YRC Public Data Repository - Protein Structure Prediction

Protein:	PP2AA_BOVIN
Organism:	Bos taurus
Length:	309 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PP2AA_BOVIN.

Description	E-value	Query Range	Subject Range
gi\|48146951 - gi\|48146951\|emb\|CAG33698.1\| PPP2CA [Homo sapiens]	0.0	[1..309]	[1..309]
gi\|61554531 - gi\|61554531\|gb\|AAX46574.1\| protein phosphatase 2, catalytic subunit, alpha isoform [Bos taurus]	0.0	[1..309]	[1..309]
gi\|30584001, gi\|... - gi\|60652621\|gb\|AAX29005.1\| protein phosphatase 2 catalytic subunit alpha isoform [synthetic construc...	0.0	[1..309]	[1..309]
gi\|194765657, gi... - gi\|194765657\|ref\|XP_001964943.1\| GF21831 [Drosophila ananassae], gi\|190617553\|gb\|EDV33077.1\| GF21831... gi\|190662070, gi... - gi\|194862952\|ref\|XP_001970203.1\| GG10501 [Drosophila erecta], gi\|190662070\|gb\|EDV59262.1\| GG10501 [D... gi\|194106967, gi... - gi\|195148104\|ref\|XP_002015014.1\| GL18646 [Drosophila persimilis], gi\|194106967\|gb\|EDW29010.1\| GL1864... gi\|227335 - gi\|227335\|prf\|\|1702219A protein phosphatase 2A gi\|220955558, gi... - gi\|220955558\|gb\|ACL90322.1\| mts-PA [synthetic construct], gi\|220945882\|gb\|ACL85484.1\| mts-PA [synthe... mts-PA, FBpp0310... - The gene microtubule star is referred to in FlyBase by the symbol Dmel\mts (CG7109, FBgn0004177). It... gi\|194129999, gi... - gi\|195339019\|ref\|XP_002036119.1\| GM16609 [Drosophila sechellia], gi\|194129999\|gb\|EDW52042.1\| GM16609... gi\|194174098, gi... - gi\|195471409\|ref\|XP_002087997.1\| GE14639 [Drosophila yakuba], gi\|194174098\|gb\|EDW87709.1\| GE14639 [D... gi\|195577391, gi... - gi\|195577391\|ref\|XP_002078554.1\| GD23492 [Drosophila simulans], gi\|194190563\|gb\|EDX04139.1\| GD23492 ... gi\|198474511, gi... - gi\|198474511\|ref\|XP_002132708.1\| GA25737 [Drosophila pseudoobscura pseudoobscura], gi\|198138424\|gb\|E...	0.0	[1..309]	[1..309]
gi\|119390121 - gi\|119390121\|pdb\|2IE3\|C Chain C, Structure Of The Protein Phosphatase 2a Core Enzyme Bound To Tumor-... PP2AA_RAT - Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform OS=Rattus norvegicus GN=Ppp2... PP2AA_MOUSE - Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform OS=Mus musculus GN=Ppp2ca PE... gi\|56819 - gi\|56819\|emb\|CAA34166.1\| unnamed protein product [Rattus rattus]	0.0	[1..309]	[1..309]
gi\|55742595 - ref\|NP_998458.1\| protein phosphatase 2A, catalytic subunit, beta isoform [Danio rerio] gi\|41351209, gi\|... - gi\|55742595\|ref\|NP_998458.1\| protein phosphatase 2A, catalytic subunit, beta isoform [Danio rerio], ...	0.0	[1..309]	[1..309]
gi\|50978726, gi\|... - gi\|50978726\|ref\|NP_001003063.1\| type 2A protein phosphatase catalytic subunit [Canis lupus familiari...	0.0	[1..309]	[1..309]
PP2AB_RABIT - Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform OS=Oryctolagus cuniculus GN=P...	0.0	[1..309]	[1..309]

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Predicted Domain #1

Region A:
Residues: [1-309]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDEKVFTKEL DQWIEQLNEC KQLSESQVKS LCEKAKEILT KESNVQEVRC PVTVCGDVHG  60
   61 QFHDLMELFR IGGKSPDTNY LFMGDYVDRG YYSVETVTLL VALKVRYRER ITILRGNHES 120
  121 RQITQVYGFY DECLRKYGNA NVWKYFTDLF DYLPLTALVD GQIFCLHGGL SPSIDTLDHI 180
  181 RALDRLQEVP HEGPMCDLLW SDPDDRGGWG ISPRGAGYTF GQDISETFNH ANGLTLVSRA 240
  241 HQLVMEGYNW CHDRNVVTIF SAPNYCYRCG NQAAIMELDD TLKYSFLQFD PAPRRGEPHV 300
  301 TRRTPDYFL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	111.0
Match:	2ie4C
Description:	No description for 2ie4C was found.

Predicted functions:

Term	Confidence	Notes
phosphoprotein phosphatase activity	11.6417995308386	bayes_pls_golite062009
protein serine/threonine phosphatase activity	10.6440947462013	bayes_pls_golite062009
phosphatase activity	10.5525832502704	bayes_pls_golite062009
phosphoric ester hydrolase activity	10.3702645338723	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	9.02791306892273	bayes_pls_golite062009
calcium-dependent protein serine/threonine phosphatase activity	6.04386346716682	bayes_pls_golite062009
myosin phosphatase activity	5.31703100176823	bayes_pls_golite062009
hydrolase activity	3.13006743434485	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.68552051869632	bayes_pls_golite062009
kinase activity	1.67788383575784	bayes_pls_golite062009
structural molecule activity	1.5850868178597	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.57807175808088	bayes_pls_golite062009
protein kinase activity	1.4514460578232	bayes_pls_golite062009
binding	1.44538582463569	bayes_pls_golite062009
catalytic activity	1.39852585255405	bayes_pls_golite062009
transferase activity	1.3407391509244	bayes_pls_golite062009
protein binding	1.33435965029646	bayes_pls_golite062009
transporter activity	1.24767072239634	bayes_pls_golite062009
molecular transducer activity	1.08090214431427	bayes_pls_golite062009
signal transducer activity	1.08090214431427	bayes_pls_golite062009
calmodulin binding	0.77173071932406	bayes_pls_golite062009
protein serine/threonine kinase activity	0.66803085638835	bayes_pls_golite062009
substrate-specific transporter activity	0.528189469950839	bayes_pls_golite062009
structural constituent of muscle	0.126411744957937	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: