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Protein Overview: gi|90109109, gi|...

General Information:
Name(s) found: gi|90109109 [NCBI NR]
gi|90109108 [NCBI NR]
gi|50513864 [NCBI NR]
gi|50513863 [NCBI NR]
gi|50513861 [NCBI NR]
gi|50513860 [NCBI NR]
gi|50513859 [NCBI NR]
gi|50513858 [NCBI NR]
gi|50513857 [NCBI NR]
gi|50513856 [NCBI NR]
gi|50513855 [NCBI NR]
gi|50513854 [NCBI NR]
gi|50513853 [NCBI NR]
gi|50513852 [NCBI NR]
gi|254839174 [NCBI NR]
gi|254839173 [NCBI NR]
gi|254839172 [NCBI NR]
gi|254839171 [NCBI NR]
gi|254839170 [NCBI NR]
gi|254839169 [NCBI NR]
gi|254839168 [NCBI NR]
gi|254839167 [NCBI NR]
gi|162330182 [NCBI NR]
gi|162330181 [NCBI NR]
gi|146387173 [NCBI NR]
Description(s) found:
Found 52 descriptions.
SHOW ALL
  • gi|90109109|pdb|2CDD|B Chain B, Human Hsp90 With 4-(4-(2,3-Dihydro-Benzol(1,4)dioxin-6-Yl)- 5-Methyl-1h-Pyrazol-3-Yl)-6-Ethyl-Benzene-1,3-Diol [NCBI NR]
  • gi|90109108|pdb|2CDD|A Chain A, Human Hsp90 With 4-(4-(2,3-Dihydro-Benzol(1,4)dioxin-6-Yl)- 5-Methyl-1h-Pyrazol-3-Yl)-6-Ethyl-Benzene-1,3-Diol [NCBI NR]
  • gi|50513864|pdb|1UYL|A Chain A, Structure-Activity Relationships In Purine-Based Inhibitor Binding To Hsp90 Isoforms [NCBI NR]
  • gi|50513863|pdb|1UYK|A Chain A, Human Hsp90-Alpha With 8-Benzo[1,3]dioxol-,5-Ylmethyl-9-But Yl-2-Fluoro-9h-Purin-6-Ylamine [NCBI NR]
  • gi|50513861|pdb|1UYH|A Chain A, Human Hsp90-Alpha With 9-Butyl-8-(2,5-Dimethoxy-Benzyl)-2- Fluoro-9h-Purin-6-Ylamine [NCBI NR]
  • gi|50513860|pdb|1UYG|A Chain A, Human Hsp90-Alpha With 8-(2,5-Dimethoxy-Benzyl)-2-Fluoro-9h- Purin-6-Ylamine [NCBI NR]
  • gi|50513859|pdb|1UYF|A Chain A, Human Hsp90-Alpha With 8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)- 2-Fluoro-9-Pent-4-Ylnyl-9h-Purin-6-Ylamine [NCBI NR]
  • gi|50513858|pdb|1UYE|A Chain A, Human Hsp90-Alpha With 8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)- 9-Pent-4-Ylnyl-9h-Purin-6-Ylamine [NCBI NR]
  • gi|50513857|pdb|1UYD|A Chain A, Human Hsp90-Alpha With 9-Butyl-8-(2-Chloro-3,4,5-Trimethoxy- Benzyl)-9h-Purin-6-Ylamine [NCBI NR]
  • gi|50513856|pdb|1UYC|A Chain A, Human Hsp90-Alpha With 9-Butyl-8-(2,5-Dimethoxy-Benzyl)-9h- Purin-6-Ylamine [NCBI NR]
  • gi|50513855|pdb|1UY9|A Chain A, Human Hsp90-Alpha With 8-Benzo[1,3]dioxol-,5-Ylmethyl-9- Butyl-9h-Purin-6-Ylamine [NCBI NR]
  • gi|50513854|pdb|1UY8|A Chain A, Human Hsp90-Alpha With 9-Butyl-8-(3-Trimethoxy-Benzyl)-9h- Purin-6ylamine [NCBI NR]
  • gi|50513853|pdb|1UY7|A Chain A, Human Hsp90-Alpha With 9-Butyl-8-(4-Methoxy-Benzyl)-9h- Purin-6-Ylamine [NCBI NR]
  • gi|50513852|pdb|1UY6|A Chain A, Human Hsp90-Alpha With 9-Butyl-8-(3,4,5-Trimethoxy-Benzyl)- 9h-Purin-6-Ylamine [NCBI NR]
  • gi|254839174|pdb|2WI7|A Chain A, Orally Active 2-Amino Thienopyrimidine Inhibitors Of The Hsp90 Chaperone [NCBI NR]
  • gi|254839173|pdb|2WI6|A Chain A, Orally Active 2-Amino Thienopyrimidine Inhibitors Of The Hsp90 Chaperone [NCBI NR]
  • gi|254839172|pdb|2WI5|A Chain A, Orally Active 2-Amino Thienopyrimidine Inhibitors Of The Hsp90 Chaperone [NCBI NR]
  • gi|254839171|pdb|2WI4|A Chain A, Orally Active 2-Amino Thienopyrimidine Inhibitors Of The Hsp90 Chaperone [NCBI NR]
  • gi|254839170|pdb|2WI3|A Chain A, Orally Active 2-Amino Thienopyrimidine Inhibitors Of The Hsp90 Chaperone [NCBI NR]
  • gi|254839169|pdb|2WI2|B Chain B, Orally Active 2-Amino Thienopyrimidine Inhibitors Of The Hsp90 Chaperone [NCBI NR]
  • gi|254839168|pdb|2WI2|A Chain A, Orally Active 2-Amino Thienopyrimidine Inhibitors Of The Hsp90 Chaperone [NCBI NR]
  • gi|254839167|pdb|2WI1|A Chain A, Orally Active 2-Amino Thienopyrimidine Inhibitors Of The Hsp90 Chaperone [NCBI NR]
  • gi|162330182|pdb|2VCJ|A Chain A, 4,5 Diaryl Isoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents For The Treatment Of Cancer [NCBI NR]
  • gi|162330181|pdb|2VCI|A Chain A, 4,5 Diaryl Isoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents For The Treatment Of Cancer [NCBI NR]
  • gi|146387173|pdb|2UWD|A Chain A, Inhibition Of The Hsp90 Molecular Chaperone In Vitro And In Vivo By Novel, Synthetic, Potent Resorcinylic Pyrazole, Isoxazole Amide Analogs [NCBI NR]
    • Organism: Homo sapiens
    Length: 236 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPEETQTQDQ PMEEEEVETF AFQAEIAQLM SLIINTFYSN KEIFLRELIS NSSDALDKIR  60
   61 YESLTDPSKL DSGKELHINL IPNKQDRTLT IVDTGIGMTK ADLINNLGTI AKSGTKAFME 120
  121 ALQAGADISM IGQFGVGFYS AYLVAEKVTV ITKHNDDEQY AWESSAGGSF TVRTDTGEPM 180
  181 GRGTKVILHL KEDQTEYLEE RRIKEIVKKH SQFIGYPITL FVEKERDKEV SDDEAE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Noble WS, et al. (2009) Manuscript in preparation. gi|112491310 gi|13786858 gi|14277752, gi|... gi|150261449 gi|197725196 gi|219109210, gi... gi|56554577 gi|56966260, gi|... gi|90109109, gi|...

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..236] PSI-BLAST 73.522879 No description for 2fwyA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • kinase activity
    		•  2.91958494250308 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  2.88231613188084 bayes_pls_golite062009
  • protein kinase activity
    		•  2.63552850307457 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  2.57149218947839 bayes_pls_golite062009
  • catalytic activity
    		•  2.10890475146569 bayes_pls_golite062009
  • transferase activity
    		•  1.79719991025192 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.69394711487872 bayes_pls_golite062009
  • signal transducer activity
    		•  1.69394711487872 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.61590772025448 bayes_pls_golite062009
  • DNA binding
    		•  1.34541149261998 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.27928842701525 bayes_pls_golite062009
  • protein histidine kinase activity
    		•  1.14687955873852 bayes_pls_golite062009
  • two-component sensor activity
    		•  1.11862332453882 bayes_pls_golite062009
  • phosphotransferase activity, nitrogenous group as acceptor
    		•  1.02820240565771 bayes_pls_golite062009
  • binding
    		•  0.861888986648473 bayes_pls_golite062009
  • protein binding
    		•  0.858978179630758 bayes_pls_golite062009
  • nitric-oxide synthase regulator activity
    		•  0.851749810145074 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle