YRC Public Data Repository - Protein Structure Prediction

Protein:	YEIE_ECOLI
Organism:	Escherichia coli
Length:	293 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YEIE_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|91191158, gi\|... - gi\|91224247\|ref\|ZP_01259510.1\| putative transcription regulator protein [Vibrio alginolyticus 12G01]...	286.0	[0..1]	[290..1]
gi\|27367995, gi\|... - gi\|27367995\|ref\|NP_763522.1\| transcriptional regulator [Vibrio vulnificus CMCP6], gi\|27359568\|gb\|AAO...	285.0	[0..1]	[290..1]
gi\|28900071, gi\|... - gi\|28900071\|ref\|NP_799726.1\| putative transcription regulator protein [Vibrio parahaemolyticus RIMD ... gi\|28808354 - gi\|28808354\|dbj\|BAC61559.1\| putative transcription regulator protein [Vibrio parahaemolyticus RIMD 2...	284.0	[0..5]	[290..4]
gi\|37200667, gi\|... - gi\|37676126\|ref\|NP_936522.1\| transcriptional regulator [Vibrio vulnificus YJ016], gi\|37200667\|dbj\|BA...	284.0	[0..1]	[290..1]
gi\|116185384, gi... - gi\|75856032\|ref\|ZP_00763668.1\| COG0583: Transcriptional regulator [Vibrio sp. Ex25], gi\|254227935\|re...	284.0	[0..5]	[290..4]
gi\|114045851, gi... - gi\|78689367\|ref\|ZP_00854030.1\| transcriptional regulator, LysR family [Shewanella sp. MR-7], gi\|7851...	282.0	[0..3]	[291..1]
gi\|117614564, gi... - gi\|78685922\|ref\|ZP_00850696.1\| transcriptional regulator, LysR family [Shewanella sp. ANA-3], gi\|785...	282.0	[0..5]	[291..4]
SO0369 - transcriptional regulator LysR family gi\|24345816, gi\|... - gi\|24371967\|ref\|NP_716009.1\| LysR family transcriptional regulator [Shewanella oneidensis MR-1], gi\|...	279.0	[0..5]	[292..4]
gi\|82406257, gi\|... - gi\|82495665\|ref\|ZP_00881239.1\| transcriptional regulator, LysR family [Shewanella sp. MR-4], gi\|8240...	278.0	[0..3]	[291..1]
gi\|82719568, gi\|... - gi\|82743075\|ref\|ZP_00905742.1\| transcriptional regulator, LysR family [Shewanella sp. W3-18-1], gi\|8...	275.0	[0..5]	[290..4]

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Predicted Domain #1

Region A:
Residues: [1-293]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHITLRQLEV FAEVLKSGST TQASVMLALS QSAVSAALTD LEGQLGVQLF DRVGKRLVVN  60
   61 EHGRLLYPRA LALLEQAVEI EQLFREDNGA IRIYASSTIG NYILPAVIAR YRHDYPQLPI 120
  121 ELSVGNSQDV MQAVLDFRVD IGFIEGPCHS TEIISEPWLE DELVVFAAPT SPLARGPVTL 180
  181 EQLAAAPWIL RERGSGTREI VDYLLLSHLP KFEMAMELGN SEAIKHAVRH GLGISCLSRR 240
  241 VIEDQLQAGT LSEVAVPLPR LMRTLWRIHH RQKHLSNALR RFLDYCDPAN VPR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	45.30103
Match:	1al3A
Description:	COFACTOR BINDING FRAGMENT OF CYSB FROM KLEBSIELLA AEROGENES
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	2.06846313752146	bayes_pls_golite062009
transcription factor activity	1.54776226622667	bayes_pls_golite062009
DNA binding	1.53867658911479	bayes_pls_golite062009
nucleic acid binding	1.45471488657915	bayes_pls_golite062009
binding	1.29220115989941	bayes_pls_golite062009
catalytic activity	1.04475291968158	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: