YRC Public Data Repository - Protein Structure Prediction

Protein:	YFHP_ECOLI, ISCR...
Organism:	Escherichia coli
Length:	162 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YFHP_ECOLI, ISCR....

Description	E-value	Query Range	Subject Range
gi\|45442337, gi\|... - gi\|45442337\|ref\|NP_993876.1\| DNA-binding transcriptional regulator IscR [Yersinia pestis biovar Micr... gi\|186699296, gi... - gi\|186896270\|ref\|YP_001873382.1\| DNA-binding transcriptional regulator IscR [Yersinia pseudotubercul... gi\|169750055, gi... - gi\|170023521\|ref\|YP_001720026.1\| DNA-binding transcriptional regulator IscR [Yersinia pseudotubercul... gi\|21958101, gi\|... - gi\|22125232\|ref\|NP_668655.1\| DNA-binding transcriptional regulator IscR [Yersinia pestis KIM], gi\|21...	180.0	[0..1]	[162..22]
ISCR_YERPA - HTH-type transcriptional regulator IscR OS=Yersinia pestis bv. Antiqua (strain Antiqua) GN=iscR PE=3... ISCR_YERPN - HTH-type transcriptional regulator IscR OS=Yersinia pestis bv. Antiqua (strain Nepal516) GN=iscR PE=... gi\|229899050, gi... - gi\|229899050\|ref\|ZP_04514194.1\| Iron-sulfur cluster regulator IscR [Yersinia pestis biovar Orientali... gi\|229701292, gi... - gi\|229895486\|ref\|ZP_04510657.1\| Iron-sulfur cluster regulator IscR [Yersinia pestis Pestoides A], gi... gi\|229838481, gi... - gi\|229838481\|ref\|ZP_04458640.1\| Iron-sulfur cluster regulator IscR [Yersinia pestis biovar Orientali... ISCR_YERPS - HTH-type transcriptional regulator iscR OS=Yersinia pseudotuberculosis GN=iscR PE=3 SV=1 ISCR_YERPG - HTH-type transcriptional regulator IscR OS=Yersinia pestis bv. Antiqua (strain Angola) GN=iscR PE=3 ... ISCR_YERP3 - HTH-type transcriptional regulator IscR OS=Yersinia pseudotuberculosis serotype O:1b (strain IP 3175... gi\|165928257, gi... - gi\|165928257\|ref\|ZP_02224089.1\| iron-sulfur cluster assembly transcription factor IscR [Yersinia pes... gi\|165992647, gi... - gi\|166008265\|ref\|ZP_02229163.1\| iron-sulfur cluster assembly transcription factor IscR [Yersinia pes... gi\|166212578, gi... - gi\|166212578\|ref\|ZP_02238613.1\| iron-sulfur cluster assembly transcription factor IscR [Yersinia pes... gi\|167398867, gi... - gi\|167398867\|ref\|ZP_02304391.1\| iron-sulfur cluster assembly transcription factor IscR [Yersinia pes... ISCR_YERPE - HTH-type transcriptional regulator IscR OS=Yersinia pestis GN=iscR PE=3 SV=1 ISCR_YERPP - HTH-type transcriptional regulator IscR OS=Yersinia pestis (strain Pestoides F) GN=iscR PE=3 SV=1 gi\|167421227, gi... - gi\|167421227\|ref\|ZP_02312980.1\| iron-sulfur cluster assembly transcription factor IscR [Yersinia pes... gi\|149365356, gi... - gi\|149365356\|ref\|ZP_01887391.1\| Fe-S cluster-containing transcription factor [Yersinia pestis CA88-4... gi\|167423261, gi... - gi\|167423261\|ref\|ZP_02315014.1\| iron-sulfur cluster assembly transcription factor IscR [Yersinia pes... gi\|218929956, gi... - gi\|218929956\|ref\|YP_002347831.1\| DNA-binding transcriptional regulator IscR [Yersinia pestis CO92], ... ISCR_YERPS - HTH-type transcriptional regulator IscR OS=Yersinia pseudotuberculosis serotype I (strain IP32953) G...	180.0	[0..1]	[162..1]
ISCR_YERE8 - HTH-type transcriptional regulator IscR OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain... gi\|77976668 - gi\|77976668\|ref\|ZP_00832144.1\| COG1959: Predicted transcriptional regulator [Yersinia intermedia ATC... gi\|238723775, gi... - gi\|77974688\|ref\|ZP_00830227.1\| COG1959: Predicted transcriptional regulator [Yersinia frederiksenii ...	180.0	[0..1]	[162..1]
ISCR_PHOLL - HTH-type transcriptional regulator IscR OS=Photorhabdus luminescens subsp. laumondii (strain DSM 151... ISCR_PHOLL - HTH-type transcriptional regulator iscR OS=Photorhabdus luminescens subsp. laumondii GN=iscR PE=3 SV...	179.0	[0..1]	[161..1]
gi\|238765525, gi... - gi\|238765525\|ref\|ZP_04626441.1\| HTH-type transcriptional regulator iscR [Yersinia kristensenii ATCC ... gi\|238719501, gi... - gi\|77963408\|ref\|ZP_00827218.1\| COG1959: Predicted transcriptional regulator [Yersinia mollaretii ATC...	179.0	[0..1]	[162..1]
gi\|89072688, gi\|... - gi\|89072688\|ref\|ZP_01159253.1\| hypothetical transcriptional regulator [Photobacterium sp. SKA34], gi...	179.0	[0..1]	[162..13]
gi\|227008814, gi... - gi\|227080926\|ref\|YP_002809477.1\| hypothetical protein VCM66_0705 [Vibrio cholerae M66-2], gi\|2270088... gi\|121628541, gi... - gi\|121729724\|ref\|ZP_01682165.1\| conserved hypothetical protein [Vibrio cholerae V52], gi\|121628541\|g... gi\|121591450, gi... - gi\|121591450\|ref\|ZP_01678726.1\| conserved hypothetical protein [Vibrio cholerae 2740-80], gi\|1215467... gi\|124120246, gi... - gi\|153220682\|ref\|ZP_01951793.1\| conserved hypothetical protein [Vibrio cholerae MAK 757], gi\|1241202... gi\|153216250, gi... - gi\|153216250\|ref\|ZP_01950350.1\| conserved hypothetical protein [Vibrio cholerae 1587], gi\|124114395\|... gi\|254843589, gi... - gi\|254847884\|ref\|ZP_05237234.1\| conserved hypothetical protein [Vibrio cholerae MO10], gi\|254843589\|... gi\|153800571, gi... - gi\|153800571\|ref\|ZP_01955157.1\| conserved hypothetical protein [Vibrio cholerae MZO-3], gi\|124123860... gi\|153817260, gi... - gi\|153817260\|ref\|ZP_01969927.1\| conserved hypothetical protein [Vibrio cholerae NCTC 8457], gi\|12651... gi\|125622399, gi... - gi\|254225012\|ref\|ZP_04918626.1\| conserved hypothetical protein [Vibrio cholerae V51], gi\|194537786\|r... gi\|150421369, gi... - gi\|254222201\|ref\|ZP_04916074.1\| conserved hypothetical protein [Vibrio cholerae RC385], gi\|194536575... gi\|153822734, gi... - gi\|153822734\|ref\|ZP_01975401.1\| conserved hypothetical protein [Vibrio cholerae B33], gi\|126519765\|g... gi\|153829399, gi... - gi\|153829399\|ref\|ZP_01982066.1\| conserved hypothetical protein [Vibrio cholerae 623-39], gi\|14887511... gi\|153824617, gi... - gi\|153824617\|ref\|ZP_01977284.1\| conserved hypothetical protein [Vibrio cholerae MZO-2], gi\|149741835... gi\|227012571, gi... - gi\|227117121\|ref\|YP_002819017.1\| hypothetical protein VC395_0764 [Vibrio cholerae O395], gi\|22701257... gi\|15640766, gi\|... - gi\|9655192\|gb\|AAF93912.1\| conserved hypothetical protein [Vibrio cholerae O1 biovar El Tor str. N169... gi\|11354549 - pir\|\|F82285 conserved hypothetical protein VC0747 [imported] - Vibrio cholerae (strain N16961 serogr... gi\|254285465, gi... - gi\|254285465\|ref\|ZP_04960429.1\| conserved hypothetical protein [Vibrio cholerae AM-19226], gi\|197752...	178.0	[0..1]	[160..16]
ISCR_XENNE - HTH-type transcriptional regulator iscR OS=Xenorhabdus nematophilus GN=iscR PE=3 SV=1 ISCR_XENNA - HTH-type transcriptional regulator IscR OS=Xenorhabdus nematophila (strain ATCC 19061 / DSM 3370 / L...	178.0	[0..1]	[162..1]
ISCR_ERWCT - HTH-type transcriptional regulator iscR OS=Erwinia carotovora subsp. atroseptica GN=iscR PE=3 SV=1 ISCR_PECAS - HTH-type transcriptional regulator IscR OS=Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-...	177.0	[0..1]	[162..1]
gi\|114771461, gi... - gi\|114771461\|ref\|ZP_01448876.1\| hypothetical transcriptional regulator [alpha proteobacterium HTCC22... gi\|114771461 - gi\|114771461\|ref\|ZP_01448876.1\| hypothetical transcriptional regulator [alpha proteobacterium HTCC22... gi\|221133857 - gi\|221133857\|ref\|ZP_03560162.1\| transcriptional regulator, BadM/Rrf2 family protein [Glaciecola sp. ...	174.0	[0..1]	[161..1]

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Predicted Domain #1

Region A:
Residues: [1-162]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRLTSKGRYA VTAMLDVALN SEAGPVPLAD ISERQGISLS YLEQLFSRLR KNGLVSSVRG  60
   61 PGGGYLLGKD ASSIAVGEVI SAVDESVDAT RCQGKGGCQG GDKCLTHALW RDLSDRLTGF 120
  121 LNNITLGELV NNQEVLDVSG RQHTHDAPRT RTQDAIDVKL RA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	25.39794
Match:	1ylfA
Description:	X-ray crystal structure of BC1842 protein from Bacillus cereus, a member of the Rrf2 family of putative transcription regulators.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	4.03124001296907	bayes_pls_golite062009
DNA binding	3.6318990385733	bayes_pls_golite062009
nucleic acid binding	3.62005343025125	bayes_pls_golite062009
transcription factor activity	2.87763604150694	bayes_pls_golite062009
binding	2.62737887048829	bayes_pls_golite062009
sequence-specific DNA binding	1.11065232292582	bayes_pls_golite062009
transcription activator activity	1.0291156554117	bayes_pls_golite062009
transcription repressor activity	0.910965849978864	bayes_pls_golite062009
protein binding	0.498124455750984	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.303382870006146	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: