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View Structure Prediction Details

Protein: K1043_MOUSE, TTC...
Organism: Mus musculus
Length: 1691 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for K1043_MOUSE, TTC....

Description E-value Query
Range
Subject
Range
gi|109496198 - gi|109496198|ref|XP_222260.4| PREDICTED: similar to TPR repeat-containing protein KIAA1043 [Rattus n...
1271.0 [0..1] [1691..879]
gi|58257739 - gi|58257739|dbj|BAA82995.3| KIAA1043 protein [Homo sapiens]
1267.0 [0..1] [1691..411]
gi|114685618 - gi|114685618|ref|XP_001172489.1| PREDICTED: tetratricopeptide repeat domain 28 [Pan troglodytes]
1264.0 [0..1] [1691..766]
gi|109093703 - gi|109093703|ref|XP_001108189.1| PREDICTED: hypothetical protein LOC23331, partial [Macaca mulatta]
1263.0 [0..1] [1691..639]
gi|50756541 - gi|50756541|ref|XP_415204.1| PREDICTED: similar to TPR repeat containing protein KIAA1043 [Gallus ga...
1248.0 [0..1] [1691..888]
gi|73994867 - gi|73994867|ref|XP_543463.2| PREDICTED: similar to TPR repeat containing protein KIAA1043 isoform 1 ...
1219.0 [0..1] [1691..766]
gi|33438287 - gi|33438287|dbj|BAC65709.2| mKIAA1043 protein [Mus musculus]
1044.0 [0..128] [1691..1]
gi|47228495 - gi|47228495|emb|CAG05315.1| unnamed protein product [Tetraodon nigroviridis]
953.0 [0..2] [1691..538]

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Predicted Domain #1
Region A:
Residues: [1-418]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVQKYDKALG YHTQELEVYQ ELSDLPGECR AHGHLAAVYM ALGKYTMAFK CYQEQLELGR  60
   61 KLKEPSLEAQ VYGNMGITKM NMNVMEDAIG YFEQQLAMLQ QLSGNESVLD RGRAYGNLGD 120
  121 CYEALGDYEE AIKYYEQYLS VAQSLNRMQD QAKAYRGLGN GHRATGSLQQ ALVCFEKRLV 180
  181 VAHELGEASN KAQAYGELGS LHSQLGNYEQ AISCLERQLN IARDMKDRAL ESDAACGLGG 240
  241 VYQQMGEYDT ALQYHQLDLQ IAEETDNPTC QGRAYGNLGL TYESLGTFER AVVYQEQHLS 300
  301 IAAQMNDLVA KTVSYSSLGR THHALQNYSQ AVMYLQEGLR LAEQLGRRED EAKIRHGLGL 360
  361 SLWASGNLEE AQHQLYRASA LFETIRHEAQ LSTDYKLSLF DLQTSSYQAL QRVLVSLG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 78.39794
Match: 1w3bA
Description: The superhelical TPR domain of O-linked GlcNAc transferase reveals structural similarities to importin alpha.
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [419-675]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HHDEALAVAE RGRTRAFADL LVERQTGQQD SDPYSPITID QILEMVNAQR GLVLYYSLAA  60
   61 GYLYSWLLAP GAGILKFHEH YLGDNSVESS SDFQAGSSAA LPVATNSTLE QHIASVREAL 120
  121 GVESYYSRAC ASSETESEAG DIMEQQLEEM NKQLNSVTDP TGFLRMVRHN NLLHRSCQSM 180
  181 TSLFSGTVSP SKDGTSSLPR RQNSLAKPPL RALYDLLIAP MEGGLMHSSG PVGRHRQLVL 240
  241 VLEGELYFVP FALLKGS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.0
Match: 1ya0A
Description: Crystal structure of the N-terminal domain of human SMG7
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [676-788]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ASNEYLYERF TLIAVPAVRS LGPHSKCHLR KTPPTYSSST TMAAVIGNPK LPSAVMDRWL  60
   61 WGPMPSAEEE AFMVSELLGC QPLVGSMATK ERVMSALTQA ECVHFATHVS WKL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [789-950]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SALVLTPNTE GNPAGSKSSF GHPYTIPESL RVQDDASDVE SISDCPPLRE LLLTAADLLD  60
   61 LRLSVKLVVL SSSQEANGRV TADGLVALTR AFLAAGAQCV LVALWPVPVA ASKMFVHAFY 120
  121 SSLLNGLKAS ASLGEAMKVV QSSKAFSHPS NWAGFTLIGS DV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [951-1062]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KLNSPSSLIG QALTEILQHP ERARDALRVL LHLVEKSLQR IQNGQRNAMY TSQQSVENKV  60
   61 GGIPGWQALL TAVGFRLDPA ASGLPAAVFF PTSDPGDRLQ QCSSTLQALL GL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [1063-1691]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PNPALQALCK LITASETGEQ LISRAVKNMV GMLHQVLVQL QACEKEQDFA SAPIPVSLSV  60
   61 QLWRLPGCHE FLAALGFDLC EVGQEEVILK TGKQASRRTT HFALQSLLSL FDSTELPKRL 120
  121 SLDSSSSLES LASAQSVSNA LPLGYQHPPF SPTGADSIAS DAISVYSLSS IASSMSFVSK 180
  181 PEGGLEGGGP RGRQDYDRSK STHPQRATLP RRQTSPQARR GASKEEEEYE GFSIISMEPL 240
  241 ATYQGEGKTR FSPDPKQPCV KAPGGVRLSV SSKGSVSTPN SPVKMTLIPS PNSPFQKVGK 300
  301 LASSDTGESD QSSTETDSTV KSQEESTPKL DPQELAQRIL EETKSHLLAV ERLQRSGGPA 360
  361 GPDREDSVVA PSSTTVFRAS ETSAFSKPIL SHQRSQLSPL TVKPQPPARS SSLPKVSSPA 420
  421 TSEVSGKDGL SPPGSSHPSP GRDTPVSPAD PPLFRLKYPS SPYSAHISKS PRNTSPACSA 480
  481 PSPALSYSSA GSARSSPADA PDEKVQAVHS LKMLWQSTPQ PPRGPRKTCR GAPGTLTSKR 540
  541 DVLSLLNLSP RHGKEEGGAD RLELKELSVQ RHDEVPPKVP TNGHWCTDTA TLTTAGGRST 600
  601 TAAPRPLRLP LANGYKFLSP GRLFPSSKC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.221849
Match: 1y0fA
Description: No description for 1y0fA was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle