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View Structure Prediction Details

Protein: ssp4-PB
Organism: Drosophila melanogaster
Length: 1540 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ssp4-PB.

Description E-value Query
Range
Subject
Range
ssp4-PA - The gene short spindle 4 is referred to in FlyBase by the symbol Dmel\ssp4 (CG33130, FBgn0022085). I...
828.0 [0..1] [1540..1]

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Predicted Domain #1
Region A:
Residues: [1-301]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDVETQEIRQ ARQRASVKWL LSKAFNNRVP DNLKEPFYRD HENQERLKPQ IIVELGNATL  60
   61 YCQTLANLYS DPNYQSMNHW SIIQTLARKG VPVAESADMP ITETVLIQTN PLRINAHMSV 120
  121 IESLMVLYAK EISSGDRVMA AIRRISGNNY QAPTGQSYEQ ALLGWISHAC AALKKRIIKE 180
  181 VDAGLPDDNG SRLQTPDIPP VRDFQDLCDG ICLALLISYY CPKVVPWTSV RINYLPAVED 240
  241 SIHNILLVCN FSQKHLPYTV MHMTPEDVTY MRGSMKLNLV VLLTDLFNLF EIHPAKCVCY 300
  301 P

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.11
Match: 1sh5A
Description: Crystal structure of actin-binding domain of mouse plectin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cytoskeletal protein binding 6.0562477479739 bayes_pls_golite062009
microtubule binding 5.63808442303747 bayes_pls_golite062009
tubulin binding 5.63161872515663 bayes_pls_golite062009
actin binding 5.4843525466095 bayes_pls_golite062009
actin filament binding 3.58546515893973 bayes_pls_golite062009
binding 2.58893177478913 bayes_pls_golite062009
protein binding 2.38389820189848 bayes_pls_golite062009
microtubule plus-end binding 2.34204492212228 bayes_pls_golite062009
structural constituent of cytoskeleton 2.33067686982903 bayes_pls_golite062009
dynein binding 0.282231591450947 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [302-1054]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GMDGQVPHSN SFGGGLNRRS TPPNEYQTVQ SNNFDGNHAE AFVVHKSRGI TTLASMHSQQ  60
   61 QQQLHQQQQH QQQYHQQPLQ QHPSQSQLQI QQQEPLVPAR LRQAKEKTNV ESKADERGDF 120
  121 VAAGRPSNWE QSRRPSFAGR RSRRNSSSED SQLTIENFGG SQDQLNTLGR YERDRERKLS 180
  181 NTSVGSYPVE PAVAVRSSIA DARGTLQLGY DTDSGSEKQD RETEKYSMRR QVSVDNVPTV 240
  241 SSHNLSNAGS PLPVARHKQH SSDKDYSSNS GMTPDAYNDS RSTSGYDPES TPVRKSSTSS 300
  301 MPASPAAWQL DVGDDDMRSL ENASKLSTIR MKLEEKRRRI EQDKRKIEMA LLRHQEKEDL 360
  361 ESCPDVMKWE TMSNESKRTP DMDPVDLDKY QAYNAPVSAY SSRPPSRDPY QQQLHHQQQQ 420
  421 PMPMPQPMQY VNEHGQYMSP PQPAHYMPQQ AQQPQSIYSD NGAAYNHSNH SPYGGTPQYR 480
  481 SSVVYDDYGQ PTNHFYLHES SPQPQAHQHP QRRTWAHSAA AAAYEQQQQI QPSLVDVNAW 540
  541 QTQQHQKQKQ TWMNRPPSSA GAPSPGSFML HQNGGGGGGG GGGGELQHLF QVQASPQHGQ 600
  601 RQVSGSNGVQ RQQSLTNLRD NRSPKAPQNM GMPMGMPMQQ EDMMAPQSIC FIGDEEDVDE 660
  661 LERNIIESMQ STHISDFVHQ QQQQHQHQQQ LQQQQRLQGH SGRGSSSEDY DSGEMISNKL 720
  721 NITSGNLTYR IPSPSRPSIQ ANSFQDPRAM AAA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.0
Match: 1y0fA
Description: No description for 1y0fA was found.

Predicted Domain #3
Region A:
Residues: [1055-1127]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGGEDQPPEK GFYISFDDEQ PKRPKPPLRA KRSPKKESPP GSRDSVDNQA TLKRESLSHL  60
   61 HNNNNIGFGN DDV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [1128-1457]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSKPVTRHSI HGLNNSNSVK SPGNATYNKY TDEPPIQLRQ LAVSGAMSPT SNERHHLDDV  60
   61 SNQSPQQTQQ PMSPTRLQQS SNNAEAAKNK ALVIGADSTN LDPESVDEME RRKEKIMLLS 120
  121 LQRRQQQEEA KARKEIEASQ KREKEREKEE ERARKKEEQM ARRAAILEQH RLKKAIEEAE 180
  181 REGKTLDRPD LHVKLQSHSS TSTTPRLRQQ RTTRPRPKTI HVDDASVDIS EASSISSRGK 240
  241 KGSSSNLTDS GLGRATPPRR APSPGMGMGA SGPKLYKQPA AKSNRGIILN AVEYCVFPGV 300
  301 VNREAKQKVL EKIARSEAKH FLVLFRDAGC 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.39794
Match: 1i84S
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [1458-1540]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QFRALYSYQP ETDQVTKLYG TGPSQVEEVM FDKFFKYNSG GKCFSQVHTK HLTVTIDAFT  60
   61 IHNSLWQGKR VQLPSKKDMA LVI

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.54
Match: 1ugjA
Description: Solution structure of a murine hypothetical protein from RIKEN cDNA 2310057J16
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle