YRC Public Data Repository - Protein Structure Prediction

Protein:	TRPC_SALTI
Organism:	Salmonella typhi
Length:	452 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TRPC_SALTI.

Description	E-value	Query Range	Subject Range
gi\|56413350, gi\|... - gi\|56413350\|ref\|YP_150425.1\| bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthran... gi\|197362275, gi... - gi\|197362275\|ref\|YP_002141912.1\| bifunctional indole-3-glycerol phosphate synthase/phosphoribosylant...	0.0	[1..452]	[1..452]
TRPC_SALTY - Tryptophan biosynthesis protein trpCF OS=Salmonella typhimurium GN=trpC PE=3 SV=1 TRPC_SALTY - Tryptophan biosynthesis protein TrpCF OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720... gi\|205325057, gi... - gi\|205325057\|gb\|EDZ12896.1\| tryptophan biosynthesis protein trpCF [Salmonella enterica subsp. enteri... lcl\|NC_016856.1_... - [gene=trpC] [protein=bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate is... TRPC_SALTY - Tryptophan biosynthesis protein TrpCF OS=Salmonella typhimurium GN=trpC PE=3 SV=1	0.0	[1..452]	[1..452]
gi\|62127924, gi\|... - gi\|62180291\|ref\|YP_216708.1\| bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthran...	0.0	[1..452]	[1..452]
gi\|218365016, gi... - gi\|218558247\|ref\|YP_002391160.1\| bifunctional indole-3-glycerol phosphate synthase/phosphoribosylant... gi\|117623523, gi... - gi\|117623523\|ref\|YP_852436.1\| bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthra... gi\|237705286, gi... - gi\|237705286\|ref\|ZP_04535767.1\| anthranilate isomerase [Escherichia sp. 3_2_53FAA], gi\|226900043\|gb\|... gi\|91072128, gi\|... - gi\|91210554\|ref\|YP_540540.1\| bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthran...	0.0	[1..452]	[1..452]
gi\|775166 - gi\|775166\|gb\|AAB60039.1\| anthranilate isomerase	0.0	[1..452]	[1..452]
gi\|191171056, gi... - gi\|75242062\|ref\|ZP_00725856.1\| COG0134: Indole-3-glycerol phosphate synthase [Escherichia coli F11],...	0.0	[1..452]	[2..453]

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Predicted Domain #1

Region A:
Residues: [1-452]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQTVLAKIVA DKAIWVEARK QQQPLASFQN EIQPSTRHFY DALQGARTAF ILECKKASPS  60
   61 KGVIRDDFDP ARIASIYQHY ASAISVLTDE KYFQGSFDFL PVVSQSAPQP ILCKDFIIDP 120
  121 YQIYLARYYQ ADACLLMLSV LDDEQYRQLS AVAHSLKMGV LTEISNDEER ERAIALGAKV 180
  181 VGINNRDLRD LSIDLNRTRQ LAPKLGHGVT VISESGINTY GQVRELSHFA NGFLIGSALM 240
  241 AHDDLNAAVR RVLLGENKVC GLTRAQDAKA ACDAGAIYGG LIFVPSSPRA VSVEQAREVI 300
  301 SGAPLQYVGV FKNADIADVC QKAAVLSLSA VQLHGSEDQA YVNALREALP RNVQIWKALS 360
  361 VSNALPARDY HHVDKYIFDN GQGGSGQRFD WSLLQGQPLD DVLLAGGLAA DNCVQAAQVG 420
  421 CAGLDFNSGV ESQPGIKDAR LLASVFQTLR AY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	147.0
Match:	1piiA
Description:	THREE-DIMENSIONAL STRUCTURE OF THE BIFUNCTIONAL ENZYME PHOSPHORIBOSYLANTHRANILATE ISOMERASE: INDOLEGLYCEROLPHOSPHATE SYNTHASE FROM ESCHERICHIA COLI REFINED AT 2.0 ANGSTROMS RESOLUTION
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
tryptophan synthase activity	3.15663465352598	bayes_pls_golite062009
indole-3-glycerol-phosphate synthase activity	3.12120866545322	bayes_pls_golite062009
catalytic activity	2.81275055404078	bayes_pls_golite062009
phosphoribosylanthranilate isomerase activity	2.655130814615	bayes_pls_golite062009
carbon-carbon lyase activity	2.44001937916931	bayes_pls_golite062009
carboxy-lyase activity	1.80978905789979	bayes_pls_golite062009
lyase activity	0.9228652996943	bayes_pls_golite062009
imidazoleglycerol-phosphate synthase activity	0.82314869965119	bayes_pls_golite062009
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity	0.302746738903759	bayes_pls_golite062009
isomerase activity	0.14149405165663	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: