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Protein Overview: EG10699

General Information:
Name(s) found: pfkA / EG10699 [EcoGene]
Description(s) found:
Found 6 descriptions.
SHOW ALL
  • 6-phosphofructokinase I / 6-phosphofructokinase-1; allosteric: activated by MgNDPs, inhibited by PEP; homoterameric [EcoGene]
    • Organism: Escherichia coli str. K-12 substr. MG1655
    Length: 320 amino acids

    Gene Ontology:
    Cellular Component: 6-phosphofructokinase complex [IDALink to PubMed article][IEA]
    cytoplasm [IDALink to PubMed article]
    Biological Process: carbohydrate catabolic process [IMPLink to PubMed article]
    glycolysis [IDALink to PubMed article][IEA]
    cellular carbohydrate catabolic process [IMPLink to PubMed article]
    fructose 6-phosphate metabolic process [IEA]
    glucose catabolic process [IMPLink to PubMed article]
    Molecular Function: magnesium ion binding [IDALink to PubMed article][IEA]
    NAD+ kinase activity [ISSLink to PubMed article]
    ATP binding [IEA][IMPLink to PubMed article]
    identical protein binding [IDALink to PubMed article]
    protein binding [IPILink to PubMed article]
    ribonucleotide binding [IDALink to PubMed article]
    binding [IDALink to PubMed article]
    6-phosphofructokinase activity [IEA][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIKKIGVLTS GGDAPGMNAA IRGVVRSALT EGLEVMGIYD GYLGLYEDRM VQLDRYSVSD  60
   61 MINRGGTFLG SARFPEFRDE NIRAVAIENL KKRGIDALVV IGGDGSYMGA MRLTEMGFPC 120
  121 IGLPGTIDND IKGTDYTIGF FTALSTVVEA IDRLRDTSSS HQRISVVEVM GRYCGDLTLA 180
  181 AAIAGGCEFV VVPEVEFSRE DLVNEIKAGI AKGKKHAIVA ITEHMCDVDE LAHFIEKETG 240
  241 RETRATVLGH IQRGGSPVPY DRILASRMGA YAIDLLLAGY GGRCVGIQNE QLVHHDIIDA 300
  301 IENMKRPFKG DWLDCAKKLY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..320] PSI-BLAST 114.0 ATP-dependent phosphofructokinase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • 6-phosphofructokinase activity
    		•  12.7403693686468 bayes_pls_golite062009
  • phosphofructokinase activity
    		•  11.7059647240147 bayes_pls_golite062009
  • carbohydrate kinase activity
    		•  9.54757838113048 bayes_pls_golite062009
  • fructose-6-phosphate binding
    		•  7.12870468168491 bayes_pls_golite062009
  • fructose binding
    		•  7.0070117394116 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  2.40595318732289 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  2.20407391743017 bayes_pls_golite062009
  • kinase activity
    		•  2.09076306615481 bayes_pls_golite062009
  • transferase activity
    		•  1.97789134877808 bayes_pls_golite062009
  • catalytic activity
    		•  1.89212073381079 bayes_pls_golite062009
  • monosaccharide binding
    		•  0.93954836516667 bayes_pls_golite062009
  • binding
    		•  0.692710585652872 bayes_pls_golite062009
  • hydrolase activity
    		•  0.276140444059183 bayes_pls_golite062009
  • fructose-2,6-bisphosphate 2-phosphatase activity
    		•  0.13423626204854 bayes_pls_golite062009
  • sugar binding
    		•  0.0026978348896064 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.72

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle