YRC Public Data Repository - Protein Structure Prediction

Protein:	IADA_ECOLI
Organism:	Escherichia coli
Length:	390 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for IADA_ECOLI.

Description	E-value	Query Range	Subject Range
URE1_BACC1 - Urease subunit alpha OS=Bacillus cereus (strain ATCC 10987 / NRS 248) GN=ureC PE=3 SV=1	225.0	[0..9]	[376..70]
gi\|19310948 - gi\|19310948\|gb\|AAL86691.1\| urea amidohydrolase alpha subunit [Nitrosococcus oceani] gi\|19310948 - gi\|19310948\|gb\|AAL86691.1\|AF417006_3 urea amidohydrolase alpha subunit [Nitrosococcus oceani]	222.0	[0..3]	[389..60]
gi\|62182937, gi\|... - gi\|62182937\|ref\|YP_219354.1\| isoaspartyl dipeptidase [Salmonella enterica subsp. enterica serovar Ch...	221.0	[0..1]	[390..1]
gi\|16423078, gi\|... - gi\|16767756\|ref\|NP_463371.1\| isoaspartyl dipeptidase [Salmonella typhimurium LT2], gi\|16423078\|gb\|AA... gi\|197242064, gi... - gi\|197263809\|ref\|ZP_03163883.1\| beta-aspartyl peptidase [Salmonella enterica subsp. enterica serovar... lcl\|NC_016856.1_... - [gene=iadA] [protein=isoaspartyl dipeptidase] [protein_id=YP_005240846.1] [location=complement(47789... gi\|205330377, gi... - gi\|205330377\|gb\|EDZ17141.1\| beta-aspartyl peptidase [Salmonella enterica subsp. enterica serovar 4,[...	220.0	[0..1]	[390..1]
URE1_CLOTH - Urease subunit alpha OS=Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB...	219.0	[0..2]	[388..63]
gi\|10336584 - gi\|10336584\|dbj\|BAB13788.1\| urease alpha subunit UreC [Vibrio parahaemolyticus]	219.0	[0..3]	[388..61]
gi\|214000641 - gi\|214000641\|ref\|ZP_03411376.1\| isoaspartyl dipeptidase [Salmonella enterica subsp. enterica serovar... gi\|213864774 - gi\|213864774\|ref\|ZP_03386893.1\| isoaspartyl dipeptidase [Salmonella enterica subsp. enterica serovar... gi\|213428377 - gi\|213428377\|ref\|ZP_03361127.1\| isoaspartyl dipeptidase [Salmonella enterica subsp. enterica serovar... gi\|213052217 - gi\|213052217\|ref\|ZP_03345095.1\| isoaspartyl dipeptidase [Salmonella enterica subsp. enterica serovar... gi\|197365220, gi... - gi\|197365220\|ref\|YP_002144857.1\| isoaspartyl dipeptidase [Salmonella enterica subsp. enterica serova... gi\|56130553, gi\|... - gi\|56416296\|ref\|YP_153371.1\| isoaspartyl dipeptidase [Salmonella enterica subsp. enterica serovar Pa...	219.0	[0..1]	[390..1]
gi\|16505629, gi\|... - gi\|25290194\|pir\|\|AF1067 probable isoaspartyl dipeptidase (EC 3.4.19.-) [imported] - Salmonella enter... gi\|16763320 - gi\|16763320\|ref\|NP_458937.1\| isoaspartyl dipeptidase [Salmonella enterica subsp. enterica serovar Ty... gi\|29140437, gi\|... - gi\|29144798\|ref\|NP_808140.1\| isoaspartyl dipeptidase [Salmonella enterica subsp. enterica serovar Ty...	218.0	[0..1]	[390..1]
gi\|7839375 - gi\|7839375\|gb\|AAF70248.1\| UreC [Prochlorococcus marinus] URE1_PROMP - Urease subunit alpha OS=Prochlorococcus marinus subsp. pastoris (strain CCMP1986 / MED4) GN=ureC PE=... URE1_PROS9 - Urease subunit alpha OS=Prochlorococcus marinus subsp. pastoris (strain PCC 9511) GN=ureC PE=1 SV=1	218.0	[0..1]	[387..61]

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Predicted Domain #1

Region A:
Residues: [1-390]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIDYTAAGFT LLQGAHLYAP EDRGICDVLV ANGKIIAVAS NIPSDIVPNC TVVDLSGQIL  60
   61 CPGFIDQHVH LIGGGGEAGP TTRTPEVALS RLTEAGVTSV VGLLGTDSIS RHPESLLAKT 120
  121 RALNEEGISA WMLTGAYHVP SRTITGSVEK DVAIIDRVIG VKCAISDHRS AAPDVYHLAN 180
  181 MAAESRVGGL LGGKPGVTVF HMGDSKKALQ PIYDLLENCD VPISKLLPTH VNRNVPLFEQ 240
  241 ALEFARKGGT IDITSSIDEP VAPAEGIARA VQAGIPLARV TLSSDGNGSQ PFFDDEGNLT 300
  301 HIGVAGFETL LETVQVLVKD YDFSISDALR PLTSSVAGFL NLTGKGEILP GNDADLLVMT 360
  361 PELRIEQVYA RGKLMVKDGK ACVKGTFETA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	55.522879
Match:	1onwA
Description:	Isoaspartyl dipeptidase; Isoaspartyl dipeptidase, catalytic domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
hydrolase activity	3.06979421893431	bayes_pls_golite062009
catalytic activity	1.70199291046899	bayes_pls_golite062009
peptidase activity	0.483675247391628	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	0.0644988334012029	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: