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Protein Overview: EG14210

General Information:
Name(s) found: pbpC / EG14210 [EcoGene]
Description(s) found:
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  • penicillin-insensitive murein repair transglycosylase; inactive transpeptidase domain protein / Penicillin-insensitive murein repair transglycosylase; inactive transpeptidase domain [EcoGene]
  • fused transglycosylase/transpeptidase [Escherichia coli K12] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • fused transglycosylase/transpeptidase [Escherichia coli str. K-12 substr. MG1655] [Ecoli-contam-Dam1-Mind-COMA-MBP-110.fasta]
  • penicillin-binding protein PBP1C murein transglycosylase; inactive transpeptidase domain [Escherichia coli str. K-12 substr. MG1655] [c_elegans-WS236-ecoli-05Mar2013-contam.fasta]
    • Organism: Escherichia coli str. K-12 substr. MG1655
    Length: 770 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEA]
    peptidoglycan-based cell wall [IEA]
    integral to membrane [IEA]
    plasma membrane [IEA]
    Biological Process: regulation of cell shape [IEA]
    peptidoglycan biosynthetic process [IEA][IMPLink to PubMed article]
    Molecular Function: drug binding [IDALink to PubMed articleLink to PubMed article]
    peptidoglycan glycosyltransferase activity [IDALink to PubMed article]
    penicillin binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPRLLTKRGC WITLAAAPFL LFLAAWGADK LWPLPLHEVN PARVVVAQDG TPLWRFADAD  60
   61 GIWRYPVTIE DVSPRYLEAL INYEDRWFWK HPGVNPFSVA RAAWQDLTSG RVISGGSTLT 120
  121 MQVARLLDPH PKTFGGKIRQ LWRALQLEWH LSKREILTLY LNRAPFGGTL QGIGAASWAY 180
  181 LGKSPANLSY SEAAMLAVLP QAPSRLRPDR WPERAEAARN KVLERMAVQG VWSREQVKES 240
  241 REEPIWLAPR QMPQLAPLFS RMMLGKSKSD KITTTLDAGL QRRLEELAQN WKGRLPPRSS 300
  301 LAMIVVDHTD MRVRGWVGSV DLNDDSRFGH VDMVNSIRSP GSVLKPFVYG LALDEGLIHP 360
  361 ASLLQDVPRR TGDYRPGNFD SGFHGPISMS EALVRSLNLP AVQVLEAYGP KRFAAKLRNV 420
  421 GLPLYLPNGA APNLSLILGG AGAKLEDMAA AYTAFARHGK AGKLRLQPDD PLLERPLMSS 480
  481 GAAWIIRRIM ADEAQPLPDS ALPRVAPLAW KTGTSYGYRD AWAIGVNARY VIGIWTGRPD 540
  541 GTPVVGQFGF ASAVPLLNQV NNILLSRSAN LPEDPRPNSV TRGVICWPGG QSLPEGDGNC 600
  601 RRRLATWLLD GSQPPTLLLP EQEGINGIRF PIWLDENGKR VAADCPQARQ EMINVWPLPL 660
  661 EPWLPASERR AVRLPPASTS CPPYGHDAQL PLQLTGVRDG AIIKRLPGAA EATLPLQSSG 720
  721 GAGERWWFLN GEPLTERGRN VTLHLTDKGD YQLLVMDDVG QIATVKFVMQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..589] PSI-BLAST 98.09691 No description for 2oluA was found.
    2 View Details [590..770] FFAS03 1.48 CD3 gamma chain ectodomain fragment; CD3 epsilon chain ectodomain fragment

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • hydrolase activity, hydrolyzing O-glycosyl compounds
    		•  3.77507319667289 bayes_pls_golite062009
  • hydrolase activity, acting on glycosyl bonds
    		•  3.4039757547751 bayes_pls_golite062009
  • serine-type D-Ala-D-Ala carboxypeptidase activity
    		•  3.12650314537616 bayes_pls_golite062009
  • penicillin binding
    		•  2.89507018520983 bayes_pls_golite062009
  • serine-type carboxypeptidase activity
    		•  2.70174066798582 bayes_pls_golite062009
  • serine-type exopeptidase activity
    		•  2.69091897402517 bayes_pls_golite062009
  • drug binding
    		•  2.27792716125407 bayes_pls_golite062009
  • carboxypeptidase activity
    		•  1.96547160092829 bayes_pls_golite062009
  • catalytic activity
    		•  1.85492008367309 bayes_pls_golite062009
  • exopeptidase activity
    		•  1.44522375970439 bayes_pls_golite062009
  • binding
    		•  0.967786931456022 bayes_pls_golite062009
  • peptidase activity
    		•  0.88898857866944 bayes_pls_golite062009
  • hydrolase activity
    		•  0.852674113261898 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  0.710917280650211 bayes_pls_golite062009
  • chitinase activity
    		•  0.42465610730229 bayes_pls_golite062009
  • protein binding
    		•  0.274057433888583 bayes_pls_golite062009
    2
    Term Confidence Notes
  • binding
    		•  2.27173620923431 bayes_pls_golite062009
  • protein binding
    		•  1.31579477754421 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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