YRC Public Data Repository - Protein Structure Prediction

Protein:	THD1_ECOLI
Organism:	Escherichia coli
Length:	514 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for THD1_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|90413761, gi\|... - gi\|90413761\|ref\|ZP_01221749.1\| threonine dehydratase [Photobacterium profundum 3TCK], gi\|90325230\|gb...	605.0	[0..1]	[513..1]
gi\|146452 - gi\|146452\|gb\|AAA24014.1\| threonine dehydratase [Escherichia coli]	605.0	[0..1]	[514..1]
gi\|54310634, gi\|... - gi\|54310634\|ref\|YP_131654.1\| threonine dehydratase [Photobacterium profundum SS9], gi\|46915077\|emb\|C...	602.0	[0..1]	[513..1]
gi\|152989630, gi... - gi\|94414836\|ref\|ZP_01294690.1\| hypothetical protein PaerP_01003416 [Pseudomonas aeruginosa PA7], gi\|...	599.0	[0..14]	[513..3]
gi\|116185038 - gi\|116185038\|ref\|ZP_01474957.1\| hypothetical protein VEx2w_02002438 [Vibrio sp. Ex25]	597.0	[0..11]	[513..11]
gi\|28899836, gi\|... - gi\|28899836\|ref\|NP_799441.1\| threonine dehydratase [Vibrio parahaemolyticus RIMD 2210633], gi\|288080... gi\|28808088 - gi\|28808088\|dbj\|BAC61325.1\| threonine dehydratase [Vibrio parahaemolyticus RIMD 2210633]	596.0	[0..1]	[513..1]
gi\|87281645, gi\|... - gi\|87303848\|ref\|ZP_01086553.1\| threonine dehydratase [Synechococcus sp. WH 5701], gi\|87281645\|gb\|EAQ...	595.0	[0..13]	[513..2]
gi\|27364461, gi\|... - gi\|27364461\|ref\|NP_759989.1\| threonine dehydratase [Vibrio vulnificus CMCP6], gi\|27360580\|gb\|AAO0951...	595.0	[0..1]	[513..1]
gi\|218889072, gi... - gi\|218889072\|ref\|YP_002437936.1\| threonine dehydratase [Pseudomonas aeruginosa LESB58], gi\|218769295... gi\|11352637 - pir\|\|F83603 threonine dehydratase, biosynthetic PA0331 [imported] - Pseudomonas aeruginosa (strain P... gi\|254237434, gi... - gi\|84318487\|ref\|ZP_00966910.1\| COG1171: Threonine dehydratase [Pseudomonas aeruginosa C3719], gi\|254... gi\|254243429, gi... - gi\|84324414\|ref\|ZP_00972472.1\| COG1171: Threonine dehydratase [Pseudomonas aeruginosa 2192], gi\|2542... gi\|15595528, gi\|... - gi\|9946179\|gb\|AAG03720.1\|AE004471_3 threonine dehydratase, biosynthetic [Pseudomonas aeruginosa PAO1... gi\|107099314 - gi\|107099314\|ref\|ZP_01363232.1\| hypothetical protein PaerPA_01000326 [Pseudomonas aeruginosa PACS2]	595.0	[0..14]	[513..3]
gi\|116054058, gi... - gi\|53727080\|ref\|ZP_00140763.2\| COG1171: Threonine dehydratase [Pseudomonas aeruginosa UCBPP-PA14], g...	594.0	[0..14]	[513..3]

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Predicted Domain #1

Region A:
Residues: [1-514]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADSQPLSGA PEGAEYLRAV LRAPVYEAAQ VTPLQKMEKL SSRLDNVILV KREDRQPVHS  60
   61 FKLRGAYAMM AGLTEEQKAH GVITASAGNH AQGVAFSSAR LGVKALIVMP TATADIKVDA 120
  121 VRGFGGEVLL HGANFDEAKA KAIELSQQQG FTWVPPFDHP MVIAGQGTLA LELLQQDAHL 180
  181 DRVFVPVGGG GLAAGVAVLI KQLMPQIKVI AVEAEDSACL KAALDAGHPV DLPRVGLFAE 240
  241 GVAVKRIGDE TFRLCQEYLD DIITVDSDAI CAAMKDLFED VRAVAEPSGA LALAGMKKYI 300
  301 ALHNIRGERL AHILSGANVN FHGLRYVSER CELGEQREAL LAVTIPEEKG SFLKFCQLLG 360
  361 GRSVTEFNYR FADAKNACIF VGVRLSRGLE ERKEILQMLN DGGYSVVDLS DDEMAKLHVR 420
  421 YMVGGRPSHP LQERLYSFEF PESPGALLRF LNTLGTYWNI SLFHYRSHGT DYGRVLAAFE 480
  481 LGDHEPDFET RLNELGYDCH DETNNPAFRF FLAG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	168.0
Match:	1tdjA
Description:	THREONINE DEAMINASE (BIOSYNTHETIC) FROM E. COLI
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
acetolactate synthase activity	6.50887202511626	bayes_pls_golite062009
transferase activity, transferring aldehyde or ketonic groups	5.28856942236052	bayes_pls_golite062009
threonine racemase activity	4.44340924206787	bayes_pls_golite062009
threonine synthase activity	3.59927532963055	bayes_pls_golite062009
cysteine synthase activity	3.57860549303214	bayes_pls_golite062009
L-threonine ammonia-lyase activity	3.33109959091277	bayes_pls_golite062009
carbon-oxygen lyase activity, acting on phosphates	2.61572425646119	bayes_pls_golite062009
tryptophan synthase activity	1.99526226543975	bayes_pls_golite062009
lyase activity	1.87743897464083	bayes_pls_golite062009
binding	1.14906798355281	bayes_pls_golite062009
carbon-oxygen lyase activity	0.923824749425553	bayes_pls_golite062009
catalytic activity	0.645256181736122	bayes_pls_golite062009
ammonia-lyase activity	0.476674617721478	bayes_pls_golite062009
protein binding	0.341967829237094	bayes_pls_golite062009
carbon-nitrogen lyase activity	0.249761226675912	bayes_pls_golite062009
transcription regulator activity	0.248470717905239	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: