YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|3643245, gi\|6...
Organism:	Mus musculus
Length:	289 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|3643245, gi|6....

Description	E-value	Query Range	Subject Range
gi\|148226212, gi... - gi\|38014417\|gb\|AAH60459.1\| MGC68566 protein [Xenopus laevis], gi\|148226212\|ref\|NP_001083469.1\| hypot...	398.0	[0..1]	[289..1]
GNPI1_MOUSE, GNP... - Glucosamine-6-phosphate isomerase - Mus musculus (Mouse), Glucosamine-6-phosphate isomerase 1 OS=Mus...	396.0	[0..1]	[289..1]
gi\|197246475, gi... - gi\|201861364\|ref\|NP_001128467.1\| glucosamine-6-phosphate deaminase 1 [Rattus norvegicus], gi\|1972464...	395.0	[0..1]	[289..1]
ENSOCUP000000145... - pep:novel chromosome:oryCun2:3:24036089:24042485:-1 gene:ENSOCUG00000016963 transcript:ENSOCUT000000... GNPI1_BOVIN - Glucosamine-6-phosphate isomerase 1 OS=Bos taurus GN=GNPDA1 PE=2 SV=1	393.0	[0..1]	[289..1]
gi\|114602426 - gi\|114602426\|ref\|XP_001139968.1\| PREDICTED: similar to KIAA0060 [Pan troglodytes]	392.0	[0..1]	[289..73]
gi\|40789072 - gi\|40789072\|dbj\|BAA06544.2\| KIAA0060 [Homo sapiens]	392.0	[0..1]	[289..29]
GNPI1_MESAU - Glucosamine-6-phosphate isomerase 1 OS=Mesocricetus auratus GN=GNPDA1 PE=2 SV=1	392.0	[0..1]	[289..1]
GNPI1_PONAB - Glucosamine-6-phosphate isomerase 1 OS=Pongo abelii GN=GNPDA1 PE=2 SV=1 GNPI_PONPY - Glucosamine-6-phosphate isomerase - Pongo pygmaeus (Orangutan)	391.0	[0..1]	[289..1]

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Predicted Domain #1

Region A:
Residues: [1-289]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKLIILEHYS QASEWAAKYI RNRIIQFNPG PDKYFTLGLP TGSTPLGCYQ KLIEYYKNGD  60
   61 LSFQYVKTFN MDEYVGLPRD HPESYHFFMW DNFFKHIDIH PENTHILDGN AADLQAECDA 120
  121 FEEKIQAAGG IELFVGGIGP DGHIAFNEPG SSLVSRTRVK TLAMDTILAN GRFFDGDLAK 180
  181 VPTMALTVGV GTVMDAKEVM ILITGAHKAF ALYKAIEEGV NHMWTVSAFQ QHPRTVFVCD 240
  241 EDATLELKVK TVKYFKGLML VHNKLVDPLY SIKEKEIQKS QSAKKPYSD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	110.0
Match:	1ne7A
Description:	HUMAN GLUCOSAMINE-6-PHOSPHATE DEAMINASE ISOMERASE AT 1.75 A RESOLUTION COMPLEXED WITH N-ACETYL-GLUCOSAMINE-6-PHOSPHATE AND 2-DEOXY-2-AMINO-GLUCITOL-6-PHOSPHATE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
glucosamine-6-phosphate deaminase activity	4.20201419087614	bayes_pls_golite062009
intramolecular oxidoreductase activity	2.15381323621148	bayes_pls_golite062009
intramolecular oxidoreductase activity, interconverting aldoses and ketoses	1.65800801564277	bayes_pls_golite062009
catalytic activity	1.31732715713197	bayes_pls_golite062009
ribose-5-phosphate isomerase activity	1.21538742769205	bayes_pls_golite062009
nucleic acid binding	1.15193795385115	bayes_pls_golite062009
binding	0.790197816513984	bayes_pls_golite062009
transcription regulator activity	0.527142798518238	bayes_pls_golite062009
6-phosphogluconolactonase activity	0.480819049634739	bayes_pls_golite062009
DNA binding	0.465566131334457	bayes_pls_golite062009
isomerase activity	0.102415560220489	bayes_pls_golite062009
protein binding	0.0458232930850621	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: