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View Structure Prediction Details

Protein: gi|33598968, gi|...
Organism: Homo sapiens
Length: 1349 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|33598968, gi|....

Description E-value Query
Range		 Subject
Range
gi|17225574 - gi|17225574|gb|AAL37480.1|AF330045_1 LIM domain only 7 [Homo sapiens]
 0.0 [1..1349] [1..1349]
gi|114650089 - gi|114650089|ref|XP_001139492.1| PREDICTED: LIM domain only 7 isoform 4 [Pan troglodytes]
 0.0 [1..1349] [1..1349]
gi|68388302 - gi|68388302|ref|XP_696268.1| PREDICTED: similar to slow myosin heavy chain 1 [Danio rerio]
 0.0 [171..1270] [1829..2904]
MYH4_PIG - Myosin-4 OS=Sus scrofa GN=MYH4 PE=2 SV=1
 0.0 [149..1266] [805..1927]
gi|165973992, gi... - gi|83026762|gb|ABB96408.1| fast myosin heavy chain 2X [Canis familiaris], gi|165973992|ref|NP_001107...
 0.0 [152..1266] [824..1943]
gi|109488222 - gi|109488222|ref|XP_001077587.1| PREDICTED: similar to Myosin heavy chain, skeletal muscle, adult 2 ...
 0.0 [152..1290] [802..1945]

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Predicted Domain #1
Region A:
Residues: [1-182] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKKIRICHIF TFYSWMSYDV LFQRTELGAL EIWRQLICAH VCICVGWLYL RDRVCSKKDI  60
   61 ILRTEQNSGR TILIKAVTEK NFETKDFRAS LENGVLLCDL INKLKPGVIK KINRLSTPIA 120
  121 GLDNINVFLK ACEQIGLKEA QLFHPGDLQD LSNRVTVKQE ETDRRVKNVL ITLYWLGRKA 180
  181 QS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.09691
Match: 1wynA
Description: Solution structure of the CH domain of human calponin-2
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [183-533] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NPYYNGPHLN LKAFENLLGQ ALTKALEDSS FLKRSGRDSG YGDIWCPERG EFLAPPRHHK  60
   61 REDSFESLDS LGSRSLTSCS SDITLRGGRE GFESDTDSEF TFKMQDYNKD DMSYRRISAV 120
  121 EPKTALPFNR FLPNKSRQPS YVPAPLRKKK PDKHEDNRRS WASPVYTEAD GTFSRLFQKI 180
  181 YGENGSKSMS DVSAEDVQNL RQLRYEEMQK IKSQLKEQDQ KWQDDLAKWK DRRKSYTSDL 240
  241 QKKKEEREEI EKQALEKSKR SSKTFKEMLQ DRESQNQKST VPSRRRMYSF DDVLEEGKRP 300
  301 PTMTVSEASY QSERVEEKGA TYPSEIPKED STTFAKREDR VTTEIQLPSQ S

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.0
Match: 1i84S
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [534-624] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PVEEQSPASL SSLRSRSTQM ESTRVSASLP RSYRKTDTVR LTSVVTPRPF GSQTRGISSL  60
   61 PRSYTMDDAW KYNGDVEDIK RTPNNVVSTP A

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.30103
Match: 2tmaA
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [625-672] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSPDASQLAS SLSSQKEVAA TEEDVTRLPS PTSPFSSLSQ DQAATSKA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [673-810] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TLSSTSGLDL MSESGEGEIS PQREVSRSQD QFSDMRISIN QTPGKSLDFG FTIKWDIPGI  60
   61 FVASVEAGSP AEFSQLQVDD EIIAINNTKF SYNDSKEWEE AMAKAQETGH LVMDVRRYGK 120
  121 AGSPETKWID ATSGIYNS

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.27
Match: 1uf1A
Description: Solution structure of the second PDZ domain of human KIAA1526 protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein binding 2.84584532725855 bayes_pls_golite062009
binding 2.64995560308714 bayes_pls_golite062009
beta-catenin binding 1.37028689668988 bayes_pls_golite062009
receptor binding 0.626200183605506 bayes_pls_golite062009
protein domain specific binding 0.452874488417277 bayes_pls_golite062009
cell adhesion molecule binding 0.37866485872822 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [811-904] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKSSNLSVTT DFSESLQSSN IESKEINGIH DESNAFESKA SESISLKNLK RRSQFFEQGS  60
   61 SDSVVPDLPV PTISAPSRWV WDQEEERKRQ ERWQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [905-1217] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KEQDRLLQEK YQREQEKLRE EWQRAKQEAE RENSKYLDEE LMVLSSNSMS LTTREPSLAT  60
   61 WEATWSEGSK SSDREGTRAG EEERRQPQEE VVHEDQGKKP QDQLVIERER KWEQQLQEEQ 120
  121 EQKRLQAEAE EQKRPAEEQK RQAEIERETS VRIYQYRRPV DSYDIPKTEE ASSGFLPGDR 180
  181 NKSRSTTELD DYSTNKNGNN KYLDQIGNMT SSQRRSKKEQ VPSGAELERQ QILQEMRKRT 240
  241 PLHNDNSWIR QRSASVNKEP VSLPGIMRRG ESLDNLDSPR SNSWRQPPWL NQPTGFYASS 300
  301 SVQDFSRPPP QLV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.69897
Match: 2i1jA
Description: No description for 2i1jA was found.

Predicted Domain #8
Region A:
Residues: [1218-1277] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STSNRAYMRN PSSSVPPPSA GSVKTSTTGV ATTQSPTPRS HSPSASQSGS QLRNRSVSGK  60
   61

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #9
Region A:
Residues: [1278-1349] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RICSYCNNIL GKGAAMIIES LGLCYHLHCF KCVACECDLG GSSSGAEVRI RNHQLYCNDC  60
   61 YLRFKSGRPT AM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.30103
Match: 2curA
Description: Solution structure of Skeletal muscle LIM-protein 1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.47976310866464 bayes_pls_golite062009
protein binding 2.06940714324924 bayes_pls_golite062009
receptor activity 1.70176463088443 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle