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View Structure Prediction Details

Protein: ssp4-PC
Organism: Drosophila melanogaster
Length: 1630 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ssp4-PC.

Description E-value Query
Range
Subject
Range
ssp4-PB - The gene short spindle 4 is referred to in FlyBase by the symbol Dmel\ssp4 (CG33130, FBgn0022085). I...
784.0 [0..1] [1630..1]

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Predicted Domain #1
Region A:
Residues: [1-297]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDVETQEIRQ ARQRASVKWL LSKAFNNRVP DNLKEPFYRD HENQERLKPQ IIVELGNATL  60
   61 YCQTLANLYS DPNYQSMNHW SIIQTLARKG VPVAESADMP ITETVLIQTN PLRINAHMSV 120
  121 IESLMVLYAK EISSGDRVMA AIRRISGNNY QAPTGQSYEQ ALLGWISHAC AALKKRIIKE 180
  181 VDAGLPDDNG SRLQTPDIPP VRDFQDLCDG ICLALLISYY CPKVVPWTSV RINYLPAVED 240
  241 SIHNILLVCN FSQKHLPYTV MHMTPEDVTY MRGSMKLNLV VLLTDLFNLF EIHPAKC

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.2
Match: 1sh5A
Description: Crystal structure of actin-binding domain of mouse plectin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cytoskeletal protein binding 6.0562477479739 bayes_pls_golite062009
microtubule binding 5.63808442303747 bayes_pls_golite062009
tubulin binding 5.63161872515663 bayes_pls_golite062009
actin binding 5.4843525466095 bayes_pls_golite062009
actin filament binding 3.58546515893973 bayes_pls_golite062009
binding 2.58893177478913 bayes_pls_golite062009
protein binding 2.38389820189848 bayes_pls_golite062009
microtubule plus-end binding 2.34204492212228 bayes_pls_golite062009
structural constituent of cytoskeleton 2.33067686982903 bayes_pls_golite062009
dynein binding 0.282231591450947 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [298-392]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VCYPGMDGQV PHSNSFGGGL NRRSTPPNEY QTVQSNNFDG NHAEAFVVHK SRGITTLASM  60
   61 HSQQQQQLHQ QQQHQQQYHQ QPLQQHPSQS QLQIQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [393-977]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QQEPLVPARL RQAKEKTNVE SKADERGRRS RRNSSSEDSQ LTIENFGGSQ DQLNTLGRYE  60
   61 RDRERKLSNT SVGSYPVEPA VAVRSSIADA RGTLQLGYDT DSGSEKQDRE TEKYSMRRQV 120
  121 SVDNVPTVSS HNLSNAGSPL PVARHKQHSS DKDYSSNSGM TPDAYNDSRS TSGYDPESTP 180
  181 VRKSSTSSMP ASPAAWQLDV GDDDMRSLEN ASKLSTIRMK LEEKRRRIEQ DKRKIEMALL 240
  241 RHQEKEDLES CPDVMKWETM SNESKRTPDM DPVDLDKYQQ SIAIMNMNLQ DIQQDIHRLA 300
  301 TQQSQMQAQH LQAQQLMQAQ QIANMLNQAY NAPVSAYSSR PPSRDPYQQQ LHHQQQQPMP 360
  361 MPQPMQYVNE HGQYMSPPQP AHYMPQQAQQ PQSIYSDNGA AYNHSNHSPY GGTPQYRSSV 420
  421 VYDDYGQPTN HFYLHESSPQ PQAHQHPQRR TWAHSAAAAA YEQQQQIQPS LVDVNAWQTQ 480
  481 QHQKQKQTWM NRPPSSAGAP SPGSFMLHQN GGGGGGGGGG GELQHLFQVQ ASPQHGQRQV 540
  541 SGSNGVQRQQ SLTNLRDNRS PKAPQNMGMP MGMPMQQEDM MAPQS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.221849
Match: 1y0fA
Description: No description for 1y0fA was found.

Predicted Domain #4
Region A:
Residues: [978-1111]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ICFIGDEEDV DELERNIIES MQSTHISDFV HQQQQQHQHQ QQLQQQQRLQ GHSGRGSSSE  60
   61 DYDSGEMISN KLNITSGNLT YRIPSPSRPS IQANSFQDPR AMAAASGGED QPPEKGFYIS 120
  121 FDDEQPKRPK PPLR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [1112-1236]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AKRSPKKESP PGSRDSVDNQ ATLKRESLSH LHNNNNIGFG NDDVNSKPVT RHSIHGLNNS  60
   61 NSVKSPGNAT YNKYTDEPPI QLRQLAVSGA MSPTSNERHH LDDVSNQSPQ QTQQPMSPTR 120
  121 LQQSS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.522879
Match: 2tmaA
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [1237-1554]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NNAEAAKNKA LVIGADSTNL DPESVDEMER RKEKIMLLSL QRRQQQEEAK ARKEIEASQK  60
   61 REKEREKEEE RARKKEEQMA RRAAILEQHR LKKAIEEAER EGKTLDRPDL HVKLQSHSST 120
  121 STTPRLRQQR TTRPRPKTIH VDDASVDISE ASSISSRGKK GSSSNLTGYG QLSSNSMKRD 180
  181 YYRGSQDSLT VKESPDDYPS TSSTPIGRRG SYKTSREPAG VERGRTLSRI SVAKGSTLNF 240
  241 RGRKSNSLMN LCGPKLYKQP AAKSNRGIIL NAVEYCVFPG VVNREAKQKV LEKIARSEAK 300
  301 HFLVLFRDAG CQFRALYS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.30103
Match: 1i84S
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [1555-1630]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YQPETDQVTK LYGTGPSQVE EVMFDKFFKY NSGGKCFSQV HTKHLTVTID AFTIHNSLWQ  60
   61 GKRVQLPSKK DMALVI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 56.69897
Match: 1ugjA
Description: Solution structure of a murine hypothetical protein from RIKEN cDNA 2310057J16
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle