YRC Public Data Repository - Protein Structure Prediction

Protein:	MEND_ECOLI
Organism:	Escherichia coli
Length:	556 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MEND_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|7436698 - pir\|\|C70341 acetolactate synthase (EC 4.1.3.18) large chain - Aquifex aeolicus gi\|15605942, gi\|... - gi\|2983101\|gb\|AAC06706.1\| acetolactate synthase large subunit [Aquifex aeolicus VF5], gi\|15605942\|re...	592.0	[0..6]	[556..2]
gi\|219993234, gi... - gi\|89210057\|ref\|ZP_01188450.1\| Acetolactate synthase, large subunit, biosynthetic type [Halothermoth...	591.0	[0..7]	[556..3]
gi\|91202797 - gi\|91202797\|emb\|CAJ72436.1\| strongly similar to acetohydroxy acid synthase IilvB [Candidatus Kueneni...	590.0	[0..3]	[556..6]
gi\|88602528, gi\|... - gi\|88602528\|ref\|YP_502706.1\| acetolactate synthase, large subunit, biosynthetic type [Methanospirill...	584.0	[0..8]	[556..2]
gi\|146399240, gi... - gi\|88936939\|ref\|ZP_01142531.1\| Acetolactate synthase, large subunit, biosynthetic type [Geobacter ur...	584.0	[0..6]	[556..1]
gi\|222054607, gi... - gi\|222054607\|ref\|YP_002536969.1\| acetolactate synthase, large subunit, biosynthetic type [Geobacter ...	583.0	[0..6]	[556..1]
gi\|68249831, gi\|... - gi\|68249831\|ref\|YP_248943.1\| acetolactate synthase 3 catalytic subunit [Haemophilus influenzae 86-02... gi\|144986629, gi... - gi\|145632973\|ref\|ZP_01788706.1\| acetolactate synthase III large subunit [Haemophilus influenzae 3655... gi\|53732850 - gi\|53732850\|ref\|ZP_00349598.1\| COG0028: Thiamine pyrophosphate-requiring enzymes [acetolactate synth... gi\|229845604, gi... - gi\|229845604\|ref\|ZP_04465730.1\| acetolactate synthase 3 catalytic subunit [Haemophilus influenzae 6P...	580.0	[0..7]	[556..3]
ILVI_HAEIN - Acetolactate synthase large subunit OS=Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 ... ILVI_HAEIN - Acetolactate synthase large subunit OS=Haemophilus influenzae GN=ilvI PE=3 SV=1 gi\|145273548, gi... - gi\|145641734\|ref\|ZP_01797310.1\| acetolactate synthase III large subunit [Haemophilus influenzae R302... gi\|145641734 - gi\|145641734\|ref\|ZP_01797310.1\| acetolactate synthase III large subunit [Haemophilus influenzae R302...	579.0	[0..7]	[556..3]
gi\|42631583 - gi\|42631583\|ref\|ZP_00157121.1\| COG0028: Thiamine pyrophosphate-requiring enzymes [acetolactate synth...	579.0	[0..7]	[556..3]
gi\|21226772, gi\|... - gi\|21226772\|ref\|NP_632694.1\| acetolactate synthase 3 catalytic subunit [Methanosarcina mazei Go1], g...	579.0	[0..1]	[556..1]

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Predicted Domain #1

Region A:
Residues: [1-556]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVSAFNRRW AAVILEALTR HGVRHICIAP GSRSTPLTLA AAENSAFIHH THFDERGLGH  60
   61 LALGLAKVSK QPVAVIVTSG TAVANLYPAL IEAGLTGEKL ILLTADRPPE LIDCGANQAI 120
  121 RQPGMFASHP THSISLPRPT QDIPARWLVS TIDHALGTLH AGGVHINCPF AEPLYGEMDD 180
  181 TGLSWQQRLG DWWQDDKPWL REAPRLESEK QRDWFFWRQK RGVVVAGRMS AEEGKKVALW 240
  241 AQTLGWPLIG DVLSQTGQPL PCADLWLGNA KATSELQQAQ IVVQLGSSLT GKRLLQWQAS 300
  301 CEPEEYWIVD DIEGRLDPAH HRGRRLIANI ADWLELHPAE KRQPWCVEIP RLAEQAMQAV 360
  361 IARRDAFGEA QLAHRICDYL PEQGQLFVGN SLVVRLIDAL SQLPAGYPVY SNRGASGIDG 420
  421 LLSTAAGVQR ASGKPTLAIV GDLSALYDLN ALALLRQVSA PLVLIVVNNN GGQIFSLLPT 480
  481 PQSERERFYL MPQNVHFEHA AAMFELKYHR PQNWQELETA FADAWRTPTT TVIEMVVNDT 540
  541 DGAQTLQQLL AQVSHL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	154.0
Match:	1ybhA
Description:	Crystal structure of Arabidopsis thaliana Acetohydroxyacid synthase In Complex With A Sulfonylurea Herbicide Chlorimuron Ethyl
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	2.62581591393304	bayes_pls_golite062009
transferase activity, transferring aldehyde or ketonic groups	2.19966670927343	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	2.14637563702643	bayes_pls_golite062009
pyruvate dehydrogenase activity	2.12899981523286	bayes_pls_golite062009
pyruvate dehydrogenase (acetyl-transferring) activity	1.99251210772227	bayes_pls_golite062009
transketolase activity	1.65415226350177	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: