YRC Public Data Repository - Protein Structure Prediction

Protein:	PYRF_ECOLI
Organism:	Escherichia coli
Length:	245 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PYRF_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|238794724, gi... - gi\|77977460\|ref\|ZP_00832908.1\| COG0284: Orotidine-5'-phosphate decarboxylase [Yersinia intermedia AT...	235.0	[0..1]	[245..1]
gi\|77960384 - gi\|77960384\|ref\|ZP_00824258.1\| COG0284: Orotidine-5'-phosphate decarboxylase [Yersinia mollaretii AT...	232.0	[0..1]	[245..1]
gi\|116187749, gi... - gi\|75828740\|ref\|ZP_00758086.1\| COG0284: Orotidine-5'-phosphate decarboxylase [Vibrio cholerae MO10],... gi\|229351734, gi... - gi\|229511769\|ref\|ZP_04401248.1\| orotidine 5'-phosphate decarboxylase [Vibrio cholerae B33], gi\|22935... gi\|121630524, gi... - gi\|75816131\|ref\|ZP_00746610.1\| COG0284: Orotidine-5'-phosphate decarboxylase [Vibrio cholerae V52], ... PYRF_VIBCM - Orotidine 5'-phosphate decarboxylase OS=Vibrio cholerae serotype O1 (strain M66-2) GN=pyrF PE=3 SV=1 gi\|229507993, gi... - gi\|229507993\|ref\|ZP_04397498.1\| orotidine 5'-phosphate decarboxylase [Vibrio cholerae BX 330286], gi... gi\|229518907, gi... - gi\|229518907\|ref\|ZP_04408350.1\| orotidine 5'-phosphate decarboxylase [Vibrio cholerae RC9], gi\|22934... gi\|229607539, gi... - gi\|229607539\|ref\|YP_002878187.1\| orotidine 5'-phosphate decarboxylase [Vibrio cholerae MJ-1236], gi\|... PYRF_VIBCH - Orotidine 5'-phosphate decarboxylase OS=Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inab... PYRF_VIBCH - Orotidine 5'-phosphate decarboxylase OS=Vibrio cholerae GN=pyrF PE=1 SV=1 gi\|121546724, gi... - gi\|121591429\|ref\|ZP_01678708.1\| orotidine 5`-phosphate decarboxylase [Vibrio cholerae 2740-80], gi\|1... gi\|153225057, gi... - gi\|153225057\|ref\|ZP_01954684.1\| orotidine 5`-phosphate decarboxylase [Vibrio cholerae MAK 757], gi\|1... gi\|153819859, gi... - gi\|153819859\|ref\|ZP_01972526.1\| orotidine 5`-phosphate decarboxylase [Vibrio cholerae NCTC 8457], gi...	232.0	[0..12]	[241..1]
PYRF_VIBF1 - Orotidine 5'-phosphate decarboxylase OS=Vibrio fischeri (strain ATCC 700601 / ES114) GN=pyrF PE=3 SV... PYRF_VIBFM - Orotidine 5'-phosphate decarboxylase OS=Vibrio fischeri (strain MJ11) GN=pyrF PE=3 SV=1	232.0	[0..12]	[244..1]
PYRF_SHIDS - Orotidine 5'-phosphate decarboxylase OS=Shigella dysenteriae serotype 1 (strain Sd197) GN=pyrF PE=3 ...	232.0	[0..1]	[245..1]
PYRF_VIBC3 - Orotidine 5'-phosphate decarboxylase OS=Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical O...	232.0	[0..12]	[241..1]
gi\|69156212, gi\|... - gi\|91793113\|ref\|YP_562764.1\| orotidine 5'-phosphate decarboxylase [Shewanella denitrificans OS217], ...	231.0	[0..12]	[241..1]
gi\|83569498 - gi\|83569498\|ref\|ZP_00920951.1\| COG0284: Orotidine-5'-phosphate decarboxylase [Shigella dysenteriae 1...	231.0	[0..1]	[245..21]
PYRF_YERP3 - Orotidine 5'-phosphate decarboxylase OS=Yersinia pseudotuberculosis serotype O:1b (strain IP 31758) ... PYRF_YERPS - Orotidine 5'-phosphate decarboxylase OS=Yersinia pseudotuberculosis GN=pyrF PE=3 SV=1 PYRF_YERPB - Orotidine 5'-phosphate decarboxylase OS=Yersinia pseudotuberculosis serotype IB (strain PB1/+) GN=py... PYRF_YERPS - Orotidine 5'-phosphate decarboxylase OS=Yersinia pseudotuberculosis serotype I (strain IP32953) GN=p...	230.0	[0..1]	[245..1]
PYRF_SHIF8 - Orotidine 5'-phosphate decarboxylase OS=Shigella flexneri serotype 5b (strain 8401) GN=pyrF PE=3 SV=...	230.0	[0..1]	[245..1]

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Predicted Domain #1

Region A:
Residues: [1-245]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTLTASSSSR AVTNSPVVVA LDYHNRDDAL AFVDKIDPRD CRLKVGKEMF TLFGPQFVRE  60
   61 LQQRGFDIFL DLKFHDIPNT AAHAVAAAAD LGVWMVNVHA SGGARMMTAA REALVPFGKD 120
  121 APLLIAVTVL TSMEASDLVD LGMTLSPADY AERLAALTQK CGLDGVVCSA QEAVRFKQVF 180
  181 GQEFKLVTPG IRPQGSEAGD QRRIMTPEQA LSAGVDYMVI GRPVTQSVDP AQTLKAINAS 240
  241 LQRSA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	60.30103
Match:	1eixA
Description:	Orotidine 5'-monophosphate decarboxylase (OMP decarboxylase)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
orotidine-5'-phosphate decarboxylase activity	2.87717797280068	bayes_pls_golite062009
catalytic activity	2.44231061702877	bayes_pls_golite062009
ribulose-phosphate 3-epimerase activity	0.982517927791965	bayes_pls_golite062009
carboxy-lyase activity	0.83446736141993	bayes_pls_golite062009
orotate phosphoribosyltransferase activity	0.108467338662618	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: