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Protein Overview: EG10429

General Information:
Name(s) found: hemC / EG10429 [EcoGene]
Description(s) found:
Found 5 descriptions.
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  • hydroxymethylbilane synthase / Porphobilinogen deaminase; neomycin sensitivity [EcoGene]
    • Organism: Escherichia coli str. K-12 substr. MG1655
    Length: 313 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: porphyrin biosynthetic process [IEA]
    peptidyl-pyrromethane cofactor linkage [IDALink to PubMed article]
    heme biosynthetic process [IMPLink to PubMed article]
    tetrapyrrole biosynthetic process [IMPLink to PubMed article]
    Molecular Function: hydroxymethylbilane synthase activity [IEA][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLDNVLRIAT RQSPLALWQA HYVKDKLMAS HPGLVVELVP MVTRGDVILD TPLAKVGGKG  60
   61 LFVKELEVAL LENRADIAVH SMKDVPVEFP QGLGLVTICE REDPRDAFVS NNYDSLDALP 120
  121 AGSIVGTSSL RRQCQLAERR PDLIIRSLRG NVGTRLSKLD NGEYDAIILA VAGLKRLGLE 180
  181 SRIRAALPPE ISLPAVGQGA VGIECRLDDS RTRELLAALN HHETALRVTA ERAMNTRLEG 240
  241 GCQVPIGSYA ELIDGEIWLR ALVGAPDGSQ IIRGERRGAP QDAEQMGISL AEELLNNGAR 300
  301 EILAEVYNGD APA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..313] PSI-BLAST 136.0 REDUCED FORM SELENOMETHIONINE-LABELLED HYDROXYMETHYLBILANE SYNTHASE DETERMINED BY MAD

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  3.22743737647397 bayes_pls_golite062009
  • DNA binding
    		•  2.86883926687971 bayes_pls_golite062009
  • transcription factor activity
    		•  2.7948293378347 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.66637887681284 bayes_pls_golite062009
  • binding
    		•  2.63182502368928 bayes_pls_golite062009
  • hydroxymethylbilane synthase activity
    		•  2.03196514141563 bayes_pls_golite062009
  • catalytic activity
    		•  0.674312982669564 bayes_pls_golite062009
  • transcription activator activity
    		•  0.050905489018976 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle