Protein Overview: DNM3A_RAT

General Information:
Name(s) found:	DNM3A_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|51556225\|ref\|NP_001003958.1\| DNA (cytosine-5-)-methyltransferase 3 alpha isoform 1 [Rattus norvegicus] [NCBI NR] gi\|50539389\|tpe\|CAE52317.1\| TPA: putative DNA (cytosine-5) methyltransferase 3a [Rattus norvegicus] [NCBI NR] gi\|123778851\|sp\|Q1LZ53.1\|DNM3A_RAT RecName: Full=DNA (cytosine-5)-methyltransferase 3A; Short=Dnmt3a [NCBI NR] DNA (cytosine-5)-methyltransferase 3A OS=Rattus norvegicus GN=Dnmt3a PE=1 SV=1 [Swiss-Prot] DNA methyltransferase 3A isoform 1 [Rattus norvegicus]gi\|50539389\|tpe\|CAE52317.1\| TPA: putative DNA (cytosine-5) methyltransferase 3a [Rattus norvegicus] [nrdb_11152004_Chlamydomonas] Tax_Id=10116 DNA methyltransferase 3A isoform 1 [EBI-IPI_rat_3.05_04-04-2005_origrev.fasta] DNA (cytosine-5)-methyltransferase 3A (Dnmt3a) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] DNA methyltransferase 3A isoform 1 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] TPA: putative DNA (cytosine-5) methyltransferase 3a [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 DNA METHYLTRANSFERASE 3A ISOFORM 1 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] DNA (cytosine-5-)-methyltransferase 3 alpha isoform 1 [Rattus norvegicus] [NCBI-RefSeq_human-rat_na_04-07-2009_con_reversed.fasta] Isoform 1 of DNA (cytosine-5)-methyltransferase 3A OS=Rattus norvegicus GN=Dnmt3a [011711_HMR.fasta] DNA (cytosine-5)-methyltransferase 3A OS=Rattus norvegicus GN=Dnmt3a PE=2 SV=1 [UNIPROT_RAT_07-21-2011_reversed.fasta]
Organism:	Rattus norvegicus
Length:	908 amino acids
Gene Ontology:
Cellular Component:	heterochromatin [UNKNOWN] nucleus [UNKNOWN][IDA][ISS] euchromatin [UNKNOWN][ISS] cytoplasm [UNKNOWN][ISS] nuclear matrix [UNKNOWN][ISS] chromosome, centromeric region [IEA] nuclear heterochromatin [UNKNOWN][IEA]
Biological Process:	negative regulation of transcription from RNA polymerase II promoter [UNKNOWN][IEA] chromatin modification [IEA] regulation of gene expression by genetic imprinting [UNKNOWN][IEA] DNA methylation [UNKNOWN][ISS] S-adenosylhomocysteine metabolic process [IDA] spermatogenesis [UNKNOWN][IEA] DNA methylation on cytosine within a CG sequence [IDA] DNA methylation involved in gamete generation [IEA] DNA methylation involved in embryonic development [UNKNOWN][IEA] S-adenosylmethioninamine metabolic process [IDA] regulation of transcription [IEA] methylation-dependent chromatin silencing [UNKNOWN][IEA]
Molecular Function:	DNA binding [UNKNOWN][ISS] DNA (cytosine-5-)-methyltransferase activity [UNKNOWN][ISS] zinc ion binding [IEA] protein binding [UNKNOWN][IEA] metal ion binding [IEA] DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates [IDA] methyltransferase activity [IEA] unmethylated CpG binding [IDA] chromatin binding [UNKNOWN][IEA] transferase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPSSGPGDTS ISSLEREDDR KEGEEQEENR GKEERQEPSA TARKVGRPGR KRKHPPVESS  60
   61 DTPKDPAVTT KSQPTAQDSG PSDLLPNGDL EKRSEPQPEE GSPAAGQKGG APAEGEGTET 120
  121 PPEASRAVEN GCCVTKEGRG ASAGEGKEQK QTNIESMKME GSRGRLRGGL GWESSLRQRP 180
  181 MPRLTFQAGD PYYISKRKRD EWLARWKREA EKKAKVIAVM NAVEESQASG ESQKVEEASP 240
  241 PAVQQPTDPA SPTVATTPEP VGADAGDKNA TKAADDEPEY EDGRGFGIGE LVWGKLRGFS 300
  301 WWPGRIVSWW MTGRSRAAEG TRWVMWFGDG KFSVVCVEKL MPLSSFCSAF HQATYNKQPM 360
  361 YRKAIYEVLQ VASSRAGKLF PACHDSDESD TGKAVEVQNK QMIEWALGGF QPSGPKGLEP 420
  421 PEEEKNPYKE VYTDMWVEPE AAAYAPPPPA KKPRKSTTEK PKVKEIIDER TRERLVYEVR 480
  481 QKCRNIEDIC ISCGSLNVTL EHPLFIGGMC QNCKNCFLEC AYQYDDDGYQ SYCTICCGGR 540
  541 EVLMCGNNNC CRCFCVECVD LLVGPGAAQA AIKEDPWNCY MCGHKGTYGL LRRREDWPSR 600
  601 LQMFFANNHD QEFDPPKVYP PVPAEKRKPI RVLSLFDGIA TGLLVLKDLG IQVDRYIASE 660
  661 VCEDSITVGM VRHQGKIMYV GDVRSVTQKH IQEWGPFDLV IGGSPCNDLS IVNPARKGLY 720
  721 EGTGRLFFEF YRLLHDARPK EGDDRPFFWL FENVVAMGVS DKRDISRFLE SNPVMIDAKE 780
  781 VSAAHRARYF WGNLPGMNRP LASTVNDKLE LQECLEHGRI AKFSKVRTIT TRSNSIKQGK 840
  841 DQHFPVFMNE KEDILWCTEM ERVFGFPVHY TDVSNMSRLA RQRLLGRSWS VPVIRHLFAP 900
  901 LKEYFACV

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: DNM3A_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: