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View Structure Prediction Details

Protein: gi|119628575, gi...
Organism: Homo sapiens
Length: 807 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|119628575, gi....

Description E-value Query
Range
Subject
Range
gi|22759956, gi|... - gi|38201700|ref|NP_937984.1| telomerase reverse transcriptase isoform 4 [Homo sapiens], gi|22759956|...
0.0 [1..807] [1..795]
gi|3023055 - gi|3023055|gb|AAC40212.1| telomerase catalytic subunit [synthetic construct]
0.0 [1..763] [1..763]
gi|114598857 - gi|114598857|ref|XP_001141663.1| PREDICTED: telomerase reverse transcriptase isoform 2 [Pan troglody...
0.0 [1..755] [1..755]
gi|109076635 - gi|109076635|ref|XP_001096904.1| PREDICTED: similar to telomerase reverse transcriptase isoform 1 is...
0.0 [1..763] [1..763]

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Predicted Domain #1
Region A:
Residues: [1-214]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPRAPRCRAV RSLLRSHYRE VLPLATFVRR LGPQGWRLVQ RGDPAAFRAL VAQCLVCVPW  60
   61 DARPPPAAPS FRQVSCLKEL VARVLQRLCE RGAKNVLAFG FALLDGARGG PPEAFTTSVR 120
  121 SYLPNTVTDA LRGSGAWGLL LRRVGDDVLV HLLARCALFV LVAPSCAYQV CGPPLYQLGA 180
  181 ATQARPPPHA SGPRRRLGCE RAWNHSVREA GVPL

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.02
Match: 2b2aA
Description: Crystal Structure of the TEN domain of the Telomerase Reverse Transcriptase
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [215-455]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GLPAPGARRR GGSASRSLPL PKRPRRGAAP EPERTPVGQG SWAHPGRTRG PSDRGFCVVS  60
   61 PARPAEEATS LEGALSGTRH SHPSVGRQHH AGPPSTSRPP RPWDTPCPPV YAETKHFLYS 120
  121 SGDKEQLRPS FLLSSLRPSL TGARRLVETI FLGSRPWMPG TPRRLPRLPQ RYWQMRPLFL 180
  181 ELLGNHAQCP YGVLLKTHCP LRAAVTPAAG VCAREKPQGS VAAPEEEDTD PRRLVQLLRQ 240
  241 H

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [456-567]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSPWQVYGFV RACLRRLVPP GLWGSRHNER RFLRNTKKFI SLGKHAKLSL QELTWKMSVR  60
   61 DCAWLRRSPG VGCVPAAEHR LREEILAKFL HWLMSVYVVE LLRSFFYVTE TT

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [568-640]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FQKNRLFFYR KSVWSKLQSI GIRQHLKRVQ LRELSEAEVR QHREARPALL TSRLRFIPKP  60
   61 DGLRPIVNMD YVV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [641-702]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GARTFRREKR AERLTSRVKA LFSVLNYERA RRPGLLGASV LGLDDIHRAW RTFVLRVRAQ  60
   61 DP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.814 N/A N/A a.48.3 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70

Predicted Domain #6
Region A:
Residues: [703-807]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPELYFVKVD VTGAYDTIPQ DRLTEVIASI IKPQNTYCVR RYAVVQKAAH GHVRKAFKSH  60
   61 VLRPVPGDPA GLHPLHAALQ PVLRRHGEQA VCGDSAGRAA PAFGG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle