YRC Public Data Repository - Protein Structure Prediction

Protein:	TORA_ECOLI
Organism:	Escherichia coli
Length:	848 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TORA_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|75195184, gi\|... - gi\|75195184\|ref\|ZP_00705254.1\| COG0243: Anaerobic dehydrogenases, typically selenocysteine-containin...	737.0	[0..1]	[848..1]
gi\|83586458, gi\|... - gi\|83586458\|ref\|ZP_00925092.1\| COG0243: Anaerobic dehydrogenases, typically selenocysteine-containin... gi\|253773973, gi... - gi\|254287918\|ref\|YP_003053666.1\| trimethylamine N-oxide (TMAO) reductase I, catalytic subunit [Esche... gi\|251784538, gi... - gi\|251784538\|ref\|YP_002998842.1\| hypothetical protein B21_01007 [Escherichia coli BL21], gi\|24237681... gi\|253973011, gi... - gi\|254161110\|ref\|YP_003044218.1\| trimethylamine N-oxide (TMAO) reductase I, catalytic subunit [Esche...	736.0	[0..1]	[848..1]
gi\|157155850, gi... - gi\|75190062\|ref\|ZP_00703329.1\| COG0243: Anaerobic dehydrogenases, typically selenocysteine-containin...	734.0	[0..1]	[848..1]
gi\|75210277, gi\|... - gi\|75210277\|ref\|ZP_00710439.1\| COG0243: Anaerobic dehydrogenases, typically selenocysteine-containin... gi\|193064603, gi... - gi\|75257441\|ref\|ZP_00728944.1\| COG0243: Anaerobic dehydrogenases, typically selenocysteine-containin...	734.0	[0..1]	[848..1]
TORA_ECOL6 - Trimethylamine-N-oxide reductase 1 OS=Escherichia coli O6 GN=torA PE=3 SV=1 gi\|227884050, gi... - gi\|227884050\|ref\|ZP_04001855.1\| trimethylamine-N-oxide reductase 1 precursor [Escherichia coli 83972... TORA_ECOL6 - Trimethylamine-N-oxide reductase 1 OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN...	734.0	[0..1]	[848..1]
gi\|193070772, gi... - gi\|75234369\|ref\|ZP_00718739.1\| COG0243: Anaerobic dehydrogenases, typically selenocysteine-containin...	733.0	[0..1]	[848..1]
gi\|110342771, gi... - gi\|110641179\|ref\|YP_668909.1\| trimethylamine-N-oxide reductase 1 precursor [Escherichia coli 536], g... gi\|191172465, gi... - gi\|75240605\|ref\|ZP_00724522.1\| COG0243: Anaerobic dehydrogenases, typically selenocysteine-containin...	732.0	[0..1]	[848..1]
gi\|91210090, gi\|... - gi\|91210090\|ref\|YP_540076.1\| trimethylamine-N-oxide reductase 1 precursor [Escherichia coli UTI89], ... gi\|115512319, gi... - gi\|117623195\|ref\|YP_852108.1\| trimethylamine-N-oxide reductase 1 precursor [Escherichia coli APEC O1... gi\|218364657, gi... - gi\|218557888\|ref\|YP_002390801.1\| trimethylamine N-oxide (TMAO) reductase I, catalytic subunit [Esche... gi\|226898232, gi... - gi\|237707022\|ref\|ZP_04537503.1\| trimethylamine-N-oxide reductase 1 [Escherichia sp. 3_2_53FAA], gi\|2...	732.0	[0..1]	[848..1]
gi\|168747386, gi... - gi\|188017974\|gb\|EDU56096.1\| trimethylamine-N-oxide reductase [Escherichia coli O157:H7 str. EC4113],... gi\|189358289, gi... - gi\|189358289\|gb\|EDU76708.1\| trimethylamine-N-oxide reductase [Escherichia coli O157:H7 str. EC4401],... gi\|168763234, gi... - gi\|189366621\|gb\|EDU85037.1\| trimethylamine-N-oxide reductase [Escherichia coli O157:H7 str. EC4501],... gi\|13360612, gi\|... - gi\|15830406\|ref\|NP_309179.1\| trimethylamine N-oxide reductase subunit [Escherichia coli O157:H7 str.... TORA_ECO57 - Trimethylamine-N-oxide reductase 1 OS=Escherichia coli O157:H7 GN=torA PE=3 SV=1 gi\|208737740, gi... - gi\|208822255\|ref\|ZP_03262574.1\| trimethylamine-N-oxide reductase [Escherichia coli O157:H7 str. EC40... gi\|209399846, gi... - gi\|209399846\|ref\|YP_002269723.1\| trimethylamine-N-oxide reductase [Escherichia coli O157:H7 str. EC4... gi\|217322626, gi... - gi\|217326405\|ref\|ZP_03442489.1\| trimethylamine-N-oxide reductase [Escherichia coli O157:H7 str. TW14... gi\|189377117, gi... - gi\|189377117\|gb\|EDU95533.1\| trimethylamine-N-oxide reductase [Escherichia coli O157:H7 str. EC508], ... gi\|195935255 - gi\|195935255\|ref\|ZP_03080637.1\| trimethylamine N-oxide reductase subunit [Escherichia coli O157:H7 s... gi\|208808910, gi... - gi\|208808910\|ref\|ZP_03251247.1\| trimethylamine-N-oxide reductase [Escherichia coli O157:H7 str. EC42... gi\|208732263, gi... - gi\|208815615\|ref\|ZP_03256794.1\| trimethylamine-N-oxide reductase [Escherichia coli O157:H7 str. EC40... gi\|254792254, gi... - gi\|254792254\|ref\|YP_003077091.1\| trimethylamine N-oxide (TMAO) reductase I, catalytic subunit [Esche... gi\|189363174, gi... - gi\|189363174\|gb\|EDU81593.1\| trimethylamine-N-oxide reductase [Escherichia coli O157:H7 str. EC4486],... gi\|25313634, gi\|... - pir\|\|H90772 trimethylamine N-oxide reductase subunit [imported] - Escherichia coli (strain O157:H7, ... gi\|168773684, gi... - gi\|187770377\|gb\|EDU34221.1\| trimethylamine-N-oxide reductase [Escherichia coli O157:H7 str. EC4196],... gi\|189001277, gi... - gi\|189001277\|gb\|EDU70263.1\| trimethylamine-N-oxide reductase [Escherichia coli O157:H7 str. EC4076],... gi\|189372751, gi... - gi\|189372751\|gb\|EDU91167.1\| trimethylamine-N-oxide reductase [Escherichia coli O157:H7 str. EC869], ...	731.0	[0..1]	[847..1]
gi\|15800917, gi\|... - gi\|15800917\|ref\|NP_286933.1\| trimethylamine N-oxide reductase subunit [Escherichia coli O157:H7 EDL9... gi\|25313659 - gi\|25313659\|pir\|\|D85635 trimethylamine N-oxide reductase subunit [imported] - Escherichia coli (stra...	730.0	[0..1]	[847..1]

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Predicted Domain #1

Region A:
Residues: [1-848]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNNNDLFQAS RRRFLAQLGG LTVAGMLGPS LLTPRRATAA QAATDAVISK EGILTGSHWG  60
   61 AIRATVKDGR FVAAKPFELD KYPSKMIAGL PDHVHNAARI RYPMVRVDWL RKRHLSDTSQ 120
  121 RGDNRFVRVS WDEALDMFYE ELERVQKTHG PSALLTASGW QSTGMFHNAS GMLAKAIALH 180
  181 GNSVGTGGDY STGAAQVILP RVVGSMEVYE QQTSWPLVLQ NSKTIVLWGS DLLKNQQANW 240
  241 WCPDHDVYEY YAQLKAKVAA GEIEVISIDP VVTSTHEYLG REHVKHIAVN PQTDVPLQLA 300
  301 LAHTLYSENL YDKNFLANYC VGFEQFLPYL LGEKDGQPKD AAWAEKLTGI DAETIRGLAR 360
  361 QMAANRTQII AGWCVQRMQH GEQWAWMIVV LAAMLGQIGL PGGGFGFGWH YNGAGTPGRK 420
  421 GVILSGFSGS TSIPPVHDNS DYKGYSSTIP IARFIDAILE PGKVINWNGK SVKLPPLKMC 480
  481 IFAGTNPFHR HQQINRIIEG LRKLETVIAI DNQWTSTCRF ADIVLPATTQ FERNDLDQYG 540
  541 NHSNRGIIAM KQVVPPQFEA RNDFDIFREL CRRFNREEAF TEGLDEMGWL KRIWQEGVQQ 600
  601 GKGRGVHLPA FDDFWNNKEY VEFDHPQMFV RHQAFREDPD LEPLGTPSGL IEIYSKTIAD 660
  661 MNYDDCQGHP MWFEKIERSH GGPGSQKYPL HLQSVHPDFR LHSQLCESET LRQQYTVAGK 720
  721 EPVFINPQDA SARGIRNGDV VRVFNARGQV LAGAVVSDRY APGVARIHEG AWYDPDKGGE 780
  781 PGALCKYGNP NVLTIDIGTS QLAQATSAHT TLVEIEKYNG TVEQVTAFNG PVEMVAQCEY 840
  841 VPASQVKS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1tmoA
Description:	TRIMETHYLAMINE N-OXIDE REDUCTASE FROM SHEWANELLA MASSILIA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
trimethylamine-N-oxide reductase activity	8.75612712598998	bayes_pls_golite062009
4 iron, 4 sulfur cluster binding	6.81363258746891	bayes_pls_golite062009
formate dehydrogenase activity	6.68295624624715	bayes_pls_golite062009
metal cluster binding	5.7442724322527	bayes_pls_golite062009
iron-sulfur cluster binding	5.7442724322527	bayes_pls_golite062009
molybdenum ion binding	3.31971125919934	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor	2.54554723799271	bayes_pls_golite062009
nitrate reductase activity	2.20600951698793	bayes_pls_golite062009
catalytic activity	1.93875927205186	bayes_pls_golite062009
oxidoreductase activity	1.8662488889516	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	1.84836110501265	bayes_pls_golite062009
carbon-carbon lyase activity	1.29705810885029	bayes_pls_golite062009
carboxy-lyase activity	1.27093915206504	bayes_pls_golite062009
oxidoreductase activity, acting on other nitrogenous compounds as donors	1.12492792673137	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	0.968773059107375	bayes_pls_golite062009
lyase activity	0.603656450860878	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH	0.134493772161849	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: