YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|42542392, gi\|...
Organism:	Homo sapiens
Length:	1054 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|42542392, gi|....

Description	E-value	Query Range	Subject Range
CEBPZ - CCAAT/enhancer binding protein (C/EBP), zeta	0.0	[1..1054]	[1..1054]
gi\|114576958 - gi\|114576958\|ref\|XP_001166712.1\| PREDICTED: CCAAT/enhancer binding protein zeta isoform 1 [Pan trogl...	0.0	[1..1054]	[1..1054]
CEBPZ_MOUSE - CCAAT/enhancer-binding protein zeta OS=Mus musculus GN=Cebpz PE=1 SV=2	0.0	[1..1054]	[1..1052]
gi\|109477834 - gi\|109477834\|ref\|XP_343003.3\| PREDICTED: similar to CCAAT/enhancer binding protein zeta [Rattus norv...	0.0	[1..1054]	[1..1045]
gi\|73980158 - gi\|73980158\|ref\|XP_540150.2\| PREDICTED: similar to CCAAT/enhancer binding protein zeta isoform 1 [Ca...	0.0	[1..1054]	[1..1057]

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Predicted Domain #1

Region A:
Residues: [1-112]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAVKEPLEF HAKRPWRPEE AVEDPDEEDE DNTSEAENGF SLEEVLRLGG TKQDYLMLAT  60
   61 LDENEEVIDG GKKGAIDDLQ QGELEAFIQN LNLAKYTKAS LVEEDEPAEK EN

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [113-217]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSKKEVKIPK INNKNTAESQ RTSVNKVKNK NRPEPHSDEN GSTTPKVKKD KQNIFEFFER  60
   61 QTLLLRPGGK WYDLEYSNEY SLKPQPQDVV SKYKTLAQKL YQHEI

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.06
Match:	1wa5B
Description:	Crystal structure of the exportin Cse1p complexed with its cargo ( Kap60p) and RanGTP
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [218-761]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NLFKSKTNSQ KGASSTWMKA IVSSGTLGDR MAAMILLIQD DAVHTLQFVE TLVNLVKKKG  60
   61 SKQQCLMALD TFKELLITDL LPDNRKLRIF SQRPFDKLEQ LSSGNKDSRD RRLILWYFEH 120
  121 QLKHLVAEFV QVLETLSHDT LVTTKTRALT VAHELLCNKP EEEKALLVQV VNKLGDPQNR 180
  181 IATKASHLLE TLLCKHPNMK GVVSGEVERL LFRSNISSKA QYYAICFLNQ MALSHEESEL 240
  241 ANKLITVYFC FFRTCVKKKD VESKMLSALL TGVNRAYPYS QTGDDKVREQ IDTLFKVLHI 300
  301 VNFNTSVQAL MLLFQVMNSQ QTISDRYYTA LYRKMLDPGL MTCSKQAMFL NLVYKSLKAD 360
  361 IVLRRVKAFV KRLLQVTCQQ MPPFICGALY LVSEILKAKP GLRSQLDDHP ESDDEENFID 420
  421 ANDDEDMEKF TDADKETEIV KKLETEETVP ETDVETKKPE VASWVHFDNL KGGKQLNKYD 480
  481 PFSRNPLFCG AENTSLWELK KLSVHFHPSV ALFAKTILQG NYIQYSGDPL QDFTLMRFLD 540
  541 RFVY

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.14
Match:	1gw5B
Description:	Adaptin beta subunit N-terminal fragment
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	3.4840129457355	bayes_pls_golite062009
nucleic acid binding	2.27889073911459	bayes_pls_golite062009
protein binding	2.22592441892741	bayes_pls_golite062009
transcription regulator activity	2.19067997822967	bayes_pls_golite062009
DNA binding	1.71679738414596	bayes_pls_golite062009
transcription factor activity	1.01026749293758	bayes_pls_golite062009
RNA binding	0.243875756041061	bayes_pls_golite062009
transcription activator activity	0.142253868848261	bayes_pls_golite062009
transcription factor binding	8.79739237675814E-4	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [762-825]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RNPKPHKGKE NTDSVVMQPK RKHFIKDIRH LPVNSKEFLA KEESQIPVDE VFFHRYYKKV  60
   61 AVKE

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5

Region A:
Residues: [826-975]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KQKRDADEES IEDVDDEEFE ELIDTFEDDN CFSSGKDDMD FAGNVKKRTK GAKDNTLDED  60
   61 SEGSDDELGN LDDDEVSLGS MDDEEFAEVD EDGGTFMDVL DDESESVPEL EVHSKVSTKK 120
  121 SKRKGTDDFD FAGSFQGPRK KKRNLNDSSL

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6

Region A:
Residues: [976-1054]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FVSAEEFGHL LDENMGSKFD NIGMNAMANK DNASLKQLRW EAERDDWLHN RDAKSIIKKK  60
   61 KHFKKKRIKT TQKTKKQRK

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: