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Protein Overview: ssp4-PC

General Information:
Name(s) found: ssp4-PC / FBpp0086106 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene short spindle 4 is referred to in FlyBase by the symbol Dmel\ssp4 (CG33130, FBgn0022085). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:13406523..13422942. It has the cytological map location 54C1-54C3. Based on sequence similarity, it is predicted to have molecular function</span>: microtubule binding. There is experimental evidence that it is involved in the biological process</span>: mitotic spindle elongation; microtubule severing. 8 alleles are reported. No phenotypic data is available. It has 8 annotated transcripts and 8 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1630 amino acids

    Gene Ontology:
    Cellular Component: spindle [IDA]
    Biological Process: mitotic spindle elongation [IMP]
    microtubule severing [IMP]
    Molecular Function: microtubule binding [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDVETQEIRQ ARQRASVKWL LSKAFNNRVP DNLKEPFYRD HENQERLKPQ IIVELGNATL  60
   61 YCQTLANLYS DPNYQSMNHW SIIQTLARKG VPVAESADMP ITETVLIQTN PLRINAHMSV 120
  121 IESLMVLYAK EISSGDRVMA AIRRISGNNY QAPTGQSYEQ ALLGWISHAC AALKKRIIKE 180
  181 VDAGLPDDNG SRLQTPDIPP VRDFQDLCDG ICLALLISYY CPKVVPWTSV RINYLPAVED 240
  241 SIHNILLVCN FSQKHLPYTV MHMTPEDVTY MRGSMKLNLV VLLTDLFNLF EIHPAKCVCY 300
  301 PGMDGQVPHS NSFGGGLNRR STPPNEYQTV QSNNFDGNHA EAFVVHKSRG ITTLASMHSQ 360
  361 QQQQLHQQQQ HQQQYHQQPL QQHPSQSQLQ IQQQEPLVPA RLRQAKEKTN VESKADERGR 420
  421 RSRRNSSSED SQLTIENFGG SQDQLNTLGR YERDRERKLS NTSVGSYPVE PAVAVRSSIA 480
  481 DARGTLQLGY DTDSGSEKQD RETEKYSMRR QVSVDNVPTV SSHNLSNAGS PLPVARHKQH 540
  541 SSDKDYSSNS GMTPDAYNDS RSTSGYDPES TPVRKSSTSS MPASPAAWQL DVGDDDMRSL 600
  601 ENASKLSTIR MKLEEKRRRI EQDKRKIEMA LLRHQEKEDL ESCPDVMKWE TMSNESKRTP 660
  661 DMDPVDLDKY QQSIAIMNMN LQDIQQDIHR LATQQSQMQA QHLQAQQLMQ AQQIANMLNQ 720
  721 AYNAPVSAYS SRPPSRDPYQ QQLHHQQQQP MPMPQPMQYV NEHGQYMSPP QPAHYMPQQA 780
  781 QQPQSIYSDN GAAYNHSNHS PYGGTPQYRS SVVYDDYGQP TNHFYLHESS PQPQAHQHPQ 840
  841 RRTWAHSAAA AAYEQQQQIQ PSLVDVNAWQ TQQHQKQKQT WMNRPPSSAG APSPGSFMLH 900
  901 QNGGGGGGGG GGGELQHLFQ VQASPQHGQR QVSGSNGVQR QQSLTNLRDN RSPKAPQNMG 960
  961 MPMGMPMQQE DMMAPQSICF IGDEEDVDEL ERNIIESMQS THISDFVHQQ QQQHQHQQQL1020
 1021 QQQQRLQGHS GRGSSSEDYD SGEMISNKLN ITSGNLTYRI PSPSRPSIQA NSFQDPRAMA1080
 1081 AASGGEDQPP EKGFYISFDD EQPKRPKPPL RAKRSPKKES PPGSRDSVDN QATLKRESLS1140
 1141 HLHNNNNIGF GNDDVNSKPV TRHSIHGLNN SNSVKSPGNA TYNKYTDEPP IQLRQLAVSG1200
 1201 AMSPTSNERH HLDDVSNQSP QQTQQPMSPT RLQQSSNNAE AAKNKALVIG ADSTNLDPES1260
 1261 VDEMERRKEK IMLLSLQRRQ QQEEAKARKE IEASQKREKE REKEEERARK KEEQMARRAA1320
 1321 ILEQHRLKKA IEEAEREGKT LDRPDLHVKL QSHSSTSTTP RLRQQRTTRP RPKTIHVDDA1380
 1381 SVDISEASSI SSRGKKGSSS NLTGYGQLSS NSMKRDYYRG SQDSLTVKES PDDYPSTSST1440
 1441 PIGRRGSYKT SREPAGVERG RTLSRISVAK GSTLNFRGRK SNSLMNLCGP KLYKQPAAKS1500
 1501 NRGIILNAVE YCVFPGVVNR EAKQKVLEKI ARSEAKHFLV LFRDAGCQFR ALYSYQPETD1560
 1561 QVTKLYGTGP SQVEEVMFDK FFKYNSGGKC FSQVHTKHLT VTIDAFTIHN SLWQGKRVQL1620
 1621 PSKKDMALVI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..297] FFAS03 2.2 Crystal structure of actin-binding domain of mouse plectin
    2 View Details [298..392] deduced N/A No confident structure predictions are available.
    3 View Details [393..977] PSI-BLAST 3.221849 No description for 1y0fA was found.
    4 View Details [978..1111] deduced N/A No confident structure predictions are available.
    5 View Details [1112..1236] PSI-BLAST 6.522879 Tropomyosin
    6 View Details [1237..1554] PSI-BLAST 22.30103 Heavy meromyosin subfragment
    7 View Details [1555..1630] PSI-BLAST 56.69897 Solution structure of a murine hypothetical protein from RIKEN cDNA 2310057J16

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • cytoskeletal protein binding
    		•  6.0562477479739 bayes_pls_golite062009
  • microtubule binding
    		•  5.63808442303747 bayes_pls_golite062009
  • tubulin binding
    		•  5.63161872515663 bayes_pls_golite062009
  • actin binding
    		•  5.4843525466095 bayes_pls_golite062009
  • actin filament binding
    		•  3.58546515893973 bayes_pls_golite062009
  • binding
    		•  2.58893177478913 bayes_pls_golite062009
  • protein binding
    		•  2.38389820189848 bayes_pls_golite062009
  • microtubule plus-end binding
    		•  2.34204492212228 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  2.33067686982903 bayes_pls_golite062009
  • dynein binding
    		•  0.282231591450947 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle