YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|16648464, gi\|...
Organism:	Drosophila melanogaster
Length:	114 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|16648464, gi|....

Description	E-value	Query Range	Subject Range
gi\|76812139, gi\|... - gi\|76812139\|ref\|YP_333769.1\| thioredoxin 1 [Burkholderia pseudomallei 1710b], gi\|76581592\|gb\|ABA5106...	148.0	[0..8]	[114..40]
gi\|83721362, gi\|... - gi\|83721362\|ref\|YP_442739.1\| thioredoxin [Burkholderia thailandensis E264], gi\|83655187\|gb\|ABC39250....	146.0	[0..8]	[114..40]
gi\|25067747 - gi\|25067747\|gb\|AAN65341.1\| thioredoxin/transketolase fusion protein [synthetic construct]	146.0	[0..8]	[114..2]
gi\|160872103, gi... - gi\|94494048\|ref\|ZP_01301251.1\| hypothetical protein Rgryl_01000578 [Rickettsiella grylli], gi\|160872...	145.0	[0..7]	[114..2]
gi\|110593092, gi... - gi\|110593092\|ref\|ZP_01381446.1\| thioredoxin [Acidovorax sp. JS42], gi\|110337599\|gb\|EAT57311.1\| thior...	144.0	[0..7]	[114..23]
gi\|95928472, gi\|... - gi\|95928472\|ref\|ZP_01311219.1\| thioredoxin [Desulfuromonas acetoxidans DSM 684], gi\|95135262\|gb\|EAT1...	144.0	[0..7]	[114..2]
gi\|25282752 - pir\|\|AD0471 thioredoxin 1 [imported] - Yersinia pestis (strain CO92) gi\|45437796, gi\|... - gi\|45442929\|ref\|NP_994468.1\| thioredoxin 1 [Yersinia pestis biovar Microtus str. 91001], gi\|45437796... gi\|21957044, gi\|... - gi\|22124275\|ref\|NP_667698.1\| thioredoxin 1 [Yersinia pestis KIM], gi\|21957044\|gb\|AAM83949.1\|AE013636... gi\|149289382, gi... - gi\|153997076\|ref\|ZP_02022209.1\| thioredoxin 1 [Yersinia pestis CA88-4125], gi\|149289382\|gb\|EDM39460.... gi\|15981783, gi\|... - gi\|218930871\|ref\|YP_002348746.1\| thioredoxin 1 [Yersinia pestis CO92], gi\|16124003\|ref\|NP_407316.1\| ... gi\|167055055, gi... - gi\|167425907\|ref\|ZP_02317660.1\| thioredoxin [Yersinia pestis biovar Mediaevalis str. K1973002], gi\|1... gi\|51587804, gi\|... - gi\|51594522\|ref\|YP_068713.1\| thioredoxin 1 [Yersinia pseudotuberculosis IP 32953], gi\|51587804\|emb\|C... gi\|167420843, gi... - gi\|167420843\|ref\|ZP_02312596.1\| thioredoxin [Yersinia pestis biovar Orientalis str. MG05-1020], gi\|1... gi\|186893520, gi... - gi\|186893520\|ref\|YP_001870632.1\| thioredoxin [Yersinia pseudotuberculosis PB1/+], gi\|186696546\|gb\|AC... gi\|169752779, gi... - gi\|170026245\|ref\|YP_001722750.1\| thioredoxin [Yersinia pseudotuberculosis YPIII], gi\|169752779\|gb\|AC... gi\|89103427, gi\|... - gi\|89103427\|ref\|ZP_01176005.1\| COG0526: Thiol-disulfide isomerase and thioredoxins [Yersinia pestis ... Q66G18\|Q66G18_YERPS - Thioredoxin 1 - Yersinia pseudotuberculosis gi\|108806148, gi... - gi\|108806148\|ref\|YP_650064.1\| thioredoxin 1 [Yersinia pestis Antiqua], gi\|108778061\|gb\|ABG12119.1\| t... gi\|229682448, gi... - gi\|229900429\|ref\|ZP_04515558.1\| thioredoxin 1 [Yersinia pestis Nepal516], gi\|229682448\|gb\|EEO78535.1... gi\|229837201, gi... - gi\|229837201\|ref\|ZP_04457366.1\| thioredoxin 1 [Yersinia pestis Pestoides A], gi\|229706144\|gb\|EEO9215... gi\|229695927, gi... - gi\|229839561\|ref\|ZP_04459720.1\| thioredoxin 1 [Yersinia pestis biovar Orientalis str. PEXU2], gi\|229... gi\|229686904, gi... - gi\|229900124\|ref\|ZP_04515261.1\| thioredoxin 1 [Yersinia pestis biovar Orientalis str. India 195], gi... gi\|166009693, gi... - gi\|166009693\|ref\|ZP_02230591.1\| thioredoxin [Yersinia pestis biovar Antiqua str. E1979001], gi\|16599... gi\|165921813, gi... - gi\|165926289\|ref\|ZP_02222121.1\| thioredoxin [Yersinia pestis biovar Orientalis str. F1991016], gi\|16... gi\|167402076, gi... - gi\|167402076\|ref\|ZP_02307555.1\| thioredoxin [Yersinia pestis biovar Antiqua str. UG05-0454], gi\|1670... gi\|166205236, gi... - gi\|166213563\|ref\|ZP_02239598.1\| thioredoxin [Yersinia pestis biovar Antiqua str. B42003004], gi\|1662... gi\|162354023, gi... - gi\|77634499\|ref\|ZP_00796598.1\| COG0526: Thiol-disulfide isomerase and thioredoxins [Yersinia pestis ... gi\|152961526, gi... - gi\|77630765\|ref\|ZP_00793351.1\| COG0526: Thiol-disulfide isomerase and thioredoxins [Yersinia pseudot...	144.0	[0..8]	[114..2]
gi\|116057647 - gi\|116057647\|emb\|CAL53850.1\| Thioredoxin (ISS) [Ostreococcus tauri]	144.0	[0..7]	[114..109]
gi\|575449 - gi\|575449\|gb\|AAA67270.1\| Derived from E. coli thioredoxin gene; normal translation termination codon...	143.0	[0..8]	[114..2]
gi\|238789357, gi... - gi\|77972622\|ref\|ZP_00828183.1\| COG0526: Thiol-disulfide isomerase and thioredoxins [Yersinia frederi...	143.0	[0..8]	[114..2]

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Predicted Domain #1

Region A:
Residues: [1-114]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMILLRDSTN LHFHLQADLD GQLTKASGKL VVLDFFATWC GPCKMISPKL VELSTQFADN  60
   61 VVVLKVDVDE CEDIAMEYNI SSMPTFVFLK NGVKVEEFAG ANAKRLEDVI KANI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	28.522879
Match:	1xwaA
Description:	Drospohila thioredoxin, oxidized, P41212
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
antioxidant activity	3.66884588063322	bayes_pls_golite062009
peroxidase activity	3.43831566988273	bayes_pls_golite062009
oxidoreductase activity, acting on peroxide as acceptor	3.43831566988273	bayes_pls_golite062009
glutathione peroxidase activity	2.56524997297011	bayes_pls_golite062009
intramolecular oxidoreductase activity, transposing S-S bonds	2.3913606099687	bayes_pls_golite062009
protein disulfide isomerase activity	2.3913606099687	bayes_pls_golite062009
protein-disulfide reductase activity	2.24066563461479	bayes_pls_golite062009
intramolecular oxidoreductase activity, interconverting keto- and enol-groups	2.18667085747706	bayes_pls_golite062009
peroxiredoxin activity	2.12777217096121	bayes_pls_golite062009
thioredoxin peroxidase activity	1.96134566495756	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	1.8187537496904	bayes_pls_golite062009
disulfide oxidoreductase activity	1.32811008894503	bayes_pls_golite062009
binding	1.25802922431343	bayes_pls_golite062009
transcription regulator activity	0.96297634785608	bayes_pls_golite062009
catalytic activity	0.672192331361968	bayes_pls_golite062009
hydrolase activity	0.620302638089385	bayes_pls_golite062009
protein disulfide oxidoreductase activity	0.44918717550973	bayes_pls_golite062009
glutathione binding	0.2456976890622	bayes_pls_golite062009
transferase activity	0.245320538630117	bayes_pls_golite062009
protein binding	0.134341907247724	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: