YRC Public Data Repository - Protein Structure Prediction

Protein:	YNFE_ECOLI
Organism:	Escherichia coli
Length:	808 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YNFE_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|91072371, gi\|... - gi\|91210797\|ref\|YP_540783.1\| putative dimethyl sulfoxide reductase chain YnfE precursor [Escherichia... gi\|227836985, gi... - gi\|227886056\|ref\|ZP_04003861.1\| dimethyl sulfoxide reductase chain ynfE precursor [Escherichia coli ... gi\|226900283, gi... - gi\|237705526\|ref\|ZP_04536007.1\| conserved hypothetical protein [Escherichia sp. 3_2_53FAA], gi\|22690... gi\|26108235, gi\|... - gi\|26247832\|ref\|NP_753872.1\| putative dimethyl sulfoxide reductase chain ynfE precursor [Escherichia... gi\|117623773, gi... - gi\|117623773\|ref\|YP_852686.1\| putative dimethyl sulfoxide reductase chain YnfE precursor [Escherichi... gi\|218365226, gi... - gi\|218558457\|ref\|YP_002391370.1\| oxidoreductase subunit [Escherichia coli S88], gi\|218365226\|emb\|CAR...	794.0	[0..1]	[808..1]
gi\|75212924, gi\|... - gi\|75212924\|ref\|ZP_00712922.1\| COG0243: Anaerobic dehydrogenases, typically selenocysteine-containin...	793.0	[0..1]	[808..1]
gi\|50199178 - gi\|50199178\|emb\|CAE11227.1\| putative dimethyl sulfoxide reductase chain ynfE precursor [Escherichia ...	792.0	[0..1]	[808..1]
gi\|208818717, gi... - gi\|208818717\|ref\|ZP_03259037.1\| anaerobic dimethyl sulfoxide reductase, A subunit YnfE [Escherichia ... gi\|208731055, gi... - gi\|208816712\|ref\|ZP_03257832.1\| anaerobic dimethyl sulfoxide reductase, A subunit YnfE [Escherichia ... gi\|217328963, gi... - gi\|217328963\|ref\|ZP_03445044.1\| anaerobic dimethyl sulfoxide reductase, A subunit YnfE [Escherichia ... gi\|209400979, gi... - gi\|209400979\|ref\|YP_002270658.1\| anaerobic dimethyl sulfoxide reductase, A subunit YnfE [Escherichia... gi\|15831547, gi\|... - gi\|15831547\|ref\|NP_310320.1\| putative oxidoreductase major subunit [Escherichia coli O157:H7], gi\|13... gi\|189376909, gi... - gi\|189376909\|gb\|EDU95325.1\| anaerobic dimethyl sulfoxide reductase, A subunit YnfE [Escherichia col... gi\|209770060, gi... - pir\|\|B85764 probable oxidoreductase, major subunit Z2575 [imported] - Escherichia coli (strain O157:... gi\|168789418, gi... - gi\|189370978\|gb\|EDU89394.1\| anaerobic dimethyl sulfoxide reductase, A subunit YnfE [Escherichia col... gi\|208725046, gi... - gi\|208810530\|ref\|ZP_03252406.1\| anaerobic dimethyl sulfoxide reductase, A subunit YnfE [Escherichia ... gi\|12515562, gi\|... - gi\|15802001\|ref\|NP_288022.1\| putative oxidoreductase, major subunit [Escherichia coli O157:H7 EDL933... gi\|195938976 - gi\|195938976\|ref\|ZP_03084358.1\| putative oxidoreductase major subunit [Escherichia coli O157:H7 str.... gi\|168763715, gi... - gi\|189366208\|gb\|EDU84624.1\| anaerobic dimethyl sulfoxide reductase, A subunit YnfE [Escherichia coli... gi\|189355539, gi... - gi\|189355539\|gb\|EDU73958.1\| anaerobic dimethyl sulfoxide reductase, A subunit YnfE [Escherichia col... gi\|188999236, gi... - gi\|188999236\|gb\|EDU68222.1\| anaerobic dimethyl sulfoxide reductase, A subunit YnfE [Escherichia coli... gi\|187768708, gi... - gi\|187768708\|gb\|EDU32552.1\| anaerobic dimethyl sulfoxide reductase, A subunit YnfE [Escherichia coli... gi\|188015277, gi... - gi\|188015277\|gb\|EDU53399.1\| anaerobic dimethyl sulfoxide reductase, A subunit YnfE [Escherichia coli... gi\|254793204, gi... - gi\|254793204\|ref\|YP_003078041.1\| oxidoreductase subunit [Escherichia coli O157:H7 str. TW14359], gi\|... gi\|15831547, gi\|... - gi\|15831547\|ref\|NP_310320.1\| putative oxidoreductase major subunit [Escherichia coli O157:H7 str. Sa...	785.0	[0..1]	[808..1]
gi\|83587922, gi\|... - gi\|83587922\|ref\|ZP_00926548.1\| COG0243: Anaerobic dehydrogenases, typically selenocysteine-containin...	783.0	[0..1]	[808..1]
gi\|75230964 - gi\|75230964\|ref\|ZP_00717413.1\| COG0243: Anaerobic dehydrogenases, typically selenocysteine-containin...	782.0	[0..7]	[808..1]
gi\|75178519 - gi\|75178519\|ref\|ZP_00698565.1\| COG0243: Anaerobic dehydrogenases, typically selenocysteine-containin...	782.0	[0..7]	[808..1]
gi\|75239770 - gi\|75239770\|ref\|ZP_00723731.1\| COG0243: Anaerobic dehydrogenases, typically selenocysteine-containin...	782.0	[0..7]	[808..1]
gi\|75195667 - gi\|75195667\|ref\|ZP_00705737.1\| COG0243: Anaerobic dehydrogenases, typically selenocysteine-containin...	778.0	[0..7]	[808..1]
gi\|75190627 - gi\|75190627\|ref\|ZP_00703894.1\| COG0243: Anaerobic dehydrogenases, typically selenocysteine-containin...	777.0	[0..7]	[808..1]

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Predicted Domain #1

Region A:
Residues: [1-808]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKNERMVGI SRRTLVKSTA IGSLALAAGG FSLPFTLRNA AAAVQQAREK VVWGACSVNC  60
   61 GSRCALRLHV KDNEVTWVET DNTGSDEYGN HQVRACLRGR SIRRRINHPD RLNYPMKRVG 120
  121 KRGEGKFERI SWDEALDTIA SSLKKTVEQY GNEAVYIQYS SGIVGGNMTR SSPSASAVKR 180
  181 LMNCYGGSLN QYGSYSTAQI SCAMPYTYGS NDGNSTTDIE NSKLVVMFGN NPAETRMSGG 240
  241 GITYLLEKAR EKSNAKMIVI DPRYTDTAAG REDEWLPIRP GTDAALVAGI AWVLINENLV 300
  301 DQPFLDKYCV GYDEKTLPAD APKNGHYKAY ILGEGDDKTA KTPQWASQIT GIPEDRIIKL 360
  361 AREIGTAKPA YICQGWGPQR QANGELTARA IAMLPILTGN VGISGGNSGA RESTYTITIE 420
  421 RLPVLDNPVK TSISCFSWTD AIDHGPQMTA IRDGVRGKDK LDVPIKFIWN YAGNTLVNQH 480
  481 SDINKTHEIL QDESKCEMIV VIENFMTSSA KYADILLPDL MTVEQEDIIP NDYAGNMGYL 540
  541 IFLQPVTSEK FERKPIYWIL SEVAKRLGPD VYQKFTEGRT QEQWLQHLYA KMLAKDPALP 600
  601 SYDELKKMGI YKRKDPNGHF VAYKAFRDDP EANPLKTPSG KIEIYSSRLA EIARTWELEK 660
  661 DEVISPLPVY ASTFEGWNSP ERRTFPLQLF GFHYKSRTHS TYGNIDLLKA ACRQEVWINP 720
  721 IDAQKRGIAN GDMVRVFNHR GEVRLPAKVT PRILPGVSAM GQGAWHEANM SGDKIDHGGC 780
  781 VNTLTTLRPS PLAKGNPQHT NLVEIEKI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	152.0
Match:	1dmrA
Description:	OXIDIZED DMSO REDUCTASE FROM RHODOBACTER CAPSULATUS
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
nitrate reductase activity	13.0318477645691	bayes_pls_golite062009
oxidoreductase activity, acting on other nitrogenous compounds as donors	12.1969883329386	bayes_pls_golite062009
trimethylamine-N-oxide reductase activity	8.75612712598998	bayes_pls_golite062009
4 iron, 4 sulfur cluster binding	6.81363258746891	bayes_pls_golite062009
formate dehydrogenase activity	6.68295624624715	bayes_pls_golite062009
iron-sulfur cluster binding	5.7442724322527	bayes_pls_golite062009
metal cluster binding	5.7442724322527	bayes_pls_golite062009
molybdenum ion binding	3.31971125919934	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor	2.54554723799271	bayes_pls_golite062009
catalytic activity	1.93875927205186	bayes_pls_golite062009
oxidoreductase activity	1.8662488889516	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	1.84836110501265	bayes_pls_golite062009
carbon-carbon lyase activity	1.29705810885029	bayes_pls_golite062009
carboxy-lyase activity	1.27093915206504	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	0.968773059107375	bayes_pls_golite062009
lyase activity	0.603656450860878	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH	0.134493772161849	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: