YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|5102630, gi\|2...
Organism:	Homo sapiens
Length:	492 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|5102630, gi|2....

Description	E-value	Query Range	Subject Range
HGNC:5003\|MIM:60... - box domain containing 4 gi\|208967869, gi... - gi\|208967869\|dbj\|BAG72580.1\| high-mobility group protein 2-like 1 [synthetic construct], gi\|10945192... HMGXB4 - HMG box domain containing 4	2.0E-67	[1..492]	[110..601]
gi\|114686112 - gi\|114686112\|ref\|XP_515098.2\| PREDICTED: high-mobility group protein 2-like 1 isoform 4 [Pan troglod...	3.0E-67	[1..492]	[110..601]
gi\|30794254, gi\|... - gi\|30794254\|ref\|NP_821136.1\| HMG box domain containing 4 [Mus musculus], gi\|29436851\|gb\|AAH49800.1\| ...	4.0E-67	[1..492]	[110..594]
gi\|76619085 - gi\|76619085\|ref\|XP_886550.1\| PREDICTED: similar to high-mobility group protein 2-like 1 isoform b is...	3.0E-66	[1..492]	[106..598]
gi\|109508402, gi... - ref\|XP_226315.2\| similar to High mobility group box 2-like 1 [Rattus norvegicus], gi\|109508402\|ref\|X...	3.0E-66	[1..492]	[110..594]
gi\|109093991 - gi\|109093991\|ref\|XP_001113091.1\| PREDICTED: similar to high-mobility group protein 2-like 1 isoform ...	6.0E-66	[1..492]	[110..601]
gi\|73969226 - gi\|73969226\|ref\|XP_850802.1\| PREDICTED: similar to high-mobility group protein 2-like 1 isoform b is...	4.0E-65	[1..492]	[110..600]

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Predicted Domain #1

Region A:
Residues: [1-187]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDLLKAITSP LAAGSKPSKK TGEKSSGSSS HSESKKEHHR KKVSGSSGEL PLEDGGSHKS  60
   61 KKMKPLYVNT ETLTLREPDG LKMKLILSPK EKGSSSVDEE SFQYPSQQAT VKKSSKKSAR 120
  121 DEQGALLLGH ELQSFLKTAR KKHKSSSDAH SSPGPEGCGS DASQFAESHS ANLDLSGLEP 180
  181 ILVESDS

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [188-283]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSGGELEAGE LVIDDSYREI KKKKKSKKSK KKKDKEKHKE KRHSKSKRSL GLSAVPVGEV  60
   61 TVTSGPPPSI PYAGAAAPPL PLPGLHTDGH SEKKKK

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [284-492]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KEEKDKERER GEKPKKKNMS AYQVFCKEYR VTIVADHPGI DFGELSKKLA EVWKQLPEKD  60
   61 KLIWKQKAQY LQHKQNKAEA TTVKRKASSS EGSMKVKASS VGVLSPQKKS PPTTMLLPAS 120
  121 PAKAPETEPI DVAAHLQLLG ESLSLIGHRL QETEGMVAVS GSLSVLLDSI ICALGPLACL 180
  181 TTQLPELNGC PKQVLSNTLD NIAYIMPGL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	27.69897
Match:	2gzkA
Description:	No description for 2gzkA was found.

Predicted functions:

Term	Confidence	Notes
binding	0.927928103499335	bayes_pls_golite062009
nucleic acid binding	0.38664561645052	bayes_pls_golite062009
DNA binding	0.37554038880732	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: