQHLAIKN IHILQSDWFS ALAGQQFAMI 180
  181 VSNPPYIDEQ DPHLQQGDVR FEPLTALVAA DSGMADIVHI IEQSRNALVS GGFLLLEHGW 240
  241 QQGEAVRQAF ILAGYHDVET CRDYGDNERV TLGRYYQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	65.221849
Match:	1t43A
Description:	Crystal Structure Analysis of E.coli Protein (N5)-Glutamine Methyltransferase (HemK)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
S-adenosylmethionine-dependent methyltransferase activity	4.81722723955895	bayes_pls_golite062009
methyltransferase activity	4.64500705012502	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	4.57389022626587	bayes_pls_golite062009
DNA-methyltransferase activity	3.31632172292823	bayes_pls_golite062009
N-methyltransferase activity	3.00112136063228	bayes_pls_golite062009
protein methyltransferase activity	2.74535979387581	bayes_pls_golite062009
transferase activity	2.42370637689376	bayes_pls_golite062009
site-specific DNA-methyltransferase (adenine-specific) activity	2.17404404470337	bayes_pls_golite062009
catalytic activity	1.62377578202456	bayes_pls_golite062009
histone methyltransferase activity	1.42140847541194	bayes_pls_golite062009
arginine N-methyltransferase activity	1.40233857644962	bayes_pls_golite062009
protein-arginine N-methyltransferase activity	1.40233857644962	bayes_pls_golite062009
RNA methyltransferase activity	1.36067005317038	bayes_pls_golite062009
rRNA methyltransferase activity	0.740099749645209	bayes_pls_golite062009
histone-arginine N-methyltransferase activity	0.67380437956274	bayes_pls_golite062009
DNA (cytosine-5-)-methyltransferase activity	0.6110460718981	bayes_pls_golite062009
protein-arginine omega-N monomethyltransferase activity	0.355464145533041	bayes_pls_golite062009
O-methyltransferase activity	0.32686871890222	bayes_pls_golite062009
protein-arginine omega-N symmetric methyltransferase activity	0.255084448603261	bayes_pls_golite062009
binding	0.207713650201315	bayes_pls_golite062009
rRNA (guanine) methyltransferase activity	0.11336280953361	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: