YRC Public Data Repository - Protein Structure Prediction

Protein:	TKT2_ECOLI
Organism:	Escherichia coli
Length:	667 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TKT2_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|26248832, gi\|... - gi\|26248832\|ref\|NP_754872.1\| transketolase [Escherichia coli CFT073], gi\|26109238\|gb\|AAN81440.1\|AE01...	703.0	[0..1]	[667..22]
gi\|91211794, gi\|... - gi\|91211794\|ref\|YP_541780.1\| transketolase II [Escherichia coli UTI89], gi\|91073368\|gb\|ABE08249.1\| t... gi\|226901345, gi... - gi\|237704979\|ref\|ZP_04535460.1\| transketolase II [Escherichia sp. 3_2_53FAA], gi\|226901345\|gb\|EEH876...	702.0	[0..1]	[667..22]
gi\|73856467, gi\|... - gi\|74312990\|ref\|YP_311409.1\| transketolase [Shigella sonnei Ss046], gi\|73856467\|gb\|AAZ89174.1\| trans...	701.0	[0..1]	[667..1]
gi\|162138397 - gi\|162138397\|ref\|YP_541780.2\| transketolase [Escherichia coli UTI89] gi\|218366169, gi... - gi\|218559400\|ref\|YP_002392313.1\| transketolase [Escherichia coli S88], gi\|218366169\|emb\|CAR03915.1\| ... gi\|117624661, gi... - gi\|117624661\|ref\|YP_853574.1\| transketolase [Escherichia coli APEC O1], gi\|115513785\|gb\|ABJ01860.1\| ...	701.0	[0..1]	[667..1]
gi\|209763828, gi... - pir\|\|G91044 transketolase 2 isozyme [imported] - Escherichia coli (strain O157:H7, substrain RIMD 0... gi\|15832581, gi\|... - gi\|15832581\|ref\|NP_311354.1\| transketolase [Escherichia coli O157:H7 str. Sakai], gi\|13362797\|dbj\|BA... gi\|15832581, gi\|... - gi\|15832581\|ref\|NP_311354.1\| transketolase [Escherichia coli O157:H7], gi\|13362797\|dbj\|BAB36750.1\| t... gi\|217327916, gi... - gi\|217327916\|ref\|ZP_03443999.1\| transketolase [Escherichia coli O157:H7 str. TW14588], gi\|217320283\|... gi\|168798827, gi... - gi\|189378543\|gb\|EDU96959.1\| transketolase [Escherichia coli O157:H7 str. EC508], gi\|168798827\|ref\|ZP... gi\|168787802, gi... - gi\|189372349\|gb\|EDU90765.1\| transketolase [Escherichia coli O157:H7 str. EC869], gi\|168787802\|ref\|ZP... gi\|189368499, gi... - gi\|189368499\|gb\|EDU86915.1\| transketolase [Escherichia coli O157:H7 str. EC4501], gi\|168761065\|ref\|Z...	701.0	[0..1]	[667..1]
gi\|218696091, gi... - gi\|218696091\|ref\|YP_002403758.1\| transketolase [Escherichia coli 55989], gi\|218352823\|emb\|CAU98611.1... gi\|75187209, gi\|... - gi\|75187209\|ref\|ZP_00700476.1\| COG0021: Transketolase [Escherichia coli E24377A], gi\|157155048\|ref\|Y...	700.0	[0..1]	[667..1]
gi\|110642637, gi... - gi\|110642637\|ref\|YP_670367.1\| transketolase [Escherichia coli 536], gi\|110344229\|gb\|ABG70466.1\| tran... gi\|75240114, gi\|... - gi\|75240114\|ref\|ZP_00724073.1\| COG0021: Transketolase [Escherichia coli F11], gi\|191172922\|ref\|ZP_03...	699.0	[0..1]	[667..1]
gi\|75229213, gi\|... - gi\|75229213\|ref\|ZP_00715781.1\| COG0021: Transketolase [Escherichia coli B7A], gi\|191167631\|ref\|ZP_03...	699.0	[0..1]	[667..1]
gi\|193068317, gi... - gi\|75237792\|ref\|ZP_00721808.1\| COG0021: Transketolase [Escherichia coli E110019], gi\|193068317\|ref\|Z...	699.0	[0..1]	[667..1]
gi\|12516840, gi\|... - gi\|15802987\|ref\|NP_289017.1\| transketolase [Escherichia coli O157:H7 EDL933], gi\|12516840\|gb\|AAG5757... gi\|25286313 - pir\|\|B85889 transketolase 2 isozyme [imported] - Escherichia coli (strain O157:H7, substrain EDL933...	698.0	[0..1]	[667..1]

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Predicted Domain #1

Region A:
Residues: [1-667]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRKDLANAI RALSMDAVQK ANSGHPGAPM GMADIAEVLW NDFLKHNPTD PTWYDRDRFI  60
   61 LSNGHASMLL YSLLHLTGYD LPLEELKNFR QLHSKTPGHP EIGYTPGVET TTGPLGQGLA 120
  121 NAVGLAIAER TLAAQFNQPD HEIVDHFTYV FMGDGCLMEG ISHEVCSLAG TLGLGKLIGF 180
  181 YDHNGISIDG ETEGWFTDDT AKRFEAYHWH VIHEIDGHDP QAVKEAILEA QSVKDKPSLI 240
  241 ICRTVIGFGS PNKAGKEEAH GAPLGEEEVA LARQKLGWHH PPFEIPKEIY HAWDAREKGE 300
  301 KAQQSWNEKF AAYKKAHPQL AEEFTRRMSG GLPKDWEKTT QKYINELQAN PAKIATRKAS 360
  361 QNTLNAYGPM LPELLGGSAD LAPSNLTIWK GSVSLKEDPA GNYIHYGVRE FGMTAIANGI 420
  421 AHHGGFVPYT ATFLMFVEYA RNAARMAALM KARQIMVYTH DSIGLGEDGP THQAVEQLAS 480
  481 LRLTPNFSTW RPCDQVEAAV GWKLAVERHN GPTALILSRQ NLAQVERTPD QVKEIARGGY 540
  541 VLKDSGGKPD IILIATGSEM EITLQAAEKL AGEGRNVRVV SLPSTDIFDA QDEEYRESVL 600
  601 PSNVAARVAV EAGIADYWYK YVGLKGAIVG MTGYGESAPA DKLFPFFGFT AENIVAKAHK 660
  661 VLGVKGA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1qgdA
Description:	Transketolase (TK), Pyr module; Transketolase (TK), PP module; Transketolase (TK), C-domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transketolase activity	6.17852985073866	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	2.93250853993668	bayes_pls_golite062009
pyruvate dehydrogenase activity	2.81702263447118	bayes_pls_golite062009
pyruvate dehydrogenase (acetyl-transferring) activity	2.6977837113283	bayes_pls_golite062009
transferase activity, transferring aldehyde or ketonic groups	2.21959520697519	bayes_pls_golite062009
binding	0.980920092099572	bayes_pls_golite062009
catalytic activity	0.545407789079971	bayes_pls_golite062009
thiamin pyrophosphate binding	0.297191393111081	bayes_pls_golite062009
acetolactate synthase activity	0.173822256668691	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: