YRC Public Data Repository - Protein Structure Prediction

Protein:	YAFC_ECOLI
Organism:	Escherichia coli
Length:	304 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YAFC_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|91191158, gi\|... - gi\|91224247\|ref\|ZP_01259510.1\| putative transcription regulator protein [Vibrio alginolyticus 12G01]...	309.0	[0..5]	[301..4]
gi\|28900071, gi\|... - gi\|28900071\|ref\|NP_799726.1\| putative transcription regulator protein [Vibrio parahaemolyticus RIMD ... gi\|28808354 - gi\|28808354\|dbj\|BAC61559.1\| putative transcription regulator protein [Vibrio parahaemolyticus RIMD 2...	308.0	[0..5]	[301..4]
gi\|116185384, gi... - gi\|75856032\|ref\|ZP_00763668.1\| COG0583: Transcriptional regulator [Vibrio sp. Ex25], gi\|254227935\|re...	307.0	[0..5]	[301..4]
gi\|27367995, gi\|... - gi\|27367995\|ref\|NP_763522.1\| transcriptional regulator [Vibrio vulnificus CMCP6], gi\|27359568\|gb\|AAO...	305.0	[0..1]	[300..1]
gi\|37200667, gi\|... - gi\|37676126\|ref\|NP_936522.1\| transcriptional regulator [Vibrio vulnificus YJ016], gi\|37200667\|dbj\|BA...	305.0	[0..1]	[300..1]
gi\|114045851, gi... - gi\|78689367\|ref\|ZP_00854030.1\| transcriptional regulator, LysR family [Shewanella sp. MR-7], gi\|7851...	297.0	[0..1]	[295..1]
gi\|117614564, gi... - gi\|78685922\|ref\|ZP_00850696.1\| transcriptional regulator, LysR family [Shewanella sp. ANA-3], gi\|785...	297.0	[0..5]	[295..4]
gi\|82406257, gi\|... - gi\|82495665\|ref\|ZP_00881239.1\| transcriptional regulator, LysR family [Shewanella sp. MR-4], gi\|8240...	294.0	[0..1]	[294..1]
gi\|87118407, gi\|... - gi\|87118407\|ref\|ZP_01074306.1\| putative transcription regulator protein [Marinomonas sp. MED121], gi...	294.0	[0..4]	[300..3]
SO0369 - transcriptional regulator LysR family gi\|24345816, gi\|... - gi\|24371967\|ref\|NP_716009.1\| LysR family transcriptional regulator [Shewanella oneidensis MR-1], gi\|...	294.0	[0..5]	[295..4]

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Predicted Domain #1

Region A:
Residues: [1-304]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKATSEELAI FVSVVESGSF SRAAEQLGQA NSAVSRAVKK LEMKLGVSLL NRTTRQLSLT  60
   61 EEGERYFRRV QSILQEMAAA ESEIMETRNT PRGLLRIDAA TPVVLHFLMP LIKPFRERYP 120
  121 EVTLSLVSSE TIINLIERKV DVAIRAGTLT DSSLRARPLF NSYRKIIASP DYISRYGKPE 180
  181 TIDDLKQHIC LGFTEPASLN TWPIARSDGQ LHEVKYGLSS NSGETLKQLC LSGNGIACLS 240
  241 DYMIDKEIAR GELVELMADK VLPVEMPFSA VYYSDRAVST RIRAFIDFLS EHVKTAPGGA 300
  301 VREA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	42.39794
Match:	1al3A
Description:	COFACTOR BINDING FRAGMENT OF CYSB FROM KLEBSIELLA AEROGENES
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	2.06846313752146	bayes_pls_golite062009
transcription factor activity	1.54776226622667	bayes_pls_golite062009
DNA binding	1.53867658911479	bayes_pls_golite062009
nucleic acid binding	1.45471488657915	bayes_pls_golite062009
binding	1.29220115989941	bayes_pls_golite062009
catalytic activity	1.04475291968158	bayes_pls_golite062009
protein binding	0.0639574144110515	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: