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Protein Overview: DRTS2_ARATH

General Information:
Name(s) found: DRTS2_ARATH [Swiss-Prot]
Description(s) found:
Found 10 descriptions.
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  • Bifunctional dihydrofolate reductase-thymidylate synthase 2 OS=Arabidopsis thaliana GN=THY-2 PE=2 SV=2 [Swiss-Prot]
    • Organism: Arabidopsis thaliana
    Length: 565 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: 10-formyltetrahydrofolate biosynthetic process [ISS]
    Molecular Function: thymidylate synthase activity [ISS]
    dihydrofolate reductase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRCLQNSAKT LPLAFKSALL PLSQRWFCKF SPKPSSLTNI FKVSISTMAN TLNGNVIMTS  60
   61 KPQSTYQVVV AATKEMGIGK DGKLPWNLPT DLKFFKDLTL STSDSAKKNA VVMGRKTWES 120
  121 IPKKYRPLSG RLNVVLSRSS GFDIANTENV VTCSSIDSAL DLLAAPPFSL SIEKVFVIGG 180
  181 GDILREALNK PSCEAIHITE IDTSIDCDTF IPTVDTSAYQ PWCSSFPICE NGLRFSFTTH 240
  241 VRVKSSSAGE ASDESDGSKV LQVDWKKFSS VLPKMIFDRH EEYLYLNLVK EIISNGNLKD 300
  301 DRTGTGTLSK FGCQMKFNLR RNFPLLTTKR VFWRGVVEEL LWFISGSTNA KVLQEKGIRI 360
  361 WDGNASRAYL DGIGLTEREE GDLGPVYGFQ WRHFGAKYTD MHADYTGQGF DQLLDVINKI 420
  421 KNNPDDRRII MSAWNPSDLK LMALPPCHMF AQFYVANGEL SCQMYQRSAD MGLGVPFNIA 480
  481 SYSLLTCILA HVCDLVPGDF IHVIGDAHVY KNHVRPLQEQ LENPPKPFPV LKINPEKKDI 540
  541 DSFVADDFEL IGYDPHKKID MKMAV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..565] PSI-BLAST 173.0 Crystal structure of DHFR-TS from Cryptosporidium hominis

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • thymidylate synthase activity
    		•  6.6988475347328 bayes_pls_golite062009
  • 5,10-methylenetetrahydrofolate-dependent methyltransferase activity
    		•  6.29181090719132 bayes_pls_golite062009
  • dihydrofolic acid binding
    		•  5.17709559620199 bayes_pls_golite062009
  • dihydrofolate reductase activity
    		•  4.66343252900911 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
    		•  4.14137539326183 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH group of donors
    		•  3.88025481634404 bayes_pls_golite062009
  • binding
    		•  1.89072001556053 bayes_pls_golite062009
  • catalytic activity
    		•  1.73427871128495 bayes_pls_golite062009
  • transferase activity
    		•  1.72626940963556 bayes_pls_golite062009
  • methyltransferase activity
    		•  0.927096828883487 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  0.91282507161672 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.63757996555211 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.66

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle