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Protein Overview: AFG3L2

General Information:
Name(s) found: AFG3L2 [HGNC (HUGO)]
Description(s) found:
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  • gi|40675546|gb|AAH65016.1| AFG3 ATPase family gene 3-like 2 (yeast) [Homo sapiens] [NCBI NR]
  • gi|126302516|sp|Q9Y4W6.2|AFG32_HUMAN RecName: Full=AFG3-like protein 2; AltName: Full=Paraplegin-like protein [NCBI NR]
  • AFG3 ATPase family gene 3-like 2 (yeast) [HGNC (HUGO)]
  • AFG3-like protein 2 OS=Homo sapiens GN=AFG3L2 PE=1 SV=2 [Swiss-Prot]
  • AFG3 ATPase family gene 3-like 2 [Homo sapiens] [nrdb_11152004_Chlamydomonas]
  • AFG3 ATPase family gene 3-like 2 (yeast) [Homo sapiens] [NCBI-RefSeq_human_na_05-03-2007_con_reversed.fasta]
  • AFG3-like protein 2 (Paraplegin-like protein) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • RecName: Full=AFG3-like protein 2; AltName: Full=Paraplegin-like protein [NCBI-RefSeq_human_na_10-15-2008_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=AFG3L2 AFG3-like protein 2 [human-ipi-250309-contam.fasta]
  • IPI:IPI00001091.4|SWISS-PROT:Q9Y4W6|TREMBL:Q8TA92|ENSEMBL:ENSP00000269143|REFSEQ:NP_006787|H-INV:HIT000326080|VEGA:OTTHUMP00000071704;OTTHUMP00000162476 Tax_Id=9606 Gene_Symbol=AFG3L2 AFG3-like protein 2 [ipi.HUMAN.fasta.20090807]
  • Tax_Id=9606 AFG3-like protein 2 [IPI_human_3.26.fasta]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=AFG3L2 AFG3-like protein 2 ENSG00000141385 IPI00001091 [drosphohumanreversed.fasta]
  • Q9Y4W6;Q6P1L0; RecName: Full=AFG3-like protein 2; AltName: Full=Paraplegin-like protein; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • AFG3-like protein 2 OS=Homo sapiens GN=AFG3L2 [011711_HMR.fasta]
  • IPI:IPI00001091.4|SWISS-PROT:Q9Y4W6|TREMBL:D3DUJ0;Q8TA92|ENSEMBL:ENSP00000269143|REFSEQ:NP_006787|H-INV:HIT000326080|VEGA:OTTHUMP00000071704;OTTHUMP00000162476 Tax_Id=9606 Gene_Symbol=AFG3L2 AFG3-like protein 2 [ipi.HUMAN.fasta.20100406]
  • GeneSymbol=AFG3L2 Synonyms=FLJ25993|SCA28 AFG3-like protein 2 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00001091.4|SWISS-PROT:Q9Y4W6|TREMBL:D3DUJ0|ENSEMBL:ENSP00000269143|REFSEQ:NP_006787|H-INV:HIT000326080|VEGA:OTTHUMP00000162476 Tax_Id=9606 Gene_Symbol=AFG3L2 AFG3-like protein 2 [ipi.HUMAN.20110912.fasta]
  • AFG3-like protein 2 GN=AFG3L2 [Doctor+uniprot-HUMAN-120911.fasta]
    • Organism: Homo sapiens
    Length: 797 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAHRCLRLWG RGGCWPRGLQ QLLVPGGVGP GEQPCLRTLY RFVTTQARAS RNSLLTDIIA  60
   61 AYQRFCSRPP KGFEKYFPNG KNGKKASEPK EVMGEKKESK PAATTRSSGG GGGGGGKRGG 120
  121 KKDDSHWWSR FQKGDIPWDD KDFRMFFLWT ALFWGGVMFY LLLKRSGREI TWKDFVNNYL 180
  181 SKGVVDRLEV VNKRFVRVTF TPGKTPVDGQ YVWFNIGSVD TFERNLETLQ QELGIEGENR 240
  241 VPVVYIAESD GSFLLSMLPT VLIIAFLLYT IRRGPAGIGR TGRGMGGLFS VGETTAKVLK 300
  301 DEIDVKFKDV AGCEEAKLEI MEFVNFLKNP KQYQDLGAKI PKGAILTGPP GTGKTLLAKA 360
  361 TAGEANVPFI TVSGSEFLEM FVGVGPARVR DLFALARKNA PCILFIDEID AVGRKRGRGN 420
  421 FGGQSEQENT LNQLLVEMDG FNTTTNVVIL AGTNRPDILD PALLRPGRFD RQIFIGPPDI 480
  481 KGRASIFKVH LRPLKLDSTL EKDKLARKLA SLTPGFSGAD VANVCNEAAL IAARHLSDSI 540
  541 NQKHFEQAIE RVIGGLEKKT QVLQPEEKKT VAYHEAGHAV AGWYLEHADP LLKVSIIPRG 600
  601 KGLGYAQYLP KEQYLYTKEQ LLDRMCMTLG GRVSEEIFFG RITTGAQDDL RKVTQSAYAQ 660
  661 IVQFGMNEKV GQISFDLPRQ GDMVLEKPYS EATARLIDDE VRILINDAYK RTVALLTEKK 720
  721 ADVEKVALLL LEKEVLDKND MVELLGPRPF AEKSTYEEFV EGTGSLDEDT SLPEGLKDWN 780
  781 KEREKEKEEP PGEKVAN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..162] FFAS03 0.993 30S subunit
    2 View Details [163..295] deduced N/A No confident structure predictions are available.
    3 View Details [296..540] PSI-BLAST 64.39794 AAA domain of cell division protein FtsH
    4 View Details [541..640] FFAS03 4.47 No description for 2di4A was found.
    5 View Details [641..797] PSI-BLAST 86.69897 EDTA treated

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • hydrolase activity
    		•  2.32318595170495 bayes_pls_golite062009
  • binding
    		•  2.01755875920323 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.945162431169109 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.651147541256606 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.428373955572763 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.424644011903671 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.424583288440993 bayes_pls_golite062009
  • nucleotide binding
    		•  0.422354428195324 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.343417528390083 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.340322591037813 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.337450879590656 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.31055462644917 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.192553066860219 bayes_pls_golite062009
  • cation-transporting ATPase activity
    		•  0.178480894611265 bayes_pls_golite062009
  • protein binding
    		•  0.071010918255742 bayes_pls_golite062009
  • signal transducer activity
    		•  0.0529006651532686 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.0529006651532686 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of ions
    		•  0.0523354130179299 bayes_pls_golite062009
  • ATP binding
    		•  0.04834397972685 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.0149501427627318 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.00365326483311895 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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