YRC Public Data Repository - Protein Structure Prediction

Protein:	HIS4_SYNY3
Organism:	Synechocystis sp. PCC 6803
Length:	256 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HIS4_SYNY3.

Description	E-value	Query Range	Subject Range
gi\|45528492, gi\|... - gi\|67920558\|ref\|ZP_00514078.1\| Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomera...	199.0	[0..1]	[250..1]
HIS4_PROMM - 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase O...	196.0	[0..1]	[249..1]
HIS4_PROMP - 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase O...	194.0	[0..1]	[248..1]
HIS4_PROM4 - 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase O...	192.0	[0..1]	[248..1]
HIS4_PROM9 - 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase O...	190.0	[0..1]	[246..1]
HIS4_NOSS1 - 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase O... gi\|25292642 - pir\|\|AB2369 phosphorybosilformimino-5-amino-phosphorybosil-4 -imidazolecarboxamideisomerase [importe...	190.0	[0..1]	[249..1]
HIS6_AZOBR - Imidazole glycerol phosphate synthase subunit HisF OS=Azospirillum brasilense GN=hisF PE=3 SV=1	190.0	[0..1]	[250..4]
HIS4_ANAVT - 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase O...	190.0	[0..1]	[249..1]
HIS4_TRIEI - 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase O...	190.0	[0..1]	[249..1]
HIS6_GEOSL - Imidazole glycerol phosphate synthase subunit HisF OS=Geobacter sulfurreducens (strain ATCC 51573 / ... HIS6_GEOSL - Imidazole glycerol phosphate synthase subunit HisF OS=Geobacter sulfurreducens GN=hisF PE=3 SV=1	189.0	[0..2]	[245..5]

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Predicted Domain #1

Region A:
Residues: [1-256]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKILPAIDLL GGKCVRLYQG DYDQSQVYHE DPVEVARQWQ AQGASRLHLV DLDGAKEGQP  60
   61 VNLTAIANIV EALTIPVQVG GGLRDRNRVK QLLDLGVGRV ILGTIAVENP DLVGELCAEF 120
  121 PGQIVVGIDA RNGKVATRGW LETSTVEAGE LAQRMEKLGA AAIIYTDIHR DGTMQGPNLD 180
  181 ALRQLASQLT IPVIASGGVS QVEDLLNLLS LESLGVNGVI IGKALYTGDI QLAEAIRAVG 240
  241 NGRWQDVPPL DFPRLG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	37.522879
Match:	1vzwA
Description:	Crystal structure of the bifunctional protein Pria
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
imidazoleglycerol-phosphate synthase activity	2.95067072425787	bayes_pls_golite062009
catalytic activity	2.81275055404078	bayes_pls_golite062009
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity	2.33042272190684	bayes_pls_golite062009
transferase activity, transferring pentosyl groups	1.62677246976022	bayes_pls_golite062009
lyase activity	0.9228652996943	bayes_pls_golite062009
indole-3-glycerol-phosphate synthase activity	0.68686049013171	bayes_pls_golite062009
tryptophan synthase activity	0.58404422121628	bayes_pls_golite062009
carboxy-lyase activity	0.33204235112025	bayes_pls_golite062009
carbon-carbon lyase activity	0.1981583216852	bayes_pls_golite062009
isomerase activity	0.14149405165663	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: