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Protein Overview: FPGS3_ARATH

General Information:
Name(s) found: FPGS3_ARATH [Swiss-Prot]
Description(s) found:
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  • gi|30694288|ref|NP_567026.3| ATDFD (A. THALIANA DHFS-FPGS HOMOLOG D); tetrahydrofolylpolyglutamate synthase [Arabidopsis thaliana] [NCBI NR]
  • gi|17976761|emb|CAC82079.1| folylpolyglutamate synthetase, cytosolic isoform [Arabidopsis thaliana] [NCBI NR]
  • Folylpolyglutamate synthase OS=Arabidopsis thaliana GN=FPGS3 PE=1 SV=1 [Swiss-Prot]
  • folylpolyglutamate-dihydrofolate synthetase [Arabidopsis thaliana]gi|30694288|ref|NP_567026.3| dihydrofolate synthetase/folylpolyglutamate synthetase (DHFS/FPGS4) [Arabidopsis thaliana] [nrdb_11152004_Chlamydomonas]
  • | Symbols: ATDFD | ATDFD (A. THALIANA DHFS-FPGS HOMOLOG D); tetrahydrofolylpolyglutamate synthase | chr3:20647764-20650374 FORWARD [TAIR_Arabidopsis_na_04-12-2008_con_reversed.fasta]
  • ATDFD (A. THALIANA DHFS-FPGS HOMOLOG D); tetrahydrofolylpolyglutamate synthase [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • folylpolyglutamate synthetase, cytosolic isoform [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • | Symbols: ATDFD, DFD, FPGS3 | DHFS-FPGS homolog D | chr3:20636785-20639395 FORWARD LENGTH=492 [TAIR_A_Thaliana_10_12-14-2010_reversed.fasta]
    • Organism: Arabidopsis thaliana
    Length: 492 amino acids

    Gene Ontology:
    Cellular Component: cytosol [IDA]
    Biological Process: one-carbon metabolic process [TAS]
    Molecular Function: tetrahydrofolylpolyglutamate synthase activity [IGI]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATEDDGELS ARYQNTLDAL SSLITKRGRL ASNNQSHRFR LLFHYLKVLE LEDAVSQMKI  60
   61 IHVAGTKGKG STCTFAESIL RCYGLRTGLF TSPHLIDVRE RFRLNGIEIS QEKFVNYFWC 120
  121 CFHKLKEKTS NEVPMPTYFC FLALLAFKIF TTEQVDVVIL EVGLGGRFDA TNVIQKPVVC 180
  181 GISSLGYDHM EILGYTLAEI AAEKAGIFKS GVPAFTVAQP DEAMRVLNEK ASKLEVNLQV 240
  241 VEPLDSSQRL GLQGEHQYLN AGLAVALCST FLKEIGIEDK NGLDQTNGLP EKFISGLSNA 300
  301 YLMGRAMIVP DSELPEEIVY YLDGAHSPES MEACAIWFSK QIKQNQERNQ KRSEQILLFN 360
  361 CMSVRDPSLL LPRLRSKCID QGVDFKRAVF VPNVSVYNQV GSSTNVGTRV ESMSWQFGLQ 420
  421 RIWESLARGE AKSNSKSDSK GKEEEKSFVF SSLPVAVDWL RDNARQSKQV RFQVLVTGSL 480
  481 HLVGDLLRFI KK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..492] PSI-BLAST 72.69897 Crystal structure of Folylpolyglutamate synthase (TM0166) from Thermotoga maritima at 2.10 A resolution

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • acid-amino acid ligase activity
    		•  4.03401034724886 bayes_pls_golite062009
  • tetrahydrofolylpolyglutamate synthase activity
    		•  3.94486215528378 bayes_pls_golite062009
  • ligase activity
    		•  3.80574681739772 bayes_pls_golite062009
  • catalytic activity
    		•  2.66037860982128 bayes_pls_golite062009
  • dihydrofolate synthase activity
    		•  2.50201834836027 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  1.96801058335544 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.90

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle