YRC Public Data Repository - Protein Structure Prediction

Protein:	PAAG_ECOLI
Organism:	Escherichia coli
Length:	262 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PAAG_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|20807045, gi\|... - gi\|20807045\|ref\|NP_622216.1\| 3-hydroxybutyryl-CoA dehydratase [Thermoanaerobacter tengcongensis MB4]... gi\|20807045 - gi\|20807045\|ref\|NP_622216.1\| enoyl-CoA hydratase [Thermoanaerobacter tengcongensis MB4]	304.0	[0..2]	[262..3]
gi\|241218800, gi... - gi\|241769557\|ref\|ZP_04766976.1\| Enoyl-CoA hydratase/isomerase [Sulfolobus solfataricus 98/2], gi\|241... gi\|25291790 - pir\|\|A90436 enoyl CoA hydratase (paaF-7) [imported] - Sulfolobus solfataricus gi\|13815932, gi\|... - gi\|15899349\|ref\|NP_343954.1\| enoyl CoA hydratase (paaF-7) [Sulfolobus solfataricus P2], gi\|13815932\|...	303.0	[0..1]	[261..8]
gi\|70606884, gi\|... - gi\|70606884\|ref\|YP_255754.1\| 3-hydroxybutyryl-CoA dehydrogenase [Sulfolobus acidocaldarius DSM 639],...	298.0	[0..4]	[262..410]
gi\|15920248, gi\|... - gi\|15920248\|ref\|NP_375917.1\| 3-hydroxybutyryl-CoA dehydrogenase [Sulfolobus tokodaii str. 7], gi\|156...	297.0	[0..4]	[262..399]
gi\|28204455, gi\|... - gi\|28212012\|ref\|NP_782956.1\| 3-hydroxybutyryl-CoA dehydratase [Clostridium tetani E88], gi\|28204455\|...	295.0	[0..4]	[262..5]
gi\|88926146, gi\|... - gi\|88944140\|ref\|ZP_01147473.1\| putative crotonase [Desulfotomaculum reducens MI-1], gi\|88926146\|gb\|E...	295.0	[0..4]	[262..5]
gi\|77997022, gi\|... - gi\|78044907\|ref\|YP_360429.1\| 3-hydroxybutyryl-CoA dehydratase [Carboxydothermus hydrogenoformans Z-2...	295.0	[0..2]	[262..3]
gi\|116062799, gi... - gi\|118431474\|ref\|NP_147973.2\| 3-hydroxyacyl-CoA dehydrogenase/3-hydroxybutyryl-CoA dehydratase [Aero...	292.0	[0..2]	[262..413]

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Predicted Domain #1

Region A:
Residues: [1-262]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMEFILSHVE KGVMTLTLNR PERLNSFNDE MHAQLAECLK QVERDDTIRC LLLTGAGRGF  60
   61 CAGQDLNDRN VDPTGPAPDL GMSVERFYNP LVRRLAKLPK PVICAVNGVA AGAGATLALG 120
  121 GDIVIAARSA KFVMAFSKLG LIPDCGGTWL LPRVAGRARA MGLALLGNQL SAEQAHEWGM 180
  181 IWQVVDDETL ADTAQQLARH LATQPTFGLG LIKQAINSAE TNTLDTQLDL ERDYQRLAGR 240
  241 SADYREGVSA FLAKRSPQFT GK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	75.522879
Match:	1ey3A
Description:	Enoyl-CoA hydratase (crotonase)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
enoyl-CoA hydratase activity	3.92947460544831	bayes_pls_golite062009
CoA carboxylase activity	3.59076614105466	bayes_pls_golite062009
ligase activity, forming carbon-carbon bonds	3.4980371783229	bayes_pls_golite062009
acetyl-CoA carboxylase activity	3.34692152434862	bayes_pls_golite062009
3-hydroxyacyl-CoA dehydrogenase activity	2.44182589784656	bayes_pls_golite062009
dodecenoyl-CoA delta-isomerase activity	1.80820904754223	bayes_pls_golite062009
catalytic activity	1.46154163027498	bayes_pls_golite062009
propionyl-CoA carboxylase activity	1.20853698666984	bayes_pls_golite062009
long-chain-3-hydroxyacyl-CoA dehydrogenase activity	1.03484393216342	bayes_pls_golite062009
ligase activity	0.98581896521131	bayes_pls_golite062009
RNA binding	0.599974851773164	bayes_pls_golite062009
binding	0.578223105269736	bayes_pls_golite062009
long-chain-enoyl-CoA hydratase activity	0.571617594666499	bayes_pls_golite062009
nucleic acid binding	0.472835473017362	bayes_pls_golite062009
3-hydroxybutyryl-CoA epimerase activity	0.241955774397835	bayes_pls_golite062009
hydrolase activity	0.167287221009063	bayes_pls_golite062009
racemase and epimerase activity, acting on hydroxy acids and derivatives	0.099208209617217	bayes_pls_golite062009
intramolecular oxidoreductase activity, transposing C=C bonds	0.0918189681606029	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: