YRC Public Data Repository - Protein Structure Prediction

Protein:	TDCC_ECOLI
Organism:	Escherichia coli
Length:	443 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TDCC_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|68373624 - gi\|68373624\|ref\|XP_692242.1\| PREDICTED: similar to Cationic amino acid transporter 3 (CAT-3) (Solute...	214.0	[0..12]	[410..970]
gi\|91084137 - gi\|91084137\|ref\|XP_969912.1\| PREDICTED: similar to CG8475-PA, isoform A [Tribolium castaneum]	211.0	[0..12]	[410..2474]
gi\|238482071, gi... - gi\|238482071\|ref\|XP_002372274.1\| amino acid permease (Gap1), putative [Aspergillus flavus NRRL3357],... gi\|169765514 - gi\|169765514\|ref\|XP_001817228.1\| hypothetical protein [Aspergillus oryzae RIB40] gi\|83765083 - gi\|83765083\|dbj\|BAE55226.1\| unnamed protein product [Aspergillus oryzae]	200.0	[0..2]	[443..65]
gi\|116181860, gi... - gi\|88185855\|gb\|EAQ93323.1\| hypothetical protein CHGG_01558 [Chaetomium globosum CBS 148.51], gi\|1161...	196.0	[0..6]	[421..100]
gi\|47221082 - gi\|47221082\|emb\|CAG12776.1\| unnamed protein product [Tetraodon nigroviridis]	195.0	[0..9]	[425..15]
gi\|42547995, gi\|... - gi\|46115914\|ref\|XP_383975.1\| hypothetical protein FG03799.1 [Gibberella zeae PH-1], gi\|42547995\|gb\|E...	192.0	[0..6]	[442..106]
gi\|85095443 - gi\|85095443\|ref\|XP_960090.1\| general amino-acid permease GAP1 [Neurospora crassa OR74A] gi\|32410409, gi\|... - gi\|32410409\|ref\|XP_325685.1\| hypothetical protein [Neurospora crassa], gi\|28921549\|gb\|EAA30854.1\| ge...	192.0	[0..9]	[440..139]
gi\|114193057, gi... - gi\|115395202\|ref\|XP_001213488.1\| general amino-acid permease GAP1 [Aspergillus terreus NIH2624], gi\|...	189.0	[0..2]	[443..63]
gi\|49647803, gi\|... - gi\|50548931\|ref\|XP_501936.1\| YALI0C17237p [Yarrowia lipolytica], gi\|49647803\|emb\|CAG82256.1\| unnamed... gi\|49647803 - gi\|49647803\|emb\|CAG82256.1\| YALI0C17237p [Yarrowia lipolytica]	189.0	[0..6]	[443..97]
GNP1_YEAST - High-affinity glutamine permease OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GNP1 PE... GNP1 - High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn; expression is ful...	188.0	[0..3]	[442..133]

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Predicted Domain #1

Region A:
Residues: [1-443]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTSDSIVSS QTKQSSWRKS DTTWTLGLFG TAIGAGVLFF PIRAGFGGLI PILLMLVLAY  60
   61 PIAFYCHRAL ARLCLSGSNP SGNITETVEE HFGKTGGVVI TFLYFFAICP LLWIYGVTIT 120
  121 NTFMTFWENQ LGFAPLNRGF VALFLLLLMA FVIWFGKDLM VKVMSYLVWP FIASLVLISL 180
  181 SLIPYWNSAV IDQVDLGSLS LTGHDGILIT VWLGISIMVF SFNFSPIVSS FVVSKREEYE 240
  241 KDFGRDFTER KCSQIISRAS MLMVAVVMFF AFSCLFTLSP ANMAEAKAQN IPVLSYLANH 300
  301 FASMTGTKTT FAITLEYAAS IIALVAIFKS FFGHYLGTLE GLNGLVLKFG YKGDKTKVSL 360
  361 GKLNTISMIF IMGSTWVVAY ANPNILDLIE AMGAPIIASL LCLLPMYAIR KAPSLAKYRG 420
  421 RLDNVFVTVI GLLTILNIVY KLF

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.3
Match:	2a65A
Description:	Crystal structure of LEUTAA, a bacterial homolog of Na+/Cl--dependent neurotransmitter transporters
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
amine transmembrane transporter activity	5.15069657292327	bayes_pls_golite062009
amino acid transmembrane transporter activity	4.54752581624334	bayes_pls_golite062009
carboxylic acid transmembrane transporter activity	4.39427743642027	bayes_pls_golite062009
organic acid transmembrane transporter activity	4.356142166703	bayes_pls_golite062009
neutral amino acid transmembrane transporter activity	4.15945726490058	bayes_pls_golite062009
transporter activity	3.46503611631839	bayes_pls_golite062009
transmembrane transporter activity	3.34431027577801	bayes_pls_golite062009
substrate-specific transporter activity	3.08398439124803	bayes_pls_golite062009
active transmembrane transporter activity	2.98812190037621	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	2.96577701947757	bayes_pls_golite062009
ion transmembrane transporter activity	1.89542769737674	bayes_pls_golite062009
organic acid:sodium symporter activity	1.82263833070018	bayes_pls_golite062009
L-amino acid transmembrane transporter activity	1.79964917042361	bayes_pls_golite062009
cation transmembrane transporter activity	1.79923665576923	bayes_pls_golite062009
glycine transmembrane transporter activity	1.75790579341195	bayes_pls_golite062009
monoamine transmembrane transporter activity	1.59349600647168	bayes_pls_golite062009
secondary active transmembrane transporter activity	1.37015067735708	bayes_pls_golite062009
symporter activity	1.31198147603118	bayes_pls_golite062009
solute:cation symporter activity	1.31198147603118	bayes_pls_golite062009
solute:sodium symporter activity	0.868753445363102	bayes_pls_golite062009
neurotransmitter:sodium symporter activity	0.658077875061275	bayes_pls_golite062009
binding	0.299468111884938	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: