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View Structure Prediction Details

Protein: IL5_SHEEP
Organism: Ovis aries
Length: 132 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for IL5_SHEEP.

Description E-value Query
Range		 Subject
Range
IL5_HORSE - Interleukin-5 OS=Equus caballus GN=IL5 PE=2 SV=1
 244.0 [0..1] [131..3]
gi|197216041, gi... - gi|197216041|gb|ACH53244.1| interleukin 5 [Bos gaurus], gi|197216039|gb|ACH53243.1| interleukin 5 [B...
gi|197215997, gi... - gi|197215997|gb|ACH53222.1| interleukin 5 [Ovis aries], gi|197215995|gb|ACH53221.1| interleukin 5 [O...
gi|197215971, gi... - gi|197215973|gb|ACH53210.1| interleukin 5 [Capra hircus], gi|197215971|gb|ACH53209.1| interleukin 5 ...
gi|197216085, gi... - gi|197216133|gb|ACH53290.1| interleukin 5 [Bos indicus], gi|197216131|gb|ACH53289.1| interleukin 5 [...
IL5_BOVIN - Interleukin-5 OS=Bos taurus GN=IL5 PE=2 SV=1
gi|197216063, gi... - gi|197216065|gb|ACH53256.1| interleukin 5 [Bison bison], gi|197216063|gb|ACH53255.1| interleukin 5 [...
 242.0 [0..1] [132..3]
IL5_FELCA - Interleukin-5 OS=Felis catus GN=IL5 PE=2 SV=1
 228.0 [0..14] [132..16]
IL5_MERUN - Interleukin-5 OS=Meriones unguiculatus GN=IL5 PE=2 SV=1
 228.0 [0..1] [131..1]
IL5_PIG - Interleukin-5 OS=Sus scrofa GN=IL5 PE=2 SV=1
 225.0 [0..12] [132..14]
IL5_RAT - Interleukin-5 OS=Rattus norvegicus GN=Il5 PE=3 SV=1
gi|313255 - gi|313255|emb|CAA38283.1| interleukin 5 [Rattus rattus]
 225.0 [0..1] [131..1]
IL5_MOUSE - Interleukin-5 OS=Mus musculus GN=Il5 PE=1 SV=1
 224.0 [0..2] [131..3]
IL5_SIGHI - Interleukin-5 OS=Sigmodon hispidus GN=IL5 PE=2 SV=1
 224.0 [0..1] [131..1]

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Predicted Domain #1
Region A:
Residues: [1-132] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHLRLTLVAL GAAYVCANAV ESTMNRLVAE TLTLLSTHQT LLIGDGNLMI PTPQHTNHQL  60
   61 CIEEVFQGID TLKNQTAQGD AVKKIFRNLS LIKEYIDLQK RKCGGERWRV KQFLDYLQVF 120
  121 LGVINTEWTM ES

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 51.045757
Match: 1hulA
Description: Interleukin-5
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cytokine receptor binding 6.47223189691244 bayes_pls_golite062009
receptor binding 5.3304255990112 bayes_pls_golite062009
cytokine activity 5.1883241815362 bayes_pls_golite062009
growth factor activity 4.92105782010612 bayes_pls_golite062009
protein binding 3.52041127390038 bayes_pls_golite062009
binding 2.74412602806415 bayes_pls_golite062009
prolactin receptor binding 2.45721634350294 bayes_pls_golite062009
interleukin-6 receptor binding 2.37535614986843 bayes_pls_golite062009
hormone activity 2.25587306265428 bayes_pls_golite062009
interleukin-10 receptor binding 2.21581243177298 bayes_pls_golite062009
interleukin-12 binding 1.970502825442 bayes_pls_golite062009
growth hormone activity 1.68812520178671 bayes_pls_golite062009
interleukin-27 binding 1.65090888783496 bayes_pls_golite062009
ciliary neurotrophic factor receptor binding 1.59946630359187 bayes_pls_golite062009
interleukin-2 receptor binding 1.04202431319586 bayes_pls_golite062009
transcription regulator activity 0.997277159889548 bayes_pls_golite062009
interleukin-12 beta subunit binding 0.905609556134391 bayes_pls_golite062009
macrophage colony stimulating factor receptor binding 0.677853475084802 bayes_pls_golite062009
erythropoietin receptor binding 0.5867301437183 bayes_pls_golite062009
granulocyte colony-stimulating factor receptor binding 0.325361365455201 bayes_pls_golite062009
catalytic activity 0.246169290135575 bayes_pls_golite062009
interleukin-12 receptor binding 0.218984052557791 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle