YRC Public Data Repository - Protein Structure Prediction

Protein:	NADB_ECOLI
Organism:	Escherichia coli
Length:	540 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NADB_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|108780351, gi... - gi\|108808438\|ref\|YP_652354.1\| L-aspartate oxidase [Yersinia pestis Antiqua], gi\|108780351\|gb\|ABG1440... gi\|108775009, gi... - gi\|108811361\|ref\|YP_647128.1\| L-aspartate oxidase [Yersinia pestis Nepal516], gi\|108775009\|gb\|ABG175... Q667U3\|Q667U3_YERPS - L-aspartate oxidase - Yersinia pseudotuberculosis gi\|169749961, gi... - gi\|170023427\|ref\|YP_001719932.1\| L-aspartate oxidase [Yersinia pseudotuberculosis YPIII], gi\|1697499... gi\|186896311, gi... - gi\|186896311\|ref\|YP_001873423.1\| L-aspartate oxidase [Yersinia pseudotuberculosis PB1/+], gi\|1866993... gi\|21958053, gi\|... - gi\|22125189\|ref\|NP_668612.1\| L-aspartate oxidase [Yersinia pestis KIM], gi\|21958053\|gb\|AAM84863.1\|AE... gi\|25284611 - gi\|25284611\|pir\|\|AF0330 L-aspartate oxidase (EC 1.4.3.16) [imported] - Yersinia pestis (strain CO92) gi\|51590496, gi\|... - gi\|51597214\|ref\|YP_071405.1\| L-aspartate oxidase [Yersinia pseudotuberculosis IP 32953], gi\|51590496... gi\|45442296, gi\|... - gi\|45442296\|ref\|NP_993835.1\| L-aspartate oxidase [Yersinia pestis biovar Microtus str. 91001], gi\|45... gi\|149365398, gi... - gi\|149365398\|ref\|ZP_01887433.1\| L-aspartate oxidase [Yersinia pestis CA88-4125], gi\|149291811\|gb\|EDM... gi\|145598845, gi... - gi\|145598845\|ref\|YP_001162921.1\| L-aspartate oxidase [Yersinia pestis Pestoides F], gi\|145210541\|gb\|... gi\|16122914, gi\|... - gi\|218929782\|ref\|YP_002347657.1\| L-aspartate oxidase [Yersinia pestis CO92], gi\|16122914\|ref\|NP_4062... gi\|167470539 - gi\|167470539\|ref\|ZP_02335243.1\| L-aspartate oxidase [Yersinia pestis FV-1]	506.0	[0..1]	[533..13]
gi\|165925217, gi... - gi\|165925217\|ref\|ZP_02221049.1\| L-aspartate oxidase [Yersinia pestis biovar Orientalis str. F1991016... gi\|165937100, gi... - gi\|89104165\|ref\|ZP_01176716.1\| COG0029: Aspartate oxidase [Yersinia pestis biovar Orientalis str. IP... gi\|165992446, gi... - gi\|166008064\|ref\|ZP_02228962.1\| L-aspartate oxidase [Yersinia pestis biovar Antiqua str. E1979001], ... gi\|166206503, gi... - gi\|166212572\|ref\|ZP_02238607.1\| L-aspartate oxidase [Yersinia pestis biovar Antiqua str. B42003004],... gi\|167050850, gi... - gi\|167398346\|ref\|ZP_02303870.1\| L-aspartate oxidase [Yersinia pestis biovar Antiqua str. UG05-0454],... gi\|167421279, gi... - gi\|167421279\|ref\|ZP_02313032.1\| L-aspartate oxidase [Yersinia pestis biovar Orientalis str. MG05-102... gi\|162419916, gi... - gi\|77634982\|ref\|ZP_00797072.1\| COG0029: Aspartate oxidase [Yersinia pestis Angola], gi\|162419916\|ref... gi\|153947342, gi... - gi\|77629933\|ref\|ZP_00792519.1\| COG0029: Aspartate oxidase [Yersinia pseudotuberculosis IP 31758], gi... NADB_YERPE - L-aspartate oxidase OS=Yersinia pestis GN=nadB PE=3 SV=2 gi\|229681540, gi... - gi\|229901611\|ref\|ZP_04516733.1\| quinolinate synthase, L-aspartate oxidase (B protein) subunit [Yersi... gi\|167423350, gi... - gi\|167423350\|ref\|ZP_02315103.1\| L-aspartate oxidase [Yersinia pestis biovar Mediaevalis str. K197300... gi\|229688385, gi... - gi\|229898837\|ref\|ZP_04513982.1\| quinolinate synthase, L-aspartate oxidase (B protein) subunit [Yersi... gi\|229701337, gi... - gi\|229895531\|ref\|ZP_04510702.1\| quinolinate synthase, L-aspartate oxidase (B protein) subunit [Yersi... gi\|229694639, gi... - gi\|229838273\|ref\|ZP_04458432.1\| quinolinate synthase, L-aspartate oxidase (B protein) subunit [Yersi...	505.0	[0..1]	[533..1]
gi\|88819828, gi\|... - gi\|88858211\|ref\|ZP_01132853.1\| L-aspartate oxidase [Pseudoalteromonas tunicata D2], gi\|88819828\|gb\|E...	504.0	[0..1]	[537..1]
gi\|50122207, gi\|... - gi\|50122207\|ref\|YP_051374.1\| L-aspartate oxidase [Pectobacterium atrosepticum SCRI1043], gi\|49612733...	503.0	[0..1]	[533..1]
gi\|238784179, gi... - gi\|77958597\|ref\|ZP_00822628.1\| COG0029: Aspartate oxidase [Yersinia bercovieri ATCC 43970], gi\|23878...	503.0	[0..1]	[533..1]
gi\|56178935, gi\|... - gi\|56459925\|ref\|YP_155206.1\| L-aspartate oxidase [Idiomarina loihiensis L2TR], gi\|56178935\|gb\|AAV816...	503.0	[0..1]	[534..1]
gi\|238723818, gi... - gi\|77974730\|ref\|ZP_00830269.1\| COG0029: Aspartate oxidase [Yersinia frederiksenii ATCC 33641], gi\|23...	502.0	[0..1]	[533..1]
gi\|238793779, gi... - gi\|77978416\|ref\|ZP_00833845.1\| COG0029: Aspartate oxidase [Yersinia intermedia ATCC 29909], gi\|23879...	501.0	[0..1]	[533..1]
gi\|37527223, gi\|... - gi\|37527223\|ref\|NP_930567.1\| L-aspartate oxidase [Photorhabdus luminescens subsp. laumondii TTO1], g...	500.0	[0..1]	[533..1]
gi\|987649, gi\|28... - gi\|987649\|dbj\|BAA10921.1\| L-aspartate oxidase [Escherichia coli K-12], gi\|5542180\|pdb\|1CHU\|A Chain A... gi\|987649\|dbj\|BA... - L-aspartate oxidase [Escherichia coli]	499.0	[0..1]	[540..1]

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Predicted Domain #1

Region A:
Residues: [1-540]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNTLPEHSCD VLIIGSGAAG LSLALRLADQ HQVIVLSKGP VTEGSTFYAQ GGIAAVFDET  60
   61 DSIDSHVEDT LIAGAGICDR HAVEFVASNA RSCVQWLIDQ GVLFDTHIQP NGEESYHLTR 120
  121 EGGHSHRRIL HAADATGREV ETTLVSKALN HPNIRVLERS NAVDLIVSDK IGLPGTRRVV 180
  181 GAWVWNRNKE TVETCHAKAV VLATGGASKV YQYTTNPDIS SGDGIAMAWR AGCRVANLEF 240
  241 NQFHPTALYH PQARNFLLTE ALRGEGAYLK RPDGTRFMPD FDERGELAPR DIVARAIDHE 300
  301 MKRLGADCMF LDISHKPADF IRQHFPMIYE KLLGLGIDLT QEPVPIVPAA HYTCGGVMVD 360
  361 DHGRTDVEGL YAIGEVSYTG LHGANRMASN SLLECLVYGW SAAEDITRRM PYAHDISTLP 420
  421 PWDESRVENP DERVVIQHNW HELRLFMWDY VGIVRTTKRL ERALRRITML QQEIDEYYAH 480
  481 FRVSNNLLEL RNLVQVAELI VRCAMMRKES RGLHFTLDYP ELLTHSGPSI LSPGNHYINR 540
  541

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	142.0
Match:	1chuA
Description:	L-aspartate oxidase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
succinate dehydrogenase activity	10.1355816274563	bayes_pls_golite062009
L-aspartate oxidase activity	7.97437641217089	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors	7.4746833070215	bayes_pls_golite062009
aspartate oxidase activity	7.32727957948448	bayes_pls_golite062009
succinate dehydrogenase (ubiquinone) activity	7.26739070786089	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor	7.26739070786089	bayes_pls_golite062009
oxidoreductase activity	6.1068533307878	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH	5.74880353813045	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	5.00880700655468	bayes_pls_golite062009
electron carrier activity	2.8553929424231	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor	2.26549080531565	bayes_pls_golite062009
oxygen-dependent protoporphyrinogen oxidase activity	2.16428165652808	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	2.11247286526577	bayes_pls_golite062009
dihydrolipoyl dehydrogenase activity	1.91979117253135	bayes_pls_golite062009
catalytic activity	1.75556359035561	bayes_pls_golite062009
binding	1.41440014472974	bayes_pls_golite062009
transporter activity	0.890824576391732	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors	0.798505263716232	bayes_pls_golite062009
transmembrane transporter activity	0.706117386114413	bayes_pls_golite062009
fumarate reductase (NADH) activity	0.65260793370113	bayes_pls_golite062009
FAD binding	0.503028015880333	bayes_pls_golite062009
substrate-specific transporter activity	0.491481205015383	bayes_pls_golite062009
succinate-CoA ligase activity	0.468246082354334	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.26114823844682	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	0.224438371728402	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	0.164825358655637	bayes_pls_golite062009
protein binding	0.159209309982354	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: