YRC Public Data Repository - Protein Structure Prediction

Protein:	PHR_ECOLI
Organism:	Escherichia coli
Length:	472 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PHR_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|81244548, gi\|... - gi\|82543137\|ref\|YP_407084.1\| deoxyribodipyrimidine photolyase [Shigella boydii Sb227], gi\|81244548\|g...	482.0	[0..1]	[471..1]
gi\|187734160, gi... - gi\|75175907\|ref\|ZP_00696094.1\| COG0415: Deoxyribodipyrimidine photolyase [Shigella boydii BS512], gi...	481.0	[0..1]	[471..1]
gi\|75234514, gi\|... - gi\|75234514\|ref\|ZP_00718861.1\| COG0415: Deoxyribodipyrimidine photolyase [Escherichia coli E110019],...	481.0	[0..1]	[471..1]
gi\|75189729, gi\|... - gi\|75189729\|ref\|ZP_00702996.1\| COG0415: Deoxyribodipyrimidine photolyase [Escherichia coli E24377A],... gi\|218553235, gi... - gi\|218553235\|ref\|YP_002386148.1\| deoxyribodipyrimidine photolyase [Escherichia coli IAI1], gi\|218360... gi\|218350863, gi... - gi\|218694131\|ref\|YP_002401798.1\| deoxyribodipyrimidine photolyase [Escherichia coli 55989], gi\|21835...	481.0	[0..1]	[471..1]
gi\|191167217, gi... - gi\|75229659\|ref\|ZP_00716196.1\| COG0415: Deoxyribodipyrimidine photolyase [Escherichia coli B7A], gi\|...	480.0	[0..1]	[471..1]
gi\|73854708, gi\|... - gi\|74311231\|ref\|YP_309650.1\| deoxyribodipyrimidine photolyase [Shigella sonnei Ss046], gi\|73854708\|g...	479.0	[0..1]	[472..1]
gi\|192926843, gi... - gi\|75256417\|ref\|ZP_00728075.1\| COG0415: Deoxyribodipyrimidine photolyase [Escherichia coli E22], gi\|... gi\|75209724, gi\|... - gi\|75209724\|ref\|ZP_00709932.1\| COG0415: Deoxyribodipyrimidine photolyase [Escherichia coli B171], gi...	479.0	[0..1]	[471..1]
gi\|209776598, gi... - pir\|\|E90720 deoxyribodipyrimidine photolyase [imported] - Escherichia coli (strain O157:H7, substrai... gi\|15829987, gi\|... - gi\|15829987\|ref\|NP_308760.1\| deoxyribodipyrimidine photolyase [Escherichia coli O157:H7], gi\|1336019... gi\|254791854, gi... - gi\|254791854\|ref\|YP_003076691.1\| deoxyribodipyrimidine photolyase, FAD-binding [Escherichia coli O15... gi\|188015195, gi... - gi\|188015195\|gb\|EDU53317.1\| deoxyribodipyrimidine photolyase [Escherichia coli O157:H7 str. EC4113],... gi\|217325709, gi... - gi\|217325709\|ref\|ZP_03441793.1\| deoxyribodipyrimidine photolyase [Escherichia coli O157:H7 str. TW14... gi\|208729447, gi... - gi\|208809646\|ref\|ZP_03251983.1\| deoxyribodipyrimidine photolyase [Escherichia coli O157:H7 str. EC42... gi\|208732151, gi... - gi\|208815503\|ref\|ZP_03256682.1\| deoxyribodipyrimidine photolyase [Escherichia coli O157:H7 str. EC40... gi\|208737170, gi... - gi\|208822977\|ref\|ZP_03263295.1\| deoxyribodipyrimidine photolyase [Escherichia coli O157:H7 str. EC40... gi\|209397896, gi... - gi\|209397896\|ref\|YP_002269331.1\| deoxyribodipyrimidine photolyase [Escherichia coli O157:H7 str. EC4... gi\|168779189, gi... - gi\|189003074\|gb\|EDU72060.1\| deoxyribodipyrimidine photolyase [Escherichia coli O157:H7 str. EC4076],... gi\|168786859, gi... - gi\|189373172\|gb\|EDU91588.1\| deoxyribodipyrimidine photolyase [Escherichia coli O157:H7 str. EC869], ... gi\|189376468, gi... - gi\|189376468\|gb\|EDU94884.1\| deoxyribodipyrimidine photolyase [Escherichia coli O157:H7 str. EC508], ... gi\|195939049 - gi\|195939049\|ref\|ZP_03084431.1\| deoxyribodipyrimidine photolyase [Escherichia coli O157:H7 str. EC40... gi\|15829987, gi\|... - gi\|15829987\|ref\|NP_308760.1\| deoxyribodipyrimidine photolyase [Escherichia coli O157:H7 str. Sakai],... gi\|189355803, gi... - gi\|189355803\|gb\|EDU74222.1\| deoxyribodipyrimidine photolyase [Escherichia coli O157:H7 str. EC4401],... gi\|168763986, gi... - gi\|189365922\|gb\|EDU84338.1\| deoxyribodipyrimidine photolyase [Escherichia coli O157:H7 str. EC4501],... gi\|189363333, gi... - gi\|189363333\|gb\|EDU81752.1\| deoxyribodipyrimidine photolyase [Escherichia coli O157:H7 str. EC4486],... gi\|168777031, gi... - gi\|187767666\|gb\|EDU31510.1\| deoxyribodipyrimidine photolyase [Escherichia coli O157:H7 str. EC4196],...	478.0	[0..1]	[472..1]
gi\|25291448 - pir\|\|C85571 hypothetical protein phrB [imported] - Escherichia coli (strain O157:H7, substrain EDL9... gi\|12513619, gi\|... - gi\|15800411\|ref\|NP_286423.1\| deoxyribodipyrimidine photolyase [Escherichia coli O157:H7 EDL933], gi\|...	478.0	[0..1]	[472..1]
gi\|254287566, gi... - gi\|254287566\|ref\|YP_003053314.1\| deoxyribodipyrimidine photolyase, FAD-binding [Escherichia coli BL2... gi\|254160778, gi... - gi\|254160778\|ref\|YP_003043886.1\| deoxyribodipyrimidine photolyase, FAD-binding [Escherichia coli B s... gi\|194421838, gi... - gi\|83585360\|ref\|ZP_00924007.1\| COG0415: Deoxyribodipyrimidine photolyase [Escherichia coli 101-1], g...	477.0	[0..1]	[471..1]

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Predicted Domain #1

Region A:
Residues: [1-472]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTHLVWFRQ DLRLHDNLAL AAACRNSSAR VLALYIATPR QWATHNMSPR QAELINAQLN  60
   61 GLQIALAEKG IPLLFREVDD FVASVEIVKQ VCAENSVTHL FYNYQYEVNE RARDVEVERA 120
  121 LRNVVCEGFD DSVILPPGAV MTGNHEMYKV FTPFKNAWLK RLREGMPECV AAPKVRSSGS 180
  181 IEPSPSITLN YPRQSFDTAH FPVEEKAAIA QLRQFCQNGA GEYEQQRDFP AVEGTSRLSA 240
  241 SLATGGLSPR QCLHRLLAEQ PQALDGGAGS VWLNELIWRE FYRHLITYHP SLCKHRPFIA 300
  301 WTDRVQWQSN PAHLQAWQEG KTGYPIVDAA MRQLNSTGWM HNRLRMITAS FLVKDLLIDW 360
  361 REGERYFMSQ LIDGDLAANN GGWQWAASTG TDAAPYFRIF NPTTQGEKFD HEGEFIRQWL 420
  421 PELRDVPGKV VHEPWKWAQK AGVTLDYPQP IVEHKEARVQ TLAAYEAARK GK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	135.0
Match:	1dnpA
Description:	C-terminal domain of DNA photolyase; DNA photolyase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
blue light photoreceptor activity	9.1431674572348	bayes_pls_golite062009
photoreceptor activity	8.36697703010092	bayes_pls_golite062009
DNA photolyase activity	5.59238172310626	bayes_pls_golite062009
transcription repressor activity	4.08500855631983	bayes_pls_golite062009
transcription regulator activity	3.49617875539388	bayes_pls_golite062009
nucleic acid binding	2.19167058827256	bayes_pls_golite062009
binding	2.13238451443633	bayes_pls_golite062009
G-protein coupled photoreceptor activity	2.1101484978621	bayes_pls_golite062009
DNA binding	2.05514577638135	bayes_pls_golite062009
deoxyribodipyrimidine photo-lyase activity	2.01343813518186	bayes_pls_golite062009
FAD binding	1.81559602758107	bayes_pls_golite062009
catalytic activity	0.609980967042895	bayes_pls_golite062009
damaged DNA binding	0.5555984473366	bayes_pls_golite062009
protein binding	0.452275661161724	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: