Protein Overview: Ptpmeg-PB

General Information:
Name(s) found:	Ptpmeg-PB / FBpp0072442 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|85816189\|ref\|NP_728524.2\| ptpmeg, isoform B [Drosophila melanogaster] [NCBI NR] gi\|84796065\|gb\|AAN11443.2\| ptpmeg, isoform B [Drosophila melanogaster] [NCBI NR] gi\|28603686\|gb\|AAO47875.1\| LD13416p [Drosophila melanogaster] [NCBI NR] The gene Ptpmeg is referred to in FlyBase by the symbol Dmel\Ptpmeg (CG1228, FBgn0035133). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:328099..356050. It has the cytological map location 61C1. Based on sequence similarity, it is predicted to have molecular function</span>: protein tyrosine phosphatase activity; cytoskeletal protein binding. There is experimental evidence that it is involved in the biological process</span>: axon extension involved in axon guidance; mushroom body development; autophagic cell death; salivary gland cell autophagic cell death; central complex development. 40 alleles are reported. The phenotypes of these alleles are annotated with: eye; mushroom body beta-lobe; mushroom body medial lobe; mushroom body vertical lobe; mushroom body alpha-lobe. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase] LD13416p [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas] type=protein; loc=3L:join(328302..328352,352681..352771,352838..353687,353761..354446,354500..355124,355199..355376,355438..355527); ID=FBpp0072442; name=Ptpmeg-PB; parent=FBgn0035133,FBtr0072543; dbxref=FlyBase_Annotation_IDs:CG1228-PB,FlyBase:FBpp007244 [fly-100309-contam.fasta] Ptpmeg CG1228-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta] CG1228-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta] type=protein; loc=3L:join(328302..328352,352681..352771,352838..353687,353761..354446,354500..355124,355199..355376,355438..355527); ID=FBpp0072442; name=Ptpmeg-PB; parent=FBgn0035133,FBtr0072543; dbxref=FlyBase_Annotation_IDs:CG1228-PB,FlyBase:FBpp0072442,GB_protein:AAN11443.1,GB_protein:AAN11443.2,REFSEQ:NP_728524,GB_protein:AAN11443; MD5=ce8cd8492babe8b1dfb11d5e0f2f27f9; length=856; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=3L:join(328302..328352,352681..352771,352838..353687,353761..354446,354500..355124,355199..355376,355438..355527); ID=FBpp0072442; name=Ptpmeg-PB; parent=FBgn0035133,FBtr0072543; dbxref=FlyBase_Annotation_IDs:CG1228-PB,FlyBase:FBpp0072442,GB_protein:AAN11443.1,GB_protein:AAN11443.2,REFSEQ:NP_728524,GB_protein:AAN11443; MD5=ce8cd8492babe8b1dfb11d5e0f2f27f9; length=856; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] LD13416p OS=Drosophila melanogaster GN=Ptpmeg PE=2 SV=2 [UniProt_drosophila_07-01-2011_reversed.fasta]
Organism:	Drosophila melanogaster
Length:	856 amino acids
Gene Ontology:
Cellular Component:	cytoskeleton [IEA] cytoplasm [IEA] extrinsic to membrane [IEA]
Biological Process:	mushroom body development [IMP] autophagic cell death [IEP] central complex development [IMP] protein amino acid dephosphorylation [IEA][NAS] salivary gland cell autophagic cell death [IEP] axon extension involved in axon guidance [IMP]
Molecular Function:	protein tyrosine phosphatase activity [ISS][NAS] cytoskeletal protein binding [IEA][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPEACCFLHS SFILVMCFYL QIKRNILLGK LPCSSNTQCL LASYTVQSEL GDFNALEHQP  60
   61 GYLSGMQLLC DQTTEAERKV GELHKLHRGQ LPADAEYNYL EHAKRLELYG IDLHRATDSN 120
  121 GKELQLGVSA VGLLVFQHSL RVNTFSWSKM VKVSFKRKDF FIQLRREPSE NYDTLLGFGM 180
  181 SSHKHAKALW KSCVEHHSFF RLKRPHRLSR FLNISLGSKF YYSGRTELQA VQESKQRGRI 240
  241 HKVFVRSPSK RLLGAAGGVG TSGSSGGTPM QQHSGSESAN SHNNGKPAGA GTILTITKTS 300
  301 RPHDNKVTSK EADSMPRKAW EQQSDEYDIQ LDVGFIEQCT RRFESASPSP MPPAYSSGQH 360
  361 SPILLPTTIA DAVGHQQPES GSDLITIRLQ ADEQGRYGFN VKGGVDLSLP VQVSKVVPHT 420
  421 PADRCTPRVC EGDEVLMING RDVHGLRHEQ VVAMIRDCRH QASGELLLTV RPQRSAPLLL 480
  481 EEEPLYQYVP ESDEIGSHSN LLDGDALFTQ SLLLLSDGLA SGALLAQYEL MYRKNPDLAI 540
  541 TEARKPANAP KNRYRDISPY DCTRVSLVNS LTGDYINANY VNMEIPGGAV NRYIATQGPL 600
  601 ASTTTDFWRM VQQESSHLLV MLTTVMESGR QKCHQYWPVT GEELQLAEGF SVRCLSEKPD 660
  661 ETGSFVFREF VLKDKHEQRH IHHMQYLAWP DHCVPSDPNL FLEFTERVRA ARNRTLLQEI 720
  721 EESLKQVRLM DADADADENG GLMRERKCAA SNGATPEDET PVSTSVHQCI SAANPPVIVH 780
  781 CSAGIGRTGV LILMDTALAL MEAREPVYPL DIVRTMRDQR ACMVQNVSQY RFVCECICAA 840
  841 YMKISRSSAA INDDED

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.59

Protein Overview: Ptpmeg-PB

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: